Incidence of Stomach Fullness and Associated Factors in Elective Surgical Patients
NCT ID: NCT06606782
Last Updated: 2024-09-23
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
Recruitment Status
COMPLETED
Total Enrollment
404 participants
Study Classification
OBSERVATIONAL
Study Start Date
2020-10-05
Study Completion Date
2022-10-10
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The aim of this prospective, observational study is to evaluate the incidence of residual gastric content in elective surgical patients who adhered to preoperative fasting guidelines and to investigate associated patient-related factors. Ultrasound (USG) has been identified as a valuable tool for assessing residual gastric content, and this study compares its efficacy against traditional questionnaire-based predictions. The study also examines the practicality and accuracy of different gastric volume estimation formulas and evaluates their correlation with aspiration risk.
A total of 475 patients were enrolled in the study, of whom 404 completed both the questionnaire and USG examination. All participants were adult patients scheduled for elective surgery, following standard fasting protocols. The ultrasound examination assessed the presence of solid or fluid content in the stomach, and patients were classified according to qualitative Perlas risk scores (Grade 0: Low, Grade 1: Moderate, Grade 2: High risk of aspiration). The questionnaire collected patient-reported factors, such as symptoms of early satiety, history of cholelithiasis, and comorbidities like diabetes or chronic obstructive pulmonary disease (COPD).
The primary objective of this study was to evaluate the efficacy of USG in detecting residual gastric content and compare it with questionnaire-based risk predictions. Logistic regression analysis identified early satiety and cholelithiasis as significant predictors of a full stomach and higher aspiration risk. Fasting duration was found to have a protective effect, reducing the likelihood of a full stomach. While many patient characteristics traditionally associated with delayed gastric emptying, such as age and diabetes, did not significantly correlate with the outcomes, early satiety and cholelithiasis proved to be key factors influencing gastric content.
In addition, this study explored the performance of several gastric volume estimation formulas, including the Michiko, Bouvet, and Perlas 2019/2020 formulas. The findings indicated significant limitations in these formulas, with many patients being estimated to have negative gastric volumes, particularly by the Michiko and two of Perlas\' formulas. This highlights the inadequacies of current formulas in accurately predicting gastric volume, necessitating further refinement and development of new models that better account for physiological variability.
Furthermore, the agreement between questionnaire-based predictions and USG findings was assessed using Cohen's Kappa, which indicated fair agreement (Kappa value = 0.282). This suggests that while the questionnaire can serve as a screening tool to identify patients at risk of aspiration, it cannot replace the accuracy and reliability of USG in clinical practice.
Secondary objectives of the study included comparing the time-efficiency and ease of implementation between USG and the questionnaire-based assessments. USG proved to be more time-efficient, taking an average of 2.5 minutes per examination, compared to 3-5 minutes for completing the questionnaire. This speed, combined with its objective nature, underscores USG's value as a practical tool in the preoperative setting.
In conclusion, USG was found to be an effective and efficient tool for assessing residual gastric content and predicting aspiration risk, outperforming traditional questionnaire-based assessments. The inadequacy of current gastric volume estimation formulas points to the need for further research to develop more accurate and context-specific assessment tools. Comprehensive preoperative evaluation incorporating USG and patient-reported symptoms may improve patient safety by reducing the risk of aspiration during elective surgery.
A total of 475 patients were enrolled in the study, of whom 404 completed both the questionnaire and USG examination. All participants were adult patients scheduled for elective surgery, following standard fasting protocols. The ultrasound examination assessed the presence of solid or fluid content in the stomach, and patients were classified according to qualitative Perlas risk scores (Grade 0: Low, Grade 1: Moderate, Grade 2: High risk of aspiration). The questionnaire collected patient-reported factors, such as symptoms of early satiety, history of cholelithiasis, and comorbidities like diabetes or chronic obstructive pulmonary disease (COPD).
