Commercial or Open Source Closed Loop Impact on Pregnancy Study

NCT ID: NCT06654713

Last Updated: 2025-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-03-13

Study Completion Date

2029-12-31

Brief Summary

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The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are:

* What are the maternal and neonatal outcomes with AID system use in pregnancy?
* What are the glycemic outcomes with AID system use in pregnancy?
* What are the behavioral and emotional outcomes with AID system use in pregnancy?

Researchers will compare pregnant people who use commercial AID systems and pregnant people who use open source AID systems to see if outcomes are different with these different types of systems.

Participants will be asked to remotely share their AID system data with the research team; complete online surveys regarding behavioral and emotional health; and sign an authorization to release health information to allow the research team to access medical records.

Detailed Description

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Conditions

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Type 1 Diabetes Pregnancy, High Risk Insulin Dependent Diabetes Pregnancy Related

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Commercial AID system

Pregnant individuals with type 1 diabetes (T1D) using commercially available automated insulin delivery (AID) systems for glycemic management in pregnancy

Commercial AID system

Intervention Type OTHER

AID system that is commercially available and FDA approved for use

Open source AID system

Pregnant individuals with type 1 diabetes T1D) using open source automated insulin delivery (AID) systems (also known as do-it-yourself AID systems or hacked AID systems) for glycemic management in pregnancy

Open source AID system

Intervention Type OTHER

AID system that uses unregulated open-source software to customize an insulin delivery algorithm to connect an insulin pump to a continuous glucose monitor

Interventions

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Commercial AID system

AID system that is commercially available and FDA approved for use

Intervention Type OTHER

Open source AID system

AID system that uses unregulated open-source software to customize an insulin delivery algorithm to connect an insulin pump to a continuous glucose monitor

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Pregnant
* Diagnosis of type 1 diabetes (T1D) prior to pregnancy
* Active use of automated insulin delivery (AID) system

Exclusion Criteria

* Diagnosis of other forms of diabetes (gestational diabetes, type 2 diabetes, monogenic diabetes)
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nasim Sobhani, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Locations

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University of California, San Francisco

San Francisco, California, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Primary Investigator

Role: CONTACT

(415) 307-9319

Facility Contacts

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Nasim Sobhani

Role: primary

415-307-9319

Other Identifiers

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24-42036

Identifier Type: -

Identifier Source: org_study_id

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