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NLR and Emergency Surgery

NCT ID: NCT06549101

Last Updated: 2024-12-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

851 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-09-23

Study Completion Date

2023-12-30

Brief Summary

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In the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (NLR) is an index that reflects the state of inflammation and oxidative stress. In the perioperative period, NLR has been described as a predictor for patients who will develop renal injury, ischemic stroke, and myocardial injury. Since preoperative inflammation is a predictor of morbidity and mortality in patients undergoing non-cardiac surgery, a retrospective analysis of the inflammatory status of patients undergoing surgery at the center is proposed.

Detailed Description

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A retrospective analysis of patients operated on at the Clinical Hospital of the University of Chile is proposed. The search will be conducted in the electronic medical records of all patients operated on between January and December 2021, with no exclusion criteria for this analysis. Demographic data, complications, length of hospital stay, and specific characteristics such as the need for mechanical ventilation, time spent in intermediate care units, and ICU as well as total hospitalization time will be recorded. For the purpose of this study, the preoperative complete blood count of the patients will be analyzed to search for hematological variables that reflect the state of preoperative systemic inflammation.

Conditions

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Emergency Surgery

Keywords

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Neutrophil-to-lymphocyte ratio Emergency surgery NLR

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Availability of complete blood count in electronic medical records of all patients operated on between January and December 2021

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Chile

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Felipe Maldonado, M.D., M. Sc.

Role: STUDY_CHAIR

Hospital Clínico de la Universidad de Chile

Locations

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Hospital Clínico de la Universidad de Chile

Santiago, Santiago Metropolitan, Chile

Site Status

Countries

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Chile

References

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Maldonado F, Albornoz M, Enriquez I, Espinoza C, Chang H, Carrasco L, Diaz-Papapietro C, Medina F, Gonzalez R, Caceres M. Association of neutrophil-to-lymphocyte ratio with age and 180-day mortality after emergency surgery. BMC Anesthesiol. 2024 Sep 17;24(1):329. doi: 10.1186/s12871-024-02718-z.

Reference Type DERIVED
PMID: 39289610 (View on PubMed)

Other Identifiers

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OAIC 37/22

Identifier Type: -

Identifier Source: org_study_id