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Integrative Adolescence Research Programme (IARP)

NCT ID: NCT06622681

Last Updated: 2025-12-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-21

Study Completion Date

2026-12-31

Brief Summary

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This study aims to understand child health during adolescence. We will examine the role of lifestyle (e.g. physical activity), growth trajectories and other environmental factors that can influence the development of phenotypes in adolescence which confer risk for later physical and mental disorders. With this study, we will develop a deeper understanding of adolescent health and well-being and their main determinants in the local Singaporean context, identify levers for early interventions to mitigate challenges to adolescent health and well-being and enhance protective factors for adolescents to do well in life, contribute to society and maximize their potential.

Detailed Description

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The study aims to advance current public policy and health service practices by developing public health, clinical and commercially valuable interventions within the context of expanding commercial partnerships and building multidisciplinary translational research capacity in Singapore. In addition to the early life period (i.e., the first 1,000 days), the adolescent period has been identified as a crucial second window of opportunity to influence human development and improve life-long well-being. Adolescence is a key developmental period for body, brain and socioemotional changes. Puberty is characterised by growth spurts and sexual maturation. Concurrently, the brain undergoes maturation processes that underlie higher cognitive functions. The combination of biological changes and environmental influences affect adolescent socioemotional and behaviour patterns. There is a need to raise the human potential of adolescents who will go on to become the next generation of our adult workforce, so that they lead productive, healthy, and fulfilling lives. Yet, in many developed countries, the rates of loss of subjective well-being in young people have at least doubled in the decade prior to COVID-19 and have continued to rise since 10. In the Singapore Youth Epidemiology and Resilience Study (2020-2022), 1 in 3 youths reported experiencing mental health symptoms 11. This requires the development of a cohesive response system designed to deal with the numerous factors influencing adolescent physical and mental health. Moreover, it is essential to investigate the developmental origins of metabolic diseases and neurodevelopmental disorders, which both form a major public health burden in Singapore, from as early as the adolescence phase. A transdisciplinary approach is essential to help adolescents directly recognise their diverse concerns, challenges and experiences and better understand how to manage their health and well-being. This requires going beyond traditional psychological models of mental health to examine the influences of brain and body interaction, socio-affective, behavioural and psychological development that shape adolescents' well-being. At present, there is no comprehensive multi-disciplinary (brain-body-environment) study in the general population which examine adolescent health and well-being holistically in Asia. Findings from primarily Western countries cannot be easily extrapolated to the Singaporean/Asian setting. A new holistic programme will be essential to advance the health of Asian adolescents.

Conditions

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Executive Dysfunction Physical Stress Mental Health Wellness 1

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Participant of the study

Adolescents at 13- 15 years of age, currently studying in MOE-registered secondary school in Singapore and part of the DREAMS cohort.

No intervention

Intervention Type OTHER

No intervention

Interventions

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No intervention

No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Aged 13 to 15 years of age
2. Currently studying in MOE registered school
3. Part of the DREAMS study

Exclusion Criteria

1. Not in MOE registered school
2. Not part of the DREAMS study
Minimum Eligible Age

13 Years

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Education

UNKNOWN

Sponsor Role collaborator

Nanyang Technological University

OTHER

Sponsor Role collaborator

Institute of High Performance Computing (IHPC), A*STAR Research Institutes

UNKNOWN

Sponsor Role collaborator

Institute for Human Development and Potential (IHDP), Singapore

OTHER

Sponsor Role lead

Responsible Party

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Johan Eriksson

Executive Director, Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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A*STAR Institute for Human Development and Potential (IHDP)

Singapore, Singapore, Singapore

Site Status RECRUITING

Singapore Institute of Clinical Sciences

Singapore, , Singapore

Site Status ENROLLING_BY_INVITATION

Countries

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Singapore

Central Contacts

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Janet Lim

Role: CONTACT

Phone: 88546302

Email: [email protected]

Facility Contacts

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Janet Lim, BS

Role: primary

Provided Documents

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Document Type: Informed Consent Form: IADORE SUB-STUDY BIOSAMPLE ICF_V1 dated 10Dec2024

View Document

Document Type: Informed Consent Form: IADORE SUB-STUDY BIOSAMPLE ICF

View Document

Other Identifiers

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2024-1200

Identifier Type: -

Identifier Source: org_study_id