Effects of Different Pressure Garments on Upper Extremity Sensorimotor Functions and Quality of Life After Stroke

NCT ID: NCT06587308

Last Updated: 2024-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

165 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-08

Study Completion Date

2026-08-31

Brief Summary

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The study aims to compare the effects of dorsal-double-layered 10% circumferential reduction (DD-10), single-layered 10% circumferential reduction (S-10), and single-layered no circumferential reduction (S-0) pressure garments on sensorimotor functions, including motor control, dexterity, muscle tone, pain, self-perceived upper extremity function, and quality of life among stroke patients during the 8 weeks of application (Time 1: Baseline, Time 2: Week 4, Time 3: Week 8).

Detailed Description

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Conditions

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Cerebral Vascular Accident (CVA)/Stroke

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

A custom-fabricated finger-to-above-elbow (long glove) pressure garment with 10% of stress. The design is similar to S-10 except it has an extra layer of fabric on the dorsal aspect that gives stronger compression

Group Type EXPERIMENTAL

Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

Intervention Type OTHER

During Phase IA, i.e., the first four weeks between Time 1 (Baseline) and Time 2 (Week 4), when participants are hospitalized in the rehabilitation department of the hospital. participants will need to wear the DD-10 pressure garment for 3 hours in the morning, 3 hours in the afternoon, and 8 hours at night daily. Additionally, all participants will need to attend an occupational therapy session for 30 minutes, 5 days a week. During Phase IB, i.e., the second four weeks between Time 2 (Week 4), and Time 3 (Week 8), when participants were being discharged from the hospital, they need to continually wearing the pressure garment according to same wearing schedule; however, the participants will not need to attend the occupational therapy session.

Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

A custom-fabricated single-layered finger-to-above-elbow (long glove) pressure garment with 10% of stress.

Group Type ACTIVE_COMPARATOR

Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

Intervention Type OTHER

During Phase IA, i.e., the first four weeks between Time 1 (Baseline) and Time 2 (Week 4), when participants are hospitalized in the rehabilitation department of the hospital. participants will need to wear the S-10 pressure garment for 3 hours in the morning, 3 hours in the afternoon, and 8 hours at night daily. Additionally, all participants will need to attend an occupational therapy session for 30 minutes, 5 days a week. During Phase IB, i.e., the second four weeks between Time 2 (Week 4), and Time 3 (Week 8), when participants were being discharged from the hospital, they need to continually wearing the pressure garment according to same wearing schedule; however, the participants will not need to attend the occupational therapy session.

Single-Layered No Circumferential Reduction (S-0) Pressure Garment

A custom-fabricated single-layered finger-to-above-elbow (long glove) pressure garment with 0% of stress

Group Type PLACEBO_COMPARATOR

Single-Layered No Circumferential Reduction (S-0) Pressure Garment

Intervention Type OTHER

During Phase IA, i.e., the first four weeks between Time 1 (Baseline) and Time 2 (Week 4), when participants are hospitalized in the rehabilitation department of the hospital. participants will need to wear the S-0 pressure garment for 3 hours in the morning, 3 hours in the afternoon, and 8 hours at night daily. Additionally, all participants will need to attend an occupational therapy session for 30 minutes, 5 days a week. During Phase IB, i.e., the second four weeks between Time 2 (Week 4), and Time 3 (Week 8), when participants were being discharged from the hospital, they need to continually wearing the pressure garment according to same wearing schedule; however, the participants will not need to attend the occupational therapy session.

Interventions

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Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

During Phase IA, i.e., the first four weeks between Time 1 (Baseline) and Time 2 (Week 4), when participants are hospitalized in the rehabilitation department of the hospital. participants will need to wear the DD-10 pressure garment for 3 hours in the morning, 3 hours in the afternoon, and 8 hours at night daily. Additionally, all participants will need to attend an occupational therapy session for 30 minutes, 5 days a week. During Phase IB, i.e., the second four weeks between Time 2 (Week 4), and Time 3 (Week 8), when participants were being discharged from the hospital, they need to continually wearing the pressure garment according to same wearing schedule; however, the participants will not need to attend the occupational therapy session.

