Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2024-07-20
2025-11-30
Brief Summary
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Methods: This is a pilot randomized controlled trial that will involve 50 patients with hypertension (HT) who do not meet the current physical activity guidelines defined by the World Health Organization. Participants will be randomly assigned in a 1:1 ratio using stratified and blocked randomization to either the IRE (wall squat) group or stretching exercise (active control) group. A well-structured, widely accepted, and validated 24-week wall squat program (2 minutes per exercise, 2 minutes of rest between sets, and 3 sessions per week) will be implemented, as it has been commonly used in previous research. All patients will be followed up for 24 weeks. Control group will receive exact same treatment except that IRE is replaced by frequency-matched and time-matched stretching exercise. The primary outcome measure will be rate of recruitment. Secondary outcomes will include BP parameters from 24-hour ambulatory BP monitoring
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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isometric exercise
wall squat exercise. Each exercise session will contain 4 sets of 2-minute wall squat isometric holds with 2 minutes of rest between each set (approximately 14 minutes per session in total), and a total of 3 sessions will be arranged every week (with ideally 48 h between exercises)
wall squat
self-learnt wall squat exercise to be conducted for totally 24 weeks
passive stretching
A frequency-matched (3x/week) and time-matched (\~14 minutes each session) passive static stretching exercise will be used
passive stretching
time-matched passive stretching exercise to be conducted for totally 24 weeks
Interventions
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wall squat
self-learnt wall squat exercise to be conducted for totally 24 weeks
passive stretching
time-matched passive stretching exercise to be conducted for totally 24 weeks
Eligibility Criteria
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Inclusion Criteria
* reported no regular physical activity or less than that recommended for adults by the World Health Organization (e.g. \<150 minutes of moderate-intensity aerobic exercise per week);
* on stable doses of anti-HT medication(s) for ≥4 weeks if the patient is receiving drug treatments
* agree for no drug changes during the intervention period (24 weeks);
Exclusion Criteria
* unwillingness to repeat ABPM
* relative contraindications to ABPM (i.e. diagnosed atrial fibrillation, nighttime workers, occupational drivers, or patients with bleeding tendencies)
* severe osteoarthritis pending knee replacement surgery
* known secondary HT
* use of ≥3 anti-HT medications at maximum doses or ≥4 anti-HT medications
* SBP or DBP are \>160 mmHg or \>100 mmHg, respectively, on ABPM
* pregnancy/breastfeeding
* active malignancy
18 Years
ALL
No
Sponsors
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Chinese University of Hong Kong
OTHER
Responsible Party
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Lee Kam Pui
clinical associate professor
Locations
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School of public health and primary care
Hong Kong, , Hong Kong
Countries
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Other Identifiers
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IRE001
Identifier Type: -
Identifier Source: org_study_id