The primary objective of this study was to evaluate the efficacy of USG in detecting residual gastric content and compare it with questionnaire-based risk predictions. Logistic regression analysis identified early satiety and cholelithiasis as significant predictors of a full stomach and higher aspiration risk. Fasting duration was found to have a protective effect, reducing the likelihood of a full stomach. While many patient characteristics traditionally associated with delayed gastric emptying, such as age and diabetes, did not significantly correlate with the outcomes, early satiety and cholelithiasis proved to be key factors influencing gastric content.
In addition, this study explored the performance of several gastric volume estimation formulas, including the Michiko, Bouvet, and Perlas 2019/2020 formulas. The findings indicated significant limitations in these formulas, with many patients being estimated to have negative gastric volumes, particularly by the Michiko and two of Perlas\' formulas. This highlights the inadequacies of current formulas in accurately predicting gastric volume, necessitating further refinement and development of new models that better account for physiological variability.
Furthermore, the agreement between questionnaire-based predictions and USG findings was assessed using Cohen's Kappa, which indicated fair agreement (Kappa value = 0.282). This suggests that while the questionnaire can serve as a screening tool to identify patients at risk of aspiration, it cannot replace the accuracy and reliability of USG in clinical practice.
Secondary objectives of the study included comparing the time-efficiency and ease of implementation between USG and the questionnaire-based assessments. USG proved to be more time-efficient, taking an average of 2.5 minutes per examination, compared to 3-5 minutes for completing the questionnaire. This speed, combined with its objective nature, underscores USG's value as a practical tool in the preoperative setting.
In conclusion, USG was found to be an effective and efficient tool for assessing residual gastric content and predicting aspiration risk, outperforming traditional questionnaire-based assessments. The inadequacy of current gastric volume estimation formulas points to the need for further research to develop more accurate and context-specific assessment tools. Comprehensive preoperative evaluation incorporating USG and patient-reported symptoms may improve patient safety by reducing the risk of aspiration during elective surgery.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Point-of-care Gastric Ultrasound for Fracture Surgery
NCT05728242
Pneumonia, Aspiration
Gastric Content
Fractures, Bone
RECRUITING
Gastric Emptying Time After Turkish Breakfast
NCT04789785
Fasting
COMPLETED
Preoperative Residual Gastric Volume
NCT07031414
Preoperative
Gastric
Residual Volume
ACTIVE_NOT_RECRUITING
Preoperative Presence of Gastric Content in Non-fasting Patients - an Ultrasound Study
NCT03685435
Non-fasting Patients
Rapid Sequence Intubation
Anesthesia Intubation Complication
COMPLETED
Evaluation of the Effect of APFEL Risk Score and Fasting Periods on Postoperative Nausea and/or Vomiting
NCT06022705
Nausea, Postoperative
Vomiting, Postoperative
APFEL RİSK SCORE
COMPLETED
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
This study is a prospective observational research project designed to evaluate the incidence of residual gastric content in patients scheduled for elective surgery and to investigate patient-related factors that influence gastric emptying. The study primarily employs ultrasonography (USG) as a tool for assessing the presence of residual gastric content and compares its efficacy with traditional questionnaire-based assessments. Additionally, the study examines the utility and accuracy of various gastric volume estimation formulas, assessing their correlation with observed gastric content and aspiration risk.
Study Design:
Participants were enrolled based on pre-defined inclusion and exclusion criteria, including adult patients scheduled for elective surgery who adhered to standard preoperative fasting guidelines. Following a detailed informed consent process, patients were asked to complete a preoperative questionnaire, which gathered data on demographic characteristics, medical history, and patient-reported symptoms, such as early satiety, history of cholelithiasis, and other relevant comorbidities. Ultrasound examinations were performed by a single trained investigator to ensure consistency in imaging and interpretation.
