Study Results
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Basic Information
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NOT_YET_RECRUITING
350 participants
OBSERVATIONAL
2024-11-01
2025-11-01
Brief Summary
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Detailed Description
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The 2017 AHA hypertension guidelines emphasize that severe elevations in blood pressure (hypertensive crisis and hypertensive urgency) do not require emergency department visits or referrals unless there is end-organ damage . It is noted that treatment in these patients typically involves dose adjustment or a change in medication .
The 2023 ESC hypertension guidelines recommend that in patients presenting to the emergency department with a hypertensive crisis, blood pressure should be gradually lowered with oral agents over a 24-48 hour period. These patients do not usually require hospital admission but can be monitored in an outpatient setting for clinical evaluation. It is noted that their blood pressure may remain elevated upon discharge from the emergency department, and follow-up in a clinic is necessary for reevaluation of chronic therapy .
Some studies have indicated that both oral and intravenous treatments are preferred for patients presenting with hypertensive crises, highlighting that the approach can vary from physician to physician .
When evaluating literature reviews, published guidelines, and conducted studies, it is observed that there are differences between European and American approaches in defining and treating hypertensive crisis, as well as variability in physician management of these patients .
In our study, we plan to evaluate the effect of emergency department treatment on lowering blood pressure in known hypertensive patients (≥140/80) without end-organ damage. Additionally, we aim to assess the impact of the antihypertensive agents that patients routinely use on their length of stay in the emergency department, as well as the frequency and effectiveness of the medications used, and the target blood pressure values achieved post-treatment according to guidelines.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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diuretics
patients prescribed diuretics for oral treatment admitted to emergency service with elevated blood pressure
No interventions assigned to this group
Beta Blockers
patients prescribed Beta Blockers for oral treatment admitted to emergency service with elevated blood pressure
No interventions assigned to this group
Calcium Channel Blockers
patients prescribed Calcium Channel Blockers for oral treatment admitted to emergency service with elevated blood pressure
No interventions assigned to this group
ACE (angiotensin converting enzyme) Inhibitors
patients prescribed ACE (angiotensin converting enzyme) Inhibitors for oral treatment admitted to emergency service with elevated blood pressure
No interventions assigned to this group
ARB( angiotensin receptor blockers)
patients prescribed ARB( angiotensin receptor blockers) for oral treatment admitted to emergency service with elevated blood pressure
No interventions assigned to this group
combination
patients prescribed combination agents for oral treatment admitted to emergency service with elevated blood pressure
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
2. Blood pressure measured at ≥140/80.
3. Diagnosis of essential hypertension.
Exclusion Criteria
2. Individuals without a prior diagnosis of hypertension.
3. Patients with end-organ damage (hypertensive emergency).
4. Patients whose routine antihypertensive agents are unavailable.
5. Patients who leave the clinic without permission, making follow-up data inaccessible.
18 Years
ALL
No
Sponsors
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Etimesgut Military Hospital
OTHER
Saglik Bilimleri Universitesi
OTHER
Responsible Party
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Principal Investigators
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Elif HAMZACEBIOGLU KAYISOGLU, Specialist
Role: STUDY_DIRECTOR
Etimesgut Military Hospital
Gulsen AKCAY, Ass. Prof.
Role: PRINCIPAL_INVESTIGATOR
Ankara Etlik City Hospital
Locations
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Etlik City Hospital
Ankara, , Turkey (Türkiye)
Etimesgut Military Hospital
Ankara, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Elif HAMZACEBIOGLU KAYISOGLU, Specialist
Role: backup
Gulsen AKCAY, ass.prof.
Role: backup
Ilker SIRIN, Specialist
Role: backup
Fatma BUYUKCELEN CIFTCI, Resident
Role: backup
Fatma Nur KOC, Resident
Role: backup
Bedriye Muge SONMEZ, ass. prof.
Role: backup
References
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Salvetti M, Paini A, Colonetti E, Tarozzi L, Bertacchini F, Aggiusti C, Stassaldi D, Rosei CA, Rosei EA, Muiesan ML. Hypertensive emergencies and urgencies: a single-centre experience in Northern Italy 2008-2015. J Hypertens. 2020 Jan;38(1):52-58. doi: 10.1097/HJH.0000000000002213.
Nowicki J, Silka W, Zalustowicz A, Rajzer M, Olszanecka A. Uncontrolled hypertension and hypertensive urgency: One-year single-center emergency department experience. Kardiol Pol. 2024;82(4):407-415. doi: 10.33963/v.phj.100025. Epub 2024 Apr 12.
Astarita A, Covella M, Vallelonga F, Cesareo M, Totaro S, Ventre L, Apra F, Veglio F, Milan A. Hypertensive emergencies and urgencies in emergency departments: a systematic review and meta-analysis. J Hypertens. 2020 Jul;38(7):1203-1210. doi: 10.1097/HJH.0000000000002372.
Other Identifiers
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hypertension
Identifier Type: -
Identifier Source: org_study_id
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