Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors
NCT ID: NCT06500377
Last Updated: 2025-07-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
44 participants
INTERVENTIONAL
2024-06-17
2026-06-17
Brief Summary
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Detailed Description
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I. Assess the feasibility to attend and complete the meditation program as scheduled (combined arms) within six weeks.
EXPLORATORY OBJECTIVES:
I. Assess the ability of breathing, mindfulness, focused attention, and a combination of all three meditation techniques to enhance relaxation in cancer survivors.
II. Determine which meditation technique improves the outcome measures the most.
III. Explore which meditation method is preferred by the subjects.
OUTLINE: Patients are randomized to 1 of 4 arms.
ARM I: Patients learn breathing only meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
ARM II: Patients learn focused attention only meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
ARM III: Patients learn mindfulness only meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
ARM IV: Patients learn breathing, focused attention, and mindfulness combined meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Arm I (breathing only meditation)
Patients learn breathing only meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
Biospecimen Collection
Undergo saliva sample collection
Meditation Therapy
Learn breathing only meditation
Questionnaire Administration
Ancillary studies
Arm I (focused attention only meditation)
Patients learn focused attention only meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
Biospecimen Collection
Undergo saliva sample collection
Meditation Therapy
Learn focused attention only meditation
Questionnaire Administration
Ancillary studies
Arm III (mindfulness only meditation)
Patients learn mindfulness only meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
Biospecimen Collection
Undergo saliva sample collection
Meditation Therapy
Learn mindfulness only meditation
Questionnaire Administration
Ancillary studies
Arm IV (combined meditation)
Patients learn breathing, focused attention, and mindfulness combined meditation with an instructor over 60 minutes for 3 sessions within 6 weeks. Patients also practice meditation at home and undergo saliva sample collection on study.
Biospecimen Collection
Undergo saliva sample collection
Meditation Therapy
Learn breathing, focused attention, and mindfulness combined meditation
Questionnaire Administration
Ancillary studies
Interventions
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Biospecimen Collection
Undergo saliva sample collection
Meditation Therapy
Learn breathing only meditation
Meditation Therapy
Learn focused attention only meditation
Meditation Therapy
Learn mindfulness only meditation
Meditation Therapy
Learn breathing, focused attention, and mindfulness combined meditation
Questionnaire Administration
Ancillary studies
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age: ≥ 18 years
* Ability to understand and fluently speak English or Spanish
* No previous training in mind-body relaxation techniques including meditation, yoga, tai chi, qigong, guided imagery, mindfulness-based stress reduction, hypnosis, or cognitive behavior therapy, that exceeds 3 hours. Additionally, no regular practice of mind-body relaxation techniques, or formal experience with mind-body relaxation techniques within the past 12 months
* Visual Analog Scale (VAS) anxiety score of \> 3 from a range from 0 to 10. A "0" means the lowest anxiety score and a "10" means the highest anxiety score
* Long-term cancer survivors who received surgery to treat their cancer ( \> 6 months since last treatment) with no history of chemotherapy, radiation therapy, or other systemic therapy (e.g., hormonal therapy) and/or have completely recovered from surgery OR patients identified as having pre-cancerous lesions that have been surgically treated (e.g., colon polyp that has been removed)
* Willingness to:
* Provide salivary alpha-amylase sample
* Complete stress tests and study questionnaires
* Be monitored with a Bispectral Index (BIS) device
Exclusion Criteria
* Must not have had previous serious illnesses that affect neurological functioning such as strokes, heart attacks, Parkinson disease, etc
* Ongoing active psychiatric condition, depressive/bi-polar related disorders, anxiety, psychosis disorders, or substance use that may interfere with the study including panic disorder, major depression, schizophrenia, and bipolar disease
* Active cancer
* Cancer survivors who have received chemotherapy, radiation therapy, or any other systemic treatment (e.g., hormonal therapy)
* Women who are pregnant
18 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
City of Hope Medical Center
OTHER
Responsible Party
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Principal Investigators
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Richard T Lee
Role: PRINCIPAL_INVESTIGATOR
City of Hope Medical Center
Locations
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City of Hope Medical Center
Duarte, California, United States
City of Hope at Irvine Lennar
Irvine, California, United States
Countries
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Facility Contacts
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Role: backup
Other Identifiers
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NCI-2024-04827
Identifier Type: REGISTRY
Identifier Source: secondary_id
22607
Identifier Type: OTHER
Identifier Source: secondary_id
22607
Identifier Type: -
Identifier Source: org_study_id
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