Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

NCT ID: NCT06568367

Last Updated: 2025-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

520 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-01

Study Completion Date

2026-12-31

Brief Summary

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SUSTAIN (Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder) is a Phase 3, multi-center, randomized, double-blind, placebo-controlled, parallel- group trial to assess the efficacy and safety of solriamfetol in adults with excessive sleepiness associated with shift work disorder (SWD).

Detailed Description

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Eligible subjects must meet the International Classification of Sleep Disorders, Third Edition (ICSD-3) criteria for Shift Work Disorder (SWD). Subjects will be randomized in a 1:1:1 ratio to receive solriamfetol titrated to either 150 mg, 300 mg, or placebo once per night shift for 12 weeks.

Conditions

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Excessive Sleepiness Shift-work Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Solriamfetol 150mg

Up to 12 weeks

Group Type EXPERIMENTAL

Solriamfetol 150 mg

Intervention Type DRUG

Solriamfetol tablets, taken once daily

Solriamfetol 300mg

Up to 12 weeks

Group Type EXPERIMENTAL

Solriamfetol 300 mg

Intervention Type DRUG

Solriamfetol tablets, taken once daily

Placebo

Up to 12 weeks

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo tablets, taken once daily

Interventions

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Solriamfetol 150 mg

Solriamfetol tablets, taken once daily

Intervention Type DRUG

Solriamfetol 300 mg

Solriamfetol tablets, taken once daily

Intervention Type DRUG

Placebo

Placebo tablets, taken once daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Meets International Classification of Sleep Disorders, Third Edition (ICSD-3) criteria for Shift Work Disorder (SWD)
* Provides written informed consent to participate in the study before the conduct of any study procedures.
* Male or female, aged 18 to 65 inclusive.

Exclusion Criteria

* Prior exposure to solriamfetol/Sunosi, through either a clinical study or prescription.
* Unable to comply with study procedures.
* Medically inappropriate for study participation in the opinion of the investigator.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Axsome Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Clinical Research Site

Cullman, Alabama, United States

Site Status RECRUITING

Clinical Research Site

Chandler, Arizona, United States

Site Status RECRUITING

Clinical Research Site

Tucson, Arizona, United States

Site Status RECRUITING

Clinical Research Site

Little Rock, Arkansas, United States

Site Status RECRUITING

Clinical Research Site

Cerritos, California, United States

Site Status RECRUITING

Clinical Research Site

Chula Vista, California, United States

Site Status RECRUITING

Clinical Research Site

Huntington Beach, California, United States

Site Status RECRUITING

Clinical Research Site

Long Beach, California, United States

Site Status RECRUITING

Clinical Research Site

Santa Ana, California, United States

Site Status RECRUITING

Clinical Research Site

Colorado Springs, Colorado, United States

Site Status RECRUITING

Clinical Research Site

Brandon, Florida, United States

Site Status RECRUITING

Clinical Research Site

Hialeah, Florida, United States

Site Status RECRUITING

Clinical Research Site

Miami, Florida, United States

Site Status RECRUITING

Clinical Research Site

Miami, Florida, United States

Site Status RECRUITING

Clinical Research Site

Miami, Florida, United States

Site Status RECRUITING

Clinical Research Site

Miami Lakes, Florida, United States

Site Status RECRUITING

Clinical Research Site

Atlanta, Georgia, United States

Site Status RECRUITING

Clinical Research Site

Stockbridge, Georgia, United States

Site Status RECRUITING

Clinical Research Site

Towson, Maryland, United States

Site Status RECRUITING

Clinical Research Site

Boston, Massachusetts, United States

Site Status RECRUITING

Clinical Research Site

Lansing, Michigan, United States

Site Status RECRUITING

Clinical Research Site

Novi, Michigan, United States

Site Status RECRUITING

Clinical Research Site

Southfield, Michigan, United States

Site Status RECRUITING

Clinical Research Site

Chesterfield, Missouri, United States

Site Status RECRUITING

Clinical Research Site

St Louis, Missouri, United States

Site Status RECRUITING

Clinical Research Site

Henderson, Nevada, United States

Site Status RECRUITING

Clinical Research Site

Middletown, New Jersey, United States

Site Status RECRUITING

Clinical Research Site

Denver, North Carolina, United States

Site Status RECRUITING

Clinical Research Site

Fayetteville, North Carolina, United States

Site Status RECRUITING

Clinical Research Site

Huntersville, North Carolina, United States

Site Status RECRUITING

Clinical Research Site

Cincinnati, Ohio, United States

Site Status RECRUITING

Clinical Research Site

Cincinnati, Ohio, United States

Site Status RECRUITING

Clinical Research Site

Wyomissing, Pennsylvania, United States

Site Status RECRUITING

Clinical Research Site

Charleston, South Carolina, United States

Site Status RECRUITING

Clinical Research Site

Columbia, South Carolina, United States

Site Status RECRUITING

Clinical Research Site

Houston, Texas, United States

Site Status RECRUITING

Clinical Research Site

San Antonio, Texas, United States

Site Status RECRUITING

Clinical Research Site

Sugar Land, Texas, United States

Site Status RECRUITING

Clinical Research Site

Markham, Ontario, Canada

Site Status RECRUITING

Clinical Research Site

Toronto, Ontario, Canada

Site Status RECRUITING

Countries

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United States Canada

Central Contacts

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Study Director

Role: CONTACT

212-332-5061

Related Links

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https://www.SustainSWD.com

SUSTAIN Study Website

http://axsome.com

Axsome Therapeutics Website

Other Identifiers

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SOL-SWD-301

Identifier Type: -

Identifier Source: org_study_id

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