Tolerability of an Anesthesia-free Tonometer Tip

NCT ID: NCT06585423

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-17

Study Completion Date

2026-03-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to compare the tolerability and comfort of 4 different prototype anesthesia-free tonometer tips with the standard tonometer tip in conjunction with anesthesia. The best-tolerated prototype anesthesia-free tonometer tip will be identified for further development for home tonometry.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Glaucoma

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Intraocular pressure measurements using 4 different prototype tips. All standard equipment used to perform Goldmann Applanation Tonometry will be used with the only difference being the applanator tip. The 4 prototypes are as follows and are tested in random order:

1. \- Medical grade acrylic tip covered by a sterile commercially available bandage contact lens (Air Optix, Night and Day Contacts, Alcon). The bandage contact lens will be changed between subjects and the underlying acrylic tip sterilized per standard clinical procedure (bleach soak followed by soak and rinse in sterile water).
2. \- Medical grade acrylic tip coated with medical grade silicone of a thickness \< 100 µm. T
3. \- Medical grade acrylic tip coated with medical grade silicone of a thickness \> 100 µm.
4. \- Medical grade acrylic tip coated with medical grade silicone of a thickness \< 100 µm with blur tint. All tips will be sterilized between subjects
5. \- Standard tip in conjunction with a topical anesthetic
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Medical grade acrylic tip covered by a sterile commercially available bandage contact lens

Group Type EXPERIMENTAL

Sterile commercially available bandage contact lens

Intervention Type DIAGNOSTIC_TEST

Medical grade acrylic tip covered by a sterile commercially available bandage contact lens

Medical grade acrylic tip coated with medical grade silicone of a thickness < 100 µm

Group Type EXPERIMENTAL

Medical grade silicone of a thickness <100 µm

Intervention Type DIAGNOSTIC_TEST

Medical grade acrylic tip coated with medical grade silicone of a thickness \<100 µm

Medical grade acrylic tip coated with medical grade silicone of a thickness > 100 µm

Group Type EXPERIMENTAL

Medical grade silicone of a thickness >100 µm

Intervention Type DIAGNOSTIC_TEST

Medical grade acrylic tip coated with medical grade silicone of a thickness \>100 µm

Medical grade acrylic tip coated with medical grade silicone of a thickness < 100 µm with blue tint

Group Type EXPERIMENTAL

Medical grade silicone of a thickness <100 µm with blur tint

Intervention Type DIAGNOSTIC_TEST

Medical grade acrylic tip coated with medical grade silicone of a thickness \<100 µm with blur tint

Standard tip in conjunction with a topical anesthetic

Group Type ACTIVE_COMPARATOR

Standard tip in conjunction with a topical anesthetic

Intervention Type DIAGNOSTIC_TEST

Standard tip in conjunction with a topical anesthetic

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Sterile commercially available bandage contact lens

Medical grade acrylic tip covered by a sterile commercially available bandage contact lens

Intervention Type DIAGNOSTIC_TEST

Medical grade silicone of a thickness <100 µm

Medical grade acrylic tip coated with medical grade silicone of a thickness \<100 µm

Intervention Type DIAGNOSTIC_TEST

Medical grade silicone of a thickness >100 µm

Medical grade acrylic tip coated with medical grade silicone of a thickness \>100 µm

Intervention Type DIAGNOSTIC_TEST

Medical grade silicone of a thickness <100 µm with blur tint

Medical grade acrylic tip coated with medical grade silicone of a thickness \<100 µm with blur tint

Intervention Type DIAGNOSTIC_TEST

Standard tip in conjunction with a topical anesthetic

Standard tip in conjunction with a topical anesthetic

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Presenting for a routine eye exam
* ≥ 18 years of age
* Able and willing to give consent

Exclusion Criteria

* History of corneal scarring
* Active infection of the eye
* History of alternated corneal sensitivity
* History of corneal surgery
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Duke University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Joanne Wen, MD

Role: PRINCIPAL_INVESTIGATOR

Duke Eye Center

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Duke Eye Center

Durham, North Carolina, United States

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

United States

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Joanne Wen, MD

Role: CONTACT

Phone: 1 919 684 2975

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Joanne Wen, MD

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

399000397

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

Pro00115919

Identifier Type: -

Identifier Source: org_study_id