USG was utilized to assess residual gastric content, including both solid and fluid content. The antrum cross-sectional area was measured in the supine and right lateral decubitus positions, and gastric volume was estimated using four different formulas: Michiko, Bouvet, two fo Perlas\' formulas developed in differnet investigations. Patients were classified into three groups according to the Perlas risk score, which is based on ultrasound findings of gastric content (Grade 0 = low risk, Grade 1 = moderate risk, Grade 2 = high risk of aspiration). The primary outcome was the identification of a full stomach, defined as the presence of solid content or fluid contentbased on ultrasound findings.
Registry Procedures and Quality Control:
Quality assurance procedures were integrated into the study to ensure the reliability of both questionnaire-based data and ultrasound findings. The following processes were implemented:
1. Data Validation: All questionnaire responses and ultrasound measurements were reviewed for consistency and completeness. In the event of data entry errors or inconsistencies, the original data sources (questionnaires or ultrasound logs) were consulted for clarification and correction.
2. Source Data Verification: Ultrasound findings were periodically cross-referenced with patient charts and medical records to verify the accuracy of reported comorbidities and other patient characteristics.
3. Data Dictionary and Coding: The study utilized a detailed data dictionary for all variables, including categorical coding for risk factors, comorbidities, and ultrasound findings. For example, the World Health Organization's MedDRA coding was used for medical conditions, and normal ranges for fasting times and antrum cross-sectional area were predefined based on existing literature.
4. Standard Operating Procedures (SOPs): SOPs were developed for patient recruitment, ultrasound measurements, data collection, data management, and data analysis. These procedures included regular checks for missing or incomplete data, predefined criteria for image quality in ultrasound readings, and protocols for identifying and addressing any out-of-range results.
Sample Size Assessment:
A sample size of 207 patients was calculated using the G-Power program (version 3.1.9.7), with the degrees of freedom set to 3 and an effect size of 0.3. This sample size was based on examining two patient groups with a categorical variable containing four categories, with a type I error rate of 0.05 and a type II error rate of 0.1. To account for subgroup analyses and potential registration errors, a target of at least 300 patients was set. The final number of patients completing both the questionnaire and ultrasound was 404.
Plan for Missing Data:
To address missing data, the following strategies were implemented:
* Any incomplete questionnaire responses were flagged, and patients were contacted to complete the missing information, where possible.
* Missing ultrasound measurements were rare, but if ultrasound images were deemed inadequate (e.g., poor image quality or patient inability to tolerate positioning), these patients were excluded from the specific analyses.
* For missing or inconsistent values, a complete-case analysis was employed, excluding individuals from specific models if key variables were not available.
* Sensitivity analyses were conducted to assess the impact of missing data on the final results.
Statistical Analysis Plan:
Data analysis was conducted using R statistical software (version 4.1.2). Statistical techniques were selected based on the study objectives:
1. Primary Objective (USG Efficacy):
* Logistic regression models were employed to assess the relationship between patient characteristics (e.g., early satiety, cholelithiasis) and full stomach based on USG findings. The dependent variable was the binary outcome of full stomach vs. empty stomach.
* Qualitative scoring based on the Perlas risk score was incorporated to evaluate aspiration risk, with separate logistic models developed to predict Grade 0 (low risk), Grade 1 (moderate risk), and Grade 2 (high risk).
* Model performance was assessed using the area under the receiver operating characteristic (ROC) curve (AUC), and the optimal cutoff points were determined using Youden's index to balance sensitivity and specificity.
2. Secondary Objective (Questionnaire vs. USG):
* Cohen's Kappa statistic was used to assess agreement between questionnaire-based predictions and USG findings. This analysis aimed to determine how well the questionnaire could predict residual gastric content and aspiration risk compared to USG.
* Time-efficiency was analyzed by comparing the average duration of completing the questionnaire (3-5 minutes) vs. the ultrasound examination (2.5 minutes).