Intervention Type OTHER

Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

During Phase IA, i.e., the first four weeks between Time 1 (Baseline) and Time 2 (Week 4), when participants are hospitalized in the rehabilitation department of the hospital. participants will need to wear the S-10 pressure garment for 3 hours in the morning, 3 hours in the afternoon, and 8 hours at night daily. Additionally, all participants will need to attend an occupational therapy session for 30 minutes, 5 days a week. During Phase IB, i.e., the second four weeks between Time 2 (Week 4), and Time 3 (Week 8), when participants were being discharged from the hospital, they need to continually wearing the pressure garment according to same wearing schedule; however, the participants will not need to attend the occupational therapy session.

Intervention Type OTHER

Single-Layered No Circumferential Reduction (S-0) Pressure Garment

During Phase IA, i.e., the first four weeks between Time 1 (Baseline) and Time 2 (Week 4), when participants are hospitalized in the rehabilitation department of the hospital. participants will need to wear the S-0 pressure garment for 3 hours in the morning, 3 hours in the afternoon, and 8 hours at night daily. Additionally, all participants will need to attend an occupational therapy session for 30 minutes, 5 days a week. During Phase IB, i.e., the second four weeks between Time 2 (Week 4), and Time 3 (Week 8), when participants were being discharged from the hospital, they need to continually wearing the pressure garment according to same wearing schedule; however, the participants will not need to attend the occupational therapy session.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Between 18 and 80 years of age
* Within 1-12 months of ischemic or hemorrhagic stroke
* First onset resulting in hemiparesis of a limb with Burnnstrom stage of 3, 4 or 5
* Modified Ashworth Scale with scores of less than or equal 2 for elbow, wrist, and hand muscle tone in the affected upper extremity
* Able to understand instruction

Exclusion Criteria

* Serious cardiovascular or respiratory diseases
* Skin lesions, infections or other skin problems
* Serious circulatory problems such as deep vein thrombosis
* Allergies or significant discomfort to pressure garment materials
* Upper extremity fractures or severe joint problems
* Severe cognitive impairment with Saint Louis University Mental Status (SLUMs) scores equal to or less than 27 (above high school level of education)/25 (below high school level of education)
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Affiliated Hospital of Shandong Second Medical University

UNKNOWN

Sponsor Role collaborator

Weifang Municipal People's Hospital

UNKNOWN

Sponsor Role collaborator

Weifang Hospital of Traditional Chinese Medicine

UNKNOWN

Sponsor Role collaborator

National University of Malaysia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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SIaw Chui Chai, PhD

Role: PRINCIPAL_INVESTIGATOR

Occupational Therapy Programme, Centre for Rehabilitation and Special Needs Studies (iCaRehab)

Locations

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The Affiliated Hospital of Shandong Second Medical University

Weifang, Shandong, China

Site Status RECRUITING

Weifang Hospital of Traditional Chinese Medicine

Weifang, Shandong, China

Site Status RECRUITING

Weifang Municipal Peoples Hospital

Weifang, Shandong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Zhenkun Xu, MSc

Role: CONTACT

0129838798

Facility Contacts

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Kuicheng Li, MOT

Role: primary

8613926144818

Kuicheng Li, MOT

Role: primary

8613926144818

Kuicheng Li, MOT

Role: primary

8613926144818

References

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Xu Z, Chai SC, Chu SY, Li K. Effects of pressure garments of varying designs on upper extremity sensorimotor functions and quality of life after stroke: Study protocol for a multicenter, double-blind, prospective randomized controlled trial. PLoS One. 2025 Jun 23;20(6):e0326680. doi: 10.1371/journal.pone.0326680. eCollection 2025.

Reference Type DERIVED
PMID: 40549786 (View on PubMed)

Other Identifiers

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JEP-2024-582

Identifier Type: -

Identifier Source: org_study_id