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High-intensity Interval Training and Vitamin D Effects on Bone Metabolism Among Women Diagnosed With Osteoporosis

NCT ID: NCT06624657

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-07-15

Study Completion Date

2017-05-25

Brief Summary

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The effects of 16-week high-intensity interval training (HIIT) and vitamin D supplements on bone mineral density (BMD) in women with osteoporosis. The participants assigned for HITT exercise training with or without vitamin D supplements for 16 weeks, and the levels of serum bone parameters like, Osteocalcin (OC), Ca, and s-BAP were estimated in women with osteoporosis at baseline and after post-training interventions. In addition, the levels of Vitamin D were also identified in all women's accordingly.

Detailed Description

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our study aimed to investigate the effects of 16-week high-intensity interval training (HIIT) and vitamin D supplements on bone mineral density (BMD) in women with osteoporosis. thus, Serum levels of 25-Hydroxy-vitamin D (OH-D), Osteocalcin (OC), Ca, and s-BAP were estimated in women with osteoporosis at baseline and after post-training interventions. One-hundred twenty sedentary women aged (30-50 years) were diagnosed with osteoporosis. Patients were classified into four groups, 30 patients in each group; Control group (normal daily activities); Exercise group (HIIT-exercise for 16 weeks); Vitamin D group (vitamin D 800IU/ day for 16 weeks), and Concurrent group (HIIT exercise plus vitamin D for 16 weeks). Anthropometric measurements, BMD, serum levels of vitamin 25-(OH) D, Osteocalcin, s-BAP, and calcium were estimated in all participants' pre- and post-exercise training.

Conditions

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Osteoporosis Exercise Overtraining Vitamin D 25-Hydroxylase Deficiency

Keywords

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Exercise training, BMD, osteoporosis, Vitamin D deficiency

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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control group

Participants are women with osteoporosis Characterized by normal daily activities and diets

vitamin D supplements fo 16 weks

Intervention Type OTHER

subjects exercised by HIIT-exercise for 16 weeks

Exercise group

Participants are women's with osteoporosis participated in HIIT-exercise program interventions for 16 weeks

vitamin D supplements fo 16 weks

Intervention Type OTHER

subjects exercised by HIIT-exercise for 16 weeks

Vitamin D group

Participants are women's with osteoporosis who received vitamin D 800IU/ day for 16 weeks

vitamin D supplements fo 16 weks

Intervention Type OTHER

subjects exercised by HIIT-exercise for 16 weeks

Concurrent group

Participants are women's with osteoporosis who shared for HIIT exercise program plus vitamin D for 16 weeks

vitamin D supplements fo 16 weks

Intervention Type OTHER

subjects exercised by HIIT-exercise for 16 weeks

Interventions

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vitamin D supplements fo 16 weks

subjects exercised by HIIT-exercise for 16 weeks

Intervention Type OTHER

Other Intervention Names

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HIIT-exercise for 16 weeks

Eligibility Criteria

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Inclusion Criteria

* A healthy non-smoker premenopausal women's
* Age are 30-50 years old
* subjects who diagnosed with osteoporosis based on the clinical features of bone mineral density (BMD) measured from both lumbar spine L2 to L4, and from the right and left sides of the hip region by Dual Energy X-ray Absorptiometry (DEXA, UNIGAMMA PLUS AC 230V 50/60Hz 400w, USA) scan method.

Exclusion Criteria

* Women with; physical disability,
* abnormal hormonal levels
* severe disease complications such as chronic kidney and liver diseases,
* rheumatoid and osteoarthritis diseases
* significant overweight (BMI ≥25) and obesity (≥30 kg/m2) per recommended by the World Health Organization
* history of receiving calcium, multivitamin supplements, corticosteroids, anticonvulsants, and heparin which might affects up on the assessment of bone markers and BMD measurements were excluded from this study.
Minimum Eligible Age

30 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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King Saud University

OTHER

Sponsor Role lead

Responsible Party

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Sami Gabr

King Saud University

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Alghadir AH, Gabr SA, Iqbal A. Concurrent effects of high-intensity interval training and vitamin D supplementation on bone metabolism among women diagnosed with osteoporosis: a randomized controlled trial. BMC Musculoskelet Disord. 2025 Apr 21;26(1):381. doi: 10.1186/s12891-025-08275-x.

Reference Type DERIVED
PMID: 40259289 (View on PubMed)

Other Identifiers

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RRC-2016-028

Identifier Type: -

Identifier Source: org_study_id