3. Gastric Volume Estimation Formulas:
* Correlation coefficients (Spearman's rank) were calculated to determine the association between estimated gastric volumes from the four formulas (Michiko, Bouvet, two of Perlas\' formulas) and the ultrasound findings (full stomach and aspiration risk).
* Logistic regression models were developed to evaluate whether the estimated gastric volumes from each formula were significant predictors of full stomach or aspiration risk. Negative or non-significant results were flagged as indicators of formula limitations.
4. Adjusted Models:
* Multivariate models adjusting for potential confounders (e.g., age, sex, comorbidities such as diabetes) were developed to ensure that observed associations between patient characteristics and gastric content or risk were not confounded by other variables.
* A complete-case analysis was performed for all multivariate models, excluding patients with missing values for any of the key variables.
Limitations:
The study acknowledges several limitations. First, no direct measurement of gastric volume was obtained through orogastric tube aspiration, limiting the ability to definitively compare USG findings to a gold standard. Second, the analysis was constrained by the relatively small number of patients (n = 57) for whom volume estimation was possible, particularly due to negative or invalid results from the gastric volume formulas. Lastly, the study was performed in a single center, and all ultrasound measurements were conducted by a single investigator, which, while minimizing inter-operator variability, may limit the generalizability of the findings to other settings.
Future Directions:
Future studies should focus on refining the gastric volume estimation formulas and exploring additional patient-reported symptoms and clinical factors that may affect gastric emptying. There is also a need to standardize ultrasound protocols and validate the findings in a multi-center, diverse patient population. In addition, comparisons with other preoperative risk assessment tools, such as orogastric tube suction, should be explored.
Study Design:
Participants were enrolled based on pre-defined inclusion and exclusion criteria, including adult patients scheduled for elective surgery who adhered to standard preoperative fasting guidelines. Following a detailed informed consent process, patients were asked to complete a preoperative questionnaire, which gathered data on demographic characteristics, medical history, and patient-reported symptoms, such as early satiety, history of cholelithiasis, and other relevant comorbidities. Ultrasound examinations were performed by a single trained investigator to ensure consistency in imaging and interpretation.
USG was utilized to assess residual gastric content, including both solid and fluid content. The antrum cross-sectional area was measured in the supine and right lateral decubitus positions, and gastric volume was estimated using four different formulas: Michiko, Bouvet, two fo Perlas\' formulas developed in differnet investigations. Patients were classified into three groups according to the Perlas risk score, which is based on ultrasound findings of gastric content (Grade 0 = low risk, Grade 1 = moderate risk, Grade 2 = high risk of aspiration). The primary outcome was the identification of a full stomach, defined as the presence of solid content or fluid contentbased on ultrasound findings.
Registry Procedures and Quality Control:
Quality assurance procedures were integrated into the study to ensure the reliability of both questionnaire-based data and ultrasound findings. The following processes were implemented:
1. Data Validation: All questionnaire responses and ultrasound measurements were reviewed for consistency and completeness. In the event of data entry errors or inconsistencies, the original data sources (questionnaires or ultrasound logs) were consulted for clarification and correction.
2. Source Data Verification: Ultrasound findings were periodically cross-referenced with patient charts and medical records to verify the accuracy of reported comorbidities and other patient characteristics.
3. Data Dictionary and Coding: The study utilized a detailed data dictionary for all variables, including categorical coding for risk factors, comorbidities, and ultrasound findings. For example, the World Health Organization's MedDRA coding was used for medical conditions, and normal ranges for fasting times and antrum cross-sectional area were predefined based on existing literature.
4. Standard Operating Procedures (SOPs): SOPs were developed for patient recruitment, ultrasound measurements, data collection, data management, and data analysis. These procedures included regular checks for missing or incomplete data, predefined criteria for image quality in ultrasound readings, and protocols for identifying and addressing any out-of-range results.
