Sensory Evaluation of Taste and Smell in Oncology

NCT ID: NCT06643026

Last Updated: 2024-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-22

Study Completion Date

2026-02-22

Brief Summary

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Nutritional status is a major issue in the management of cancer patients. Forty to 60% of patients are undernourished at diagnosis. This undernutrition has a direct impact on patients' health and quality of life, with a reduction in survival associated with an increase in the risk of toxicity from anti-cancer treatments (chemotherapy, radiotherapy, surgery), the risk of infection and the risk of hospitalization. Thus, it is estimated that 10-20% of cancer patients die from the consequences of their undernutrition rather than from the tumor itself (Muscaritoli et al. 2021).

It is therefore recommended to systematically implement a multimodal nutritional intervention in cancer patients (recommendations of the learned societies ESPEN, ESMO and ASCO), combining nutritional support (oral and/or enteral and/or parenteral) with physical exercise (Muscaritoli et al. 2021). However, despite the systematic provision of dietary management, the effectiveness of nutritional interventions varies from patient to patient in terms of nutritional status, quality of life and overall survival (Cintoni et al. 2023).

Among the factors impacting patient compliance with dietary measures and their efficacy, sensory alterations occurring under chemotherapy potentially have a major impact (Drareni et al., 2019).

Indeed, the vast majority of patients describe an alteration in tastes and smells after starting chemotherapy treatment. However, few studies have focused on the specific parameters associated with these alterations. The aim of this study is to prospectively assess changes in sensory perceptions and eating habits in patients undergoing chemotherapy for digestive cancer at the start of treatment and after the first cycle of chemotherapy, and to correlate these alterations with patients' nutritional profile and clinical course.

Detailed Description

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Conditions

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Digestive Cancers

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with digestive cancer traited by chemotherapy

Patients with malignant digestive tumors receiving active chemotherapy

Food preference

Intervention Type OTHER

Evaluate the impact of chemotherapy on the dietary preferences of patients with digestive cancer using a dietary and quality-of-life questionnaire at the beginning, middle and end of the chemotherapy/immunotherapy treatment.

Patients with digestive cancer traited by immunotherapy

Patients with malignant digestive tumors receiving immunotherapy only

Food preference

Intervention Type OTHER

Evaluate the impact of chemotherapy on the dietary preferences of patients with digestive cancer using a dietary and quality-of-life questionnaire at the beginning, middle and end of the chemotherapy/immunotherapy treatment.

Interventions

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Food preference

Evaluate the impact of chemotherapy on the dietary preferences of patients with digestive cancer using a dietary and quality-of-life questionnaire at the beginning, middle and end of the chemotherapy/immunotherapy treatment.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Able to complete the proposed questionnaires
* Patients over 18 years of age
* Non-opposed patients
* Digestive cancers starting chemotherapy and/or immunotherapy
* Able to eat by mouth

Exclusion Criteria

* Concomitant treatment for a non-digestive cancer (excluding basal/spinocellular carcinoma and chronic haemopathy)
* Previous ENT surgery (face/neck)
* Exclusive enteral feeding (nasogastric tube, gastrostomy) or parenteral nutrition
* Previous chemotherapy/immunotherapy \< 5 years
* Individuals deprived of liberty by a judicial or administrative decision
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital Lyon Sud

Oullins-Pierre Bénite, France, France

Site Status ACTIVE_NOT_RECRUITING

Hôpital Edouard Herriot

Lyon, , France

Site Status RECRUITING

Hôpital Croix Rousse

Lyon, , France

Site Status ACTIVE_NOT_RECRUITING

Countries

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France

Central Contacts

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Nicolas BENECH, MD, PhD

Role: CONTACT

00 33 4 26 10 94 35

Facility Contacts

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Thomas WALTER, Pr

Role: primary

0472117406

Other Identifiers

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69HCL24_0728

Identifier Type: -

Identifier Source: org_study_id