A Study Evaluating the Safety, Tolerability, and Efficacy of EVO756 in Adults With Chronic Inducible Urticaria

NCT ID: NCT06603220

Last Updated: 2025-06-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-14

Study Completion Date

2025-05-08

Brief Summary

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This phase 2a trial will evaluate the safety and efficacy of EVO756 in subjects with chronic inducible urticaria, including symptomatic dermographism and cold urticaria.

Detailed Description

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Conditions

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Chronic Inducible Urticaria

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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EVO756

Group Type EXPERIMENTAL

Oral EVO756

Intervention Type DRUG

Oral EVO756, once daily

Interventions

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Oral EVO756

Oral EVO756, once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of chronic inducible urticaria for at least 3 months.
* Positive response following provocation using the TempTest or FricTest at Screening and Day 1.

Exclusion Criteria

* History of diseases other than chronic inducible urticaria or chronic spontaneous urticaria with urticaria or angioedema symptoms, such as urticarial vasculitis, erythema multiforme, cutaneous mastocytosis (urticaria pigmentosa), and hereditary or acquired angioedema.
* Concurrent use of certain medications, including antihistamines.
* Any clinically significant disease, or other skin disease or skin markings (e.g., extensive scarring, tattoos), that might confound the evaluation of safety or efficacy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Evommune, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Cahaba Dermatology & Skin Health Center, LLC

Birmingham, Alabama, United States

Site Status

California Allergy and Asthma Medical Group

Los Angeles, California, United States

Site Status

Integrative Skin Science and Research

Sacramento, California, United States

Site Status

West Dermatology Research Center

San Diego, California, United States

Site Status

Advanced Clinical Research Institute

Tampa, Florida, United States

Site Status

Aeroallergy Research Laboratories of Savannah, Inc.

Savannah, Georgia, United States

Site Status

Treasure Valley Medical Research

Boise, Idaho, United States

Site Status

Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, United States

Site Status

Southern Indiana Clinical Trials

New Albany, Indiana, United States

Site Status

Indiana Clinical Trials Center, P.C.

Plainfield, Indiana, United States

Site Status

DelRicht Research

Baton Rouge, Louisiana, United States

Site Status

Chesapeake Clinical Research, Inc

White Marsh, Maryland, United States

Site Status

OptiSkin Medical

New York, New York, United States

Site Status

Red River Research Partners

Fargo, North Dakota, United States

Site Status

Bexley Dermatology Research

Bexley, Ohio, United States

Site Status

Allergy, Asthma, and Clinical Research Center

Oklahoma City, Oklahoma, United States

Site Status

Allergy and Clinical Immunology Associates

Pittsburgh, Pennsylvania, United States

Site Status

Austin Institute for Clinical Research

Pflugerville, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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EVO756-CIU001

Identifier Type: -

Identifier Source: org_study_id

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