Effect of Clinical and Biochemical Variables Over Morbidity and Mortality in Alcohol Withdrawal Syndrome Patients

NCT ID: NCT06589973

Last Updated: 2024-09-19

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 195 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-09-09
• Study Completion Date: 2025-02-28

Brief Summary

The goal of this observational study is to describe the impact measured through the Odds Ratio (OR) of different variables of clinical and biochemical alterations on the duration of the syndrome alcohol withdrawal patients measured in days of symptoms and stay; it could include any patients with a diagnosis of admission of alcohol withdrawal syndrome (AWS) who have been treated in the department of Internal Medicine for 5 years.

The main question it aims to answer is: What is the relationship between the different clinical, biochemical, and hematic factors on the duration of symptoms, morbidity, and mortality in individuals with alcohol syndrome withdrawal?

• If the patient has a greater number of risk factors, such as advanced age, a long and chronic history of alcohol consumption, the type of distillate consumed, as well as the deterioration of liver function and presence of leukocytosis and neutrophilia, then it is postulated that the duration of alcohol withdrawal syndrome will be longer.

Clinical records will be used to describe the proportion of complications associated with alcohol withdrawal syndrome including pneumonia bronchial aspiration, seizures, need for mechanical ventilation, digestive tract hemorrhage, toxic-alcoholic hepatitis, and pancreatitis.

Detailed Description

Clinical records (files) of patients with a diagnosis of admission of alcohol withdrawal syndrome (AAS) who have been treated in the Department of Internal Medicine for 5 years.

Conditions

Alcohol Withdrawal Syndrome

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: OTHER

Interventions

Study Cohort

Clinical records (files) of patients with a diagnosis of admission of alcohol withdrawal syndrome (AAS) who have been treated in the Department of Internal Medicine for 5 years.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Clinical records of patients, both genders, over 18 years of age with Alcohol Withdrawal Syndrome according to the criteria for alcohol withdrawal.
• Clinical records of candidates for admission for neurological monitoring and with criteria for use of sedative drugs according to the CIWA-Ar scale
• Clinical records of patients containing the CIWA-Ar scale score at diagnosis

Exclusion Criteria

• Clinical records of patients who already have a history of seizures or epilepsy
• Clinical records of diabetic patients with diabetic ketoacidosis
• Clinical records of patients who have not received any type of sedative treatment
• Clinical records of patients with chronic liver failure or liver cirrhosis
• Clinical records of patients with chronic liver disease with signs of hepatic encephalopathy
• Clinical records of patients with related toxic-alcoholic hepatitis
• Clinical records of patients with a life expectancy of less than 24 hours due to associated complications such as head trauma or other associated complications
• Clinical records of patients who require intubation and mechanical ventilation upon admission
• Clinical records of patients who have a vascular event that modifies the neurological evaluation
• Clinical records of patients who before admission show psychomotor alteration or neurological deterioration that modifies the neurological evaluation such as the presence of Wernicke's encephalopathy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hospital General de Mexico

OTHER_GOV

Sponsor Role: lead

Responsible Party

Christian Omar Ramos-Peñafiel, MD, PhD

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hospital General de Cuautitlan "General José Vicente Villada"

Mexico City, , Mexico

Site Status: RECRUITING

Countries

Mexico

Central Contacts

Christian O Ramos Peñafiel, PhD

Role: CONTACT

leukemiachop33@gmail.com

5527892000 ext. 1420

Yossadara Hernández Ángeles, MD

Role: CONTACT

yossadara.ha@gmail.com

5523351588

Facility Contacts

Yossadara Hernández Ángeles, MD

Role: primary

yossadara.ha@gmail.com

55 5872 1754

Other Identifiers

606023-01-1624

Identifier Type: -

Identifier Source: org_study_id