Sample Size Assessment:
A sample size of 207 patients was calculated using the G-Power program (version 3.1.9.7), with the degrees of freedom set to 3 and an effect size of 0.3. This sample size was based on examining two patient groups with a categorical variable containing four categories, with a type I error rate of 0.05 and a type II error rate of 0.1. To account for subgroup analyses and potential registration errors, a target of at least 300 patients was set. The final number of patients completing both the questionnaire and ultrasound was 404.
Plan for Missing Data:
To address missing data, the following strategies were implemented:
* Any incomplete questionnaire responses were flagged, and patients were contacted to complete the missing information, where possible.
* Missing ultrasound measurements were rare, but if ultrasound images were deemed inadequate (e.g., poor image quality or patient inability to tolerate positioning), these patients were excluded from the specific analyses.
* For missing or inconsistent values, a complete-case analysis was employed, excluding individuals from specific models if key variables were not available.
* Sensitivity analyses were conducted to assess the impact of missing data on the final results.
Statistical Analysis Plan:
Data analysis was conducted using R statistical software (version 4.1.2). Statistical techniques were selected based on the study objectives:
1. Primary Objective (USG Efficacy):
* Logistic regression models were employed to assess the relationship between patient characteristics (e.g., early satiety, cholelithiasis) and full stomach based on USG findings. The dependent variable was the binary outcome of full stomach vs. empty stomach.
* Qualitative scoring based on the Perlas risk score was incorporated to evaluate aspiration risk, with separate logistic models developed to predict Grade 0 (low risk), Grade 1 (moderate risk), and Grade 2 (high risk).
* Model performance was assessed using the area under the receiver operating characteristic (ROC) curve (AUC), and the optimal cutoff points were determined using Youden's index to balance sensitivity and specificity.
2. Secondary Objective (Questionnaire vs. USG):
* Cohen's Kappa statistic was used to assess agreement between questionnaire-based predictions and USG findings. This analysis aimed to determine how well the questionnaire could predict residual gastric content and aspiration risk compared to USG.
* Time-efficiency was analyzed by comparing the average duration of completing the questionnaire (3-5 minutes) vs. the ultrasound examination (2.5 minutes).
3. Gastric Volume Estimation Formulas:
* Correlation coefficients (Spearman's rank) were calculated to determine the association between estimated gastric volumes from the four formulas (Michiko, Bouvet, two of Perlas\' formulas) and the ultrasound findings (full stomach and aspiration risk).
* Logistic regression models were developed to evaluate whether the estimated gastric volumes from each formula were significant predictors of full stomach or aspiration risk. Negative or non-significant results were flagged as indicators of formula limitations.
4. Adjusted Models:
* Multivariate models adjusting for potential confounders (e.g., age, sex, comorbidities such as diabetes) were developed to ensure that observed associations between patient characteristics and gastric content or risk were not confounded by other variables.
* A complete-case analysis was performed for all multivariate models, excluding patients with missing values for any of the key variables.
Limitations:
The study acknowledges several limitations. First, no direct measurement of gastric volume was obtained through orogastric tube aspiration, limiting the ability to definitively compare USG findings to a gold standard. Second, the analysis was constrained by the relatively small number of patients (n = 57) for whom volume estimation was possible, particularly due to negative or invalid results from the gastric volume formulas. Lastly, the study was performed in a single center, and all ultrasound measurements were conducted by a single investigator, which, while minimizing inter-operator variability, may limit the generalizability of the findings to other settings.
Future Directions:
Future studies should focus on refining the gastric volume estimation formulas and exploring additional patient-reported symptoms and clinical factors that may affect gastric emptying. There is also a need to standardize ultrasound protocols and validate the findings in a multi-center, diverse patient population. In addition, comparisons with other preoperative risk assessment tools, such as orogastric tube suction, should be explored.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Gastric Emptying
Preoperative Care
Preoperative Fasting
Elective Surgical Procedures
Ultrasonography
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
Observational Model Type
COHORT
Study Time Perspective
PROSPECTIVE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Elective Surgery Patients
This cohort includes adult patients undergoing elective surgery who were assessed for residual gastric content using ultrasound and a preoperative questionnaire. All patients adhered to standard preoperative fasting guidelines prior to the assessment.
