Implementation of Surgical Safety and Intraoperative Metastasis Identification Through Deep Learning: Multicentric Video Collection for Minimally Invasive Sentinel Lymph Node Dissection in Uterine Malignancies

NCT ID: NCT06619002

Last Updated: 2024-10-02

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-09-17
• Study Completion Date: 2027-09-30

Brief Summary

The loco-regional metastatic or non-metastatic status of lymph nodes (LN) is critical for the therapeutic management of most cancer patients. Indeed, the presence or absence of lymphatic metastasis is essential for the accurate staging of the disease and strongly influence the prognosis and adjuvant treatment regimens. An important revolution in oncological surgery has been the introduction of the concept of sentinel lymph node (SLN) biopsy to reduce the complications of extensive loco-regional lymphadenectomies. SLN identification through ICG- based near-infrared fluorescence (NIR) cervical injection and its dissection is now recommended by European guidelines to stage uterine malignancies (endometrial and cervical cancers). However, SLN procedures have several limitations. In 11.2% of cases intra- or postoperative complications are reported due to anatomical structures injuries (vessels, nerves and lymphatic channels disruptions). Common mistakes, especially when the learning curve is not completed (at least 40 procedures), include mapping failure (25%) and removal of second/third-level nodes and/or empty nodes packets (8-14%). Additionally the intraoperative accuracy of frozen section is still far to be adequate with only the 65% of SLN metastasis detection.

These limitations are a result of the lack of precision of current SLN localization and analysis as well as of the overall difficulty of visualizing lymph nodes and other critical structures in the retroperitoneum.

Currently, studies on the safety of surgical procedures are based on perioperative clinical information and postoperative reports written by the surgeons themselves. Today, videos guiding minimally invasive surgical interventions allow for objective documentation of the procedure and provide opportunities to explore solutions for enhancing safety in the operating room. With an increasing use of endoscopic systems across different specialties, there is a need for standardization of training, assessment, testing and sign-off as a competent surgeon in order to improve patient safety. In laparoscopic lymph node dissection in endometrial and cervical cancer, a standardize stepwise approach to the procedure is highly recommended, by identifying key anatomic landmarks and structures, in various scenarios, that could prevent vascular, nervous and ureters injuries and enhance the mapping rate. Therefore, quantifying and studying intraoperative events such as the rate of achieving the right space dissections and anatomic structures visualization as a recommended step for safety and proficiency, would enable the examination of how best to implement guideline recommendations and seek new solutions to reduce operative risks. These videos could be utilized to train and validate artificial intelligence (AI) algorithms, with the potential to assist surgeons in the operating room and make the procedures safer. Additionally, the visual information (ICG intensity) could hide data that the AI can analyze and correlate with anatomopathological reports. By the integration of AI tool with laparoscopic/robotic platform it is possible to enhance MIS video streams in real time with surgical phases detection, events recognition, ICG signal intensity, anatomical structure identification and auto-targeting

Detailed Description

Surgery accounts for approximately two-thirds of all hospital complications. About 75% of these complications occur during surgical interventions, and half of them are considered preventable. Traditionally, studies on surgical safety have relied mainly on perioperative information and written reports from the surgical operators themselves. Nowadays, videos that guide the surgeon during minimally invasive procedures can be easily recorded, providing objective documentation of surgical interventions. Studying surgical videos and quantifying intraoperative events offer a promising new perspective on the causes of adverse events, with the potential to develop solutions for reducing surgical risks and facilitating the implementation of international safety recommendations in surgery .

Furthermore, recent advancements in Artificial Intelligence (AI) have shown great success in image understanding, raising the possibility of developing algorithms for automatic and large-scale analysis of surgical videos. These AI algorithms could also analyze surgical videos in real-time and provide decision support in the operating room.

The assessment of lymph node status is of crucial importance in uterine malignancies (endometrial and cervical cancer). The rate of positive lymph nodes in apparently early stage cancers is far to be low (10% endometrial and cervical 15% ). Indeed, the prognosis and adjuvant treatment regimens are strongly influenced by the presence of nodal involvement. Systematic extensive lymphadenectomies are often performed for staging, diagnosis of skip metastases and to define the radiation field when adjuvant radiotherapy treatments are required. Nevertheless, pelvic and/or para- aortic lymphadenectomy can lead to significant short-term and long-term complications.

What makes the burden of surgical morbidity even more difficult to bear is that in most cases, regardless of the type of pelvic malignancy, the lymph nodes are free from metastasis. This means that the majority of patients undergo an unnecessary, risky, and burdensome procedure that has no proven impact on their survival. To solve this issue in early stage endometrial and cervical cancers, evaluation of the sentinel lymph node (SLN) has acquired a valuable role..The evaluation of the first lymph node or group of lymph nodes draining the initial lesion and therefore the first station to collect neoplastic cells in case of tumor nodal spread allows node-negative patients to be spared from the surgical comorbidities associated with systematic lymphadenectomy. However even if only SLN is removed, the rate of surgical complications is still high. Capozzi et al reported a 11.2% complications rate related to intra- operative injuries of vessels, nerves, and ureters and to post-operative evidence of lymphoceles and lymphedemas due to wrong anatomy dissection and lymphatic channels disruption. It is reported a 25% of SLN mapping failure according to patients and cancer characteristics and variability in the surgical steps. In 2021 Moloney et al and in 2023 Bizzarri et al published a Delphi consensus for SLN surgical steps in endometrial and cervical cancer to improve the clinical outcomes, decrease surgical complications and bias in multicentric prospective trials. To date a learning curve of 40 procedures is demonstrated to be needed for successful bilateral mapping. Furthermore, in some case it is reported the inadvertent failure to harvest nodal tissue in 14% of cases (higher rate in obese patients with endometrial cancer) with empty packets that may lead to overtreatment for patient safety. Sentinel node frozen section analysis tough then is not routinely performed due to its disadvantage in terms of time consumption and not accurate results for micro-metastasis detection (65% of detection accuracy) thereby losing part of the techniques potential.

