Participants with Mild to Moderate Hidradenitis Suppurativa Will Receive EVO101 a Topical Cream 0.1%

NCT ID: NCT06645821

Last Updated: 2024-12-11

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: EARLY_PHASE1
• Total Enrollment: 15 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-12-03
• Study Completion Date: 2025-05-31

Brief Summary

The goal of this clinical trial is to learn if drug EVO101 works to treat mild to moderate hidradenitis suppurativa in adults. The main questions it aims to answer are:

Does drug EVO101 lower the total number of lesion a participant has from the first visit to the last visit.

What medical problems do participants have when applying drug EVO101 Does a participant perceive a change in their hidradenitis suppurativa symptoms based on patient reported outcome questionnaires.

Participants will:

Apply EVO101 topical cream 0.1% topically Visit the clinic four times unless the first and second appointment have to be done separately then there will be five clinic visits and one phone call over a twelve week period.

Keep a dosing diary

Conditions

Hidradenitis Suppurativa (HS)

Keywords

EVO101; Hidradenitis Suppurativa; topical cream; Acne inversa

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Open label EVO101 topical cream 0.1%

All eligible subjects will receive open label EVO101 topical cream 0.1%

Group Type: EXPERIMENTAL

EVO101

Intervention Type: DRUG

EVO101 topical cream 0.1%

Interventions

EVO101

EVO101 topical cream 0.1%

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Ability to comprehend and willingness to sign a written informed consent form (ICF) for the study.

2. Age ≥ 18 years at the time of signing the ICF (informed consent).

3. Diagnosis of hidradenitis suppurativa (HS) for at least 3 months prior to the screening visit.

4. Mild to moderate HS (hidradenitis suppurativa) at the Baseline Visit (using the HS-PGA/Hidradenitis Suppurativa Physician's Global Assessment scale ).

5. Total hidradenitis suppurativa lesion count (abscess, fistulas, nodules, papules, and/or pustules) of at least 5 at the baseline visit.

6. Agreement to NOT use topical and/or systemic antibiotics for treatment of HS (hidradenitis suppurativa) for the duration of the study.

7. Agreement to NOT use a diluted bleach bath or topical antiseptic washes containing chlorhexidine gluconate or benzoyl peroxide. Note: Over-the-counter non-medicated soap and water is allowed.

8. For women of childbearing potential: agree to remain abstinent (refrain from heterosexual intercourse) or use a highly effective contraceptive method during the treatment period and for at least 30 days after the last application of study drug.

• A woman of childbearing potential is defined as a postmenarcheal female, who has not reached a postmenopausal state (≥ 12 continuous months of amenorrhea with no identified cause other than menopause) and has not undergone surgical sterilization (removal of ovaries and/or uterus).
• The following are highly effective contraceptive methods: combined (estrogen and progestogen containing) hormonal contraception (oral, intravaginal, transdermal) associated with inhibition of ovulation, progestogen-only hormonal contraception (oral, injectable, implantable) associated with inhibition of ovulation, intrauterine device (IUD), intrauterine hormone-releasing system (IUS), bilateral tubal occlusion, vasectomized partner, or sexual abstinence. The reliability of sexual abstinence should be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, or post-ovulation methods) and withdrawal are not acceptable methods of contraception. Females must agree not to donate ova during the study and for 30 days after the end of study visit.

9. Willing and able to comply with the study protocol and procedures.

Exclusion Criteria

1. Very severe, severe, minimal, or clear hidradenitis suppurativa Hidradenitis Suppurativa Physician's Global Assessment scale (HS-PGA).

2. Women who are pregnant (or who are considering pregnancy) or breastfeeding.

3. Subject has uncontrolled, clinically significant comorbidities that make them unsuitable for the clinical trial in the opinion of the investigator.

4. Have undergone significant trauma or major surgery (per investigator's assessment) within 30 days preceding the screening visit.

5. History of clinically significant (per investigator's judgment) drug or alcohol abuse within 6 months preceding the screening visit.

6. Use of any of the following medications or treatments within the specified time periods prior to the baseline visit:

1. < 12 weeks or 5 half-lives (whichever is longer)

• Investigational or experimental treatments.
• Immunomodulating biologic drugs

2. < 4 weeks

• Systemic JAK inhibitors.
• Systemic immunosuppressive or immunomodulating small-molecule drugs (eg, corticosteroids [oral or intravenous], avacopan, IRAK4 inhibitors, methotrexate, cyclosporine, dapsone, azathioprine).
• Surgical, laser, or any phototherapy intervention in areas with HS lesions

3. < 2 weeks

• Other systemic therapies for HS
• Retinoids, antihyperglycemics, and antiandrogens, such as acitretin, isotretinoin, metformin, spironolactone, and finasteride) with potential therapeutic impact unless the subject is on a stable dose as defined by the investigator for at least 28 days. There should be no anticipated change of these medications while the subject is on the study.

• Systemic anti-infectives for HS
• Antibiotics, antivirals, antifungals

4. <1 week

• Oral or topical PDE4 inhibitor (e.g., apremilast, crisaborole)
• Topical JAK inhibitor
• Topical anti-infectives for HS lesions

o Antibiotics, antivirals, antifungals

• Topical products containing chlorhexidine gluconate, benzoyl peroxide, or topical diluted bleach bath to treat HS. Note: Non-medicated over-the-counter soap and water are not restricted.
• Any topical drug applied onto HS lesions
• Topical or intralesional corticosteroids o Note: Use of topical corticosteroids for dermatologic diseases other than HS (Hidradenitis Suppurativa)(e.g., atopic dermatitis, psoriasis) is allowed for areas not being treated for HS (Hidradenitis Suppurativa)as long as it is not within 10cm of the areas affected by HS (Hidradenitis Suppurativa).

Inhaled corticosteroids are allowed.

7. Active participation in an experimental therapy study or who received experimental therapy within 30 days or 5 half-lives (whichever is longer) before Baseline.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Evommune, Inc.

INDUSTRY

Sponsor Role: collaborator

Virginia Clinical Research, Inc.

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Virginia Clinical Research, Inc.

Norfolk, Virginia, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

David M Pariser, MD

Role: CONTACT

Phone: 757-625-0151

Email: dpariser@pariserderm.com

Danielle L Benedict

Role: CONTACT

Phone: 757-625-0151

Email: dbenedict@vcrinc.org

Facility Contacts

Danielle Benedict

Role: primary

Erin Rivera

Role: backup

David M Pariser, MD

Role: backup

Other Identifiers

EVO101-HS001

Identifier Type: -

Identifier Source: org_study_id