No interventions assigned to this group
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* scheduled for elective surgery
* adhered to preoperative fasting guidelines
* provided written informed consent
* adhered to preoperative fasting guidelines
* provided written informed consent
Exclusion Criteria
* children under 18 years of age
* pregnant women
* patients requiring emergency surgery
* patients with a history of previous stomach surgery
* patients who did not complete the sufficient fasting period (less than 8 hours)
* patients with whom reliable cooperation for questionnaire completion could not be established (e.g., inability to provide reliable answers)
* patients who could not be positioned on their right side due to clinical conditions
* patients in whom sufficient quality imaging of the gastric antrum could not be obtained
* pregnant women
* patients requiring emergency surgery
* patients with a history of previous stomach surgery
* patients who did not complete the sufficient fasting period (less than 8 hours)
* patients with whom reliable cooperation for questionnaire completion could not be established (e.g., inability to provide reliable answers)
* patients who could not be positioned on their right side due to clinical conditions
* patients in whom sufficient quality imaging of the gastric antrum could not be obtained
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Recep Tayyip Erdogan University
OTHER
Sponsor Role
lead
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Başar Erdivanlı
Assoc. Prof.
Responsibility Role
PRINCIPAL_INVESTIGATOR
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Recep Tayyip Erdoğan University Rize Training and Research Hospital
Rize, , Turkey (Türkiye)
Site Status
Countries
Review the countries where the study has at least one active or historical site.
Turkey (Türkiye)
References
Explore related publications, articles, or registry entries linked to this study.
Sugita M, Matsumoto M, Tsukano Y, Fukunaga C, Yamamoto T. Gastric emptying time after breakfast in healthy adult volunteers using ultrasonography. J Anesth. 2019 Dec;33(6):697-700. doi: 10.1007/s00540-019-02694-6. Epub 2019 Oct 19.
Reference Type
BACKGROUND
Bouvet L, Mazoit JX, Chassard D, Allaouchiche B, Boselli E, Benhamou D. Clinical assessment of the ultrasonographic measurement of antral area for estimating preoperative gastric content and volume. Anesthesiology. 2011 May;114(5):1086-92. doi: 10.1097/ALN.0b013e31820dee48.
Reference Type
BACKGROUND
Perlas A, Davis L, Khan M, Mitsakakis N, Chan VW. Gastric sonography in the fasted surgical patient: a prospective descriptive study. Anesth Analg. 2011 Jul;113(1):93-7. doi: 10.1213/ANE.0b013e31821b98c0. Epub 2011 May 19.
Reference Type
BACKGROUND
Perlas A, Mitsakakis N, Liu L, Cino M, Haldipur N, Davis L, Cubillos J, Chan V. Validation of a mathematical model for ultrasound assessment of gastric volume by gastroscopic examination. Anesth Analg. 2013 Feb;116(2):357-63. doi: 10.1213/ANE.0b013e318274fc19. Epub 2013 Jan 9.
Reference Type
BACKGROUND
Bouvet L, Desgranges FP, Aubergy C, Boselli E, Dupont G, Allaouchiche B, Chassard D. Prevalence and factors predictive of full stomach in elective and emergency surgical patients: a prospective cohort study. Br J Anaesth. 2017 Mar 1;118(3):372-379. doi: 10.1093/bja/aew462.
Reference Type
BACKGROUND
Perlas A, Arzola C, Van de Putte P. Point-of-care gastric ultrasound and aspiration risk assessment: a narrative review. Can J Anaesth. 2018 Apr;65(4):437-448. doi: 10.1007/s12630-017-1031-9. Epub 2017 Dec 11.