In laparoscopic cholecystectomy, the critical view of safety (CVS) has been described to reduce the risk of bile duct injury. We aim to adapt concepts of "culture of safety" to laparoscopic SLN node dissection by identifying key anatomic landmarks and structures, in various scenarios, that could prevent intra- operative injuries and enhance the mapping rate by following the standardized surgical steps.

Therefore, quantifying and studying intraoperative events such as the rate of achieving the recommended surgical steps, would enable the examination of how best to implement guideline recommendations and seek new solutions to reduce operative risks. Furthermore, these videos could be utilized to train and validate artificial intelligence (AI) algorithms, with the potential to assist surgeons in the operating room helping in the training to reach faster the learning curve and improve the procedural safety. Infact, recent AI algorithms capable of automatically assessing and documenting the critical view of safety (CVS) with short videos could be utilized to support the implementation of guidelines and make laparoscopic SLN dissection safer.

Analyzing videos of laparoscopic SLN dissection performed at referral centers could help assess the implementation of a stepwise approach to the procedure and the development of a critical view of safety (CVS) along with other guideline recommendations, as well as develop new solutions for safe laparoscopic SLN dissection. The steps to identification and the "Critical view of safety" are fully described in the study. Our project emphasizes the importance of achieving these views of safety before proceeding to the next step of the procedure. The next step involves analysing the intensity of the fluorescent signal and correlating it, as no-one has ever done, with the histological diagnosis of the sentinel lymph node to assess the possibility of correlation between intensity and metastatic nature.

Additionally, AI algorithms for safe laparoscopic SLN dissection could be tested on the collected videos from multiple hospital centers to adequately study the generalizability of these algorithms before clinical translation.

Purposes and objective of the clinical study:

The objective of this study is to establish the rate of critical view of safety (CVS) for safe laparoscopic SLN dissection in a multicentre cohort of surgical videos to reduce complications, the surgical learning curve and correlate ICG intensity with the lymph node metastatic nature

Conditions

Endometrial Cancer; Cervical Cancer; Deep Learning; Artificial Intelligence

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Interventions

Sentinel lymph node sampling

video analysis

Intervention Type: PROCEDURE

Other Intervention Names

sentinel lymph node detection; sentinel lymph node dissection; sentinel lymph node biopsy

Eligibility Criteria

Inclusion Criteria

• Women undergoing MIS sentinel lymph node dissection for endometrial or cervical cancers
• Availability of video
• Age >18 years
• Willingness to participate in the study and to provide informed consent

Exclusion Criteria

• Previous pelvic radiotherapy treatments
• Severe endometriosis or other conditions able to alter the pelvic anatomy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 99 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

IHU Strasbourg

OTHER

Sponsor Role: collaborator

University Hospital, Strasbourg

OTHER

Sponsor Role: collaborator

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

OTHER

Sponsor Role: lead

Responsible Party

Bizzarri Nicolò

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Matteo PAVONE, MD

Role: PRINCIPAL_INVESTIGATOR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy; IHU Strasbourg; IRCAD Strasbourg; Icube Strasbourg;

Nicolò BIZZARRI, MD

Role: PRINCIPAL_INVESTIGATOR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Lise LECOINTRE, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospitals of Starsbourg; Icube Strasbourg; IHU Strasbourg

Denis QUERLEU, MD, PhD

Role: STUDY_CHAIR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Nicolas PADOY, PhD

Role: STUDY_CHAIR

IHU Strasbourg

Giovanni SCAMBIA, MD, PhD

Role: STUDY_DIRECTOR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Francesco FANFANI, MD, PhD

Role: STUDY_CHAIR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Cherif AKLADIOS, MD, PhD

Role: STUDY_CHAIR

University Hospitals of Strasbourg

Pietro MASCAGNI, MD, PhD

Role: STUDY_CHAIR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Valentina IACOBELLI, MD

Role: STUDY_CHAIR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Andrea ROSATI, MD

Role: STUDY_CHAIR

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Italy

Locations

Fondazione Policlinico Universitario A. Gemelli IRCCS

Roma, , Italy

Site Status: RECRUITING

Fondazione Policlinico Universitario A. Gemelli IRCCS

Rome, , Italy

Site Status: RECRUITING

Countries

Italy

Central Contacts

Matteo PAVONE, MD

Role: CONTACT

matteo.pavone@guest.policlinicogemelli.it

00390630151

Facility Contacts

Matteo Pavone, MD

Role: primary

00390630151

Other Identifiers

ID 6672

Identifier Type: -

Identifier Source: org_study_id