Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
66 participants
INTERVENTIONAL
2024-08-20
2026-04-30
Brief Summary
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Hypothesis to be tested: HIIT, performed on a recumbent stepper, will significantly enhance muscle power in chronic stroke survivors when compared with moderate-intensity continuous training (MICT) Design and subjects: Assessor-blinded, stratified, randomised, placebo-controlled clinical trial involving eligible 66 chronic stroke survivors.
Interventions: Participants will be randomly allocated to one of three groups: the HIIT group, the MICT group, or a stretching group (active control). Each group will attend sessions three times per week for 12 consecutive weeks, totaling 36 training sessions.
Main outcome measures: Assessments will be conducted at baseline, at mid-term of the intervention (week 6), at the end of the intervention (week 12), and at a 12-week follow-up (week 24). The primary outcome measure will be muscle power. Secondary outcome measures will include muscle strength, body composition, biomarkers, motor function, balance function, cardiorespiratory response, and psychosocial response.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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High-intensity interval training
The HIIT session will consist of a 3-minute warm-up, a 20-minute main exercise, and a 2-minute cool-down. The main exercise for HIIT will include ten high-intensity intervals, interspersed with ten low-intensity intervals.
High-intensity Interval Training
There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.
Moderate-intensity continuous training
The MICT session will consist of a 3-minute warm-up, a main exercise that is isoenergetic with the HIIT session (lasting approximately 30 minutes), and a 2-minute cool-down. The intensity during the main exercise for MICT will remain constant throughout the session.
Moderate-Intensity Continuous Training
There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.
Stretching
The stretching group will receive 25 minutes of whole-body stretching.
Stretching
There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.
Interventions
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High-intensity Interval Training
There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.
Moderate-Intensity Continuous Training
There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.
Stretching
There will be three sessions per week for 12 consecutive weeks, totaling 36 training sessions.
Eligibility Criteria
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Inclusion Criteria
* 1-5 years following the first-ever stroke confirmed by magnetic resonance imaging or computed tomography
* Able to walk 10 meters independently with or without a walking aid
* Class I or II according to the New York Heart Association Functional Classification (no limitation or slight limitation of physical activity due to symptoms during ordinary physical activity)
Exclusion Criteria
* Undergoing osteoporosis treatments within the past 3 years, use of oral corticosteroids for more than 3 months within the past year, or botulinum toxin injections in the paretic lower limb within the past 6 months
* Participation in ongoing stroke rehabilitation services or structured exercise programme
* Cognitive or communication issues that could limit the ability to follow instructions
* Contraindications to HIIT, graded exercise testing, or failure to pass medical clearance from a specialist
50 Years
80 Years
ALL
No
Sponsors
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The Hong Kong Polytechnic University
OTHER
Responsible Party
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Locations
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The Hong Kong Polytechnic University
Kowloon, , Hong Kong
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HSEARS20230720002
Identifier Type: -
Identifier Source: org_study_id
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