A Study of Participants With Initially Unresectable Hepatocellular Carcinoma That is Treated With Atezolizumab and Bevacizumab Plus Transarterial Chemoembolization
NCT ID: NCT06503250
Last Updated: 2025-03-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
113 participants
OBSERVATIONAL
2024-07-19
2024-11-27
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Retrospective Cohort
Secondary data from medical records of approx 5 sites across China will be utilized. Patient identification period is between 28 Oct 2020 to 31 Dec 2023. The index date is defined as the earlier date of initiating Atezo+Bev or TACE after the initial diagnosis of unresectable HCC. Baseline period is defined as 60 days prior to the index date. Observation period is defined as the period from the index date until death, latest visit record during retrospective observation period, diagnosis of other primary cancer (except basal cell carcinoma), or 31 March 2024, whichever occurs first.
Atezolizumab
Observational Study
Bevacizumab
Observational Study
Transarterial Chemoembolization
Observational Study
Interventions
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Atezolizumab
Observational Study
Bevacizumab
Observational Study
Transarterial Chemoembolization
Observational Study
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. At least one dose of Atezo+Bev and one cycle of TACE spaced no longer than 4 weeks
3. Diagnosed with HCC and considered as unresectable by any of the below criteria:
* Predicted insufficient future liver remnant volume (FLRV) after liver resection, OR
* Predicted unattainable safe negative tumor margin resection, i.e., R0 resection, OR
* "Unresectable" directly documented in the medical records
Exclusion Criteria
2. Treated with other systemic therapy or resection against HCC
3. Diagnosed with concomitant cancer except for basal cell carcinoma
4. Advanced portal vein tumor thrombosis (PVTT) as defined by: Grade Vp 4, Cheng's Classification Type III or IV, or presence of a tumor thrombus in the main trunk of the portal vein, a portal vein branch contralateral to the primarily involved lobe, or superior mesenteric vein
5. China Liver Cancer (CNLC) Stage IIIb, or history of extrahepatic metastasis
6. Terminal-stage HCC
18 Years
ALL
No
Sponsors
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Hoffmann-La Roche
INDUSTRY
Responsible Party
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Locations
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The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, , China
The Third Affiliated Hospital of Sun Yat-Sen University
Guangzhou, , China
Zhongshan Hospital Fudan University
Shanghai, , China
Tianjin First Central Hospital
Tianjin, , China
The First Affiliated Hospital of Xian Jiao Tong University
Xi'an, , China
Countries
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Other Identifiers
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ML45337
Identifier Type: -
Identifier Source: org_study_id
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