Reference Type
BACKGROUND
El-Boghdadly K, Wojcikiewicz T, Perlas A. Perioperative point-of-care gastric ultrasound. BJA Educ. 2019 Jul;19(7):219-226. doi: 10.1016/j.bjae.2019.03.003. Epub 2019 Apr 24. No abstract available.
Reference Type
BACKGROUND
Goyal RK, Cristofaro V, Sullivan MP. Rapid gastric emptying in diabetes mellitus: Pathophysiology and clinical importance. J Diabetes Complications. 2019 Nov;33(11):107414. doi: 10.1016/j.jdiacomp.2019.107414. Epub 2019 Aug 8.
Reference Type
BACKGROUND
Zhou L, Yang Y, Yang L, Cao W, Jing H, Xu Y, Jiang X, Xu D, Xiao Q, Jiang C, Bo L. Point-of-care ultrasound defines gastric content in elective surgical patients with type 2 diabetes mellitus: a prospective cohort study. BMC Anesthesiol. 2019 Oct 10;19(1):179. doi: 10.1186/s12871-019-0848-x.
Reference Type
BACKGROUND
Chang JE, Kim H, Won D, Lee JM, Jung JY, Min SW, Hwang JY. Ultrasound assessment of gastric content in fasted patients before elective laparoscopic cholecystectomy: a prospective observational single-cohort study. Can J Anaesth. 2020 Jul;67(7):810-816. doi: 10.1007/s12630-020-01668-7. Epub 2020 Apr 20.
Reference Type
BACKGROUND
Nguyen L, Wilson LA, Miriel L, Pasricha PJ, Kuo B, Hasler WL, McCallum RW, Sarosiek I, Koch KL, Snape WJ, Farrugia G, Grover M, Clarke J, Parkman HP, Tonascia J, Hamilton F, Abell TL; NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with etiology, gastric emptying, and symptom severity. Neurogastroenterol Motil. 2020 Aug;32(8):e13810. doi: 10.1111/nmo.13810. Epub 2020 Feb 15.
Reference Type
BACKGROUND
Syed AR, Wolfe MM, Calles-Escandon J. Epidemiology and Diagnosis of Gastroparesis in the United States: A Population-based Study. J Clin Gastroenterol. 2020 Jan;54(1):50-54. doi: 10.1097/MCG.0000000000001231.
Reference Type
BACKGROUND
Goyal RK. Gastric Emptying Abnormalities in Diabetes Mellitus. N Engl J Med. 2021 May 6;384(18):1742-1751. doi: 10.1056/NEJMra2020927. No abstract available.
Reference Type
BACKGROUND
Shaw M, Waiting J, Barraclough L, Ting K, Jeans J, Black B; Pan-London Peri-operative Audit and Research Network. Airway events in obese vs. non-obese elective surgical patients: a cross-sectional observational study. Anaesthesia. 2021 Dec;76(12):1585-1592. doi: 10.1111/anae.15513. Epub 2021 Jun 22.
Reference Type
BACKGROUND
Sun J, Wei G, Hu L, Liu C, Ding Z. Perioperative pulmonary aspiration and regurgitation without aspiration in adults: a retrospective observational study of 166,491 anesthesia records. Ann Palliat Med. 2021 Apr;10(4):4037-4046. doi: 10.21037/apm-20-2382. Epub 2021 Mar 23.
Reference Type
BACKGROUND
Warner MA, Meyerhoff KL, Warner ME, Posner KL, Stephens L, Domino KB. Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis. Anesthesiology. 2021 Aug 1;135(2):284-291. doi: 10.1097/ALN.0000000000003831.
Reference Type
BACKGROUND
Assmus F, Hoglund RM, Monnot F, Specht S, Scandale I, Tarning J. Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside. PLoS Negl Trop Dis. 2022 Mar 10;16(3):e0010219. doi: 10.1371/journal.pntd.0010219. eCollection 2022 Mar.
Reference Type
BACKGROUND
Frykholm P, Disma N, Andersson H, Beck C, Bouvet L, Cercueil E, Elliott E, Hofmann J, Isserman R, Klaucane A, Kuhn F, de Queiroz Siqueira M, Rosen D, Rudolph D, Schmidt AR, Schmitz A, Stocki D, Sumpelmann R, Stricker PA, Thomas M, Veyckemans F, Afshari A. Pre-operative fasting in children: A guideline from the European Society of Anaesthesiology and Intensive Care. Eur J Anaesthesiol. 2022 Jan 1;39(1):4-25. doi: 10.1097/EJA.0000000000001599.
Reference Type
BACKGROUND
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
2020/202
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.
Can the Effects of High Flow Nasal Cannula Oxygenation on Postoperative Atelectasis be Evaluated With Lung Ultrasound
NCT03828513
ACTIVE_NOT_RECRUITING
NA
Ultrasonography in Predicting Difficult Intubation in Obese Emergency Surgical Patients
NCT05109221
UNKNOWN
Verification of Endotracheal Tube Placement With Ultrasonography (USG)
NCT03081221
COMPLETED
Ultrasonographic Comparison of Gastric Volume After Three Modes of Positive Facemask During Induction of Anaesthesia
NCT02906267
UNKNOWN
NA
Assessment Of Difficult Airway Predictors: A Prospective Comparison Of Upper Airway Ultrasound And Conventional Anthropometric Measures
NCT07309978
NOT_YET_RECRUITING
Evaluation of Anterior Neck Ultrasound in Predicting Difficult Airway in Obese Patients
NCT07346768
NOT_YET_RECRUITING
Evaluation of the Effects of Different Ventilation Modes Used During Anesthesia Awakening on the Frequency of Postoperative Atelectasis
NCT06358027
NOT_YET_RECRUITING
Ultrasound in Evaluation of Preoperative Fluid Management of Hip Fracture Surgery Patients
NCT05916599
UNKNOWN
Diagnostic Values of Physical Examination and Ultrasonographic Measurements in Predicting Difficult Airways
NCT06611917
COMPLETED
Difficult Airway and Ultrasonographic Evaluation
NCT05347121
COMPLETED
Comparison of the Effect of Supine and Prone Position on the Ultrasonographic Airway Measurements
NCT05197400
COMPLETED
NA
Comparison of the Effect of Two Methods on Laryngeal Edema in Endotracheal Cuff Inflation
NCT06770322
COMPLETED
NA
Evaluation Of One Lung Ventilation With Ultrasound in Thorax Surgery Operations
NCT06064773
COMPLETED
Comparison of PEEP Effect on Perioperative Oxygenation and Postoperative Pulmonary Complications in Lithotomy Position
NCT05261295
UNKNOWN
Effect of Hot Pack Application on Gastrointestinal Motility After Abdominal Surgery
NCT06892782
NOT_YET_RECRUITING
NA
Success of ChatGPT in Determining the Need for Postoperative Intensive Care
NCT06321328
COMPLETED
Effectiveness of Ultrasonography and The Cole Formula on the Evaluation of the Appropriate Endotracheal Tube Size
NCT03280498
COMPLETED
NA
Effect of Different Peep Values on Gastric Residual Volume
NCT06371378
COMPLETED
NA
The Effect of Early Mobilization on Postoperative Recovery in Abdominal Surgery
NCT06053957
COMPLETED
NA
Effect of Reflective Blanket on Undesirable Perioperative Hypothermia
NCT05702320
UNKNOWN
NA
The Effect of Mobilization on Gastric Emptying Time
NCT05981638
COMPLETED
NA
The Effects of Active Warming on Temperature on Core Body and Thermal Comfort
NCT04985617
COMPLETED
NA
Effects of General Health Risk Factors on Prolonged Hospital Stay
NCT06810232
ENROLLING_BY_INVITATION