Liver Function Abnormalities in Patients With Acute Heart Failure
NCT ID: NCT06491628
Last Updated: 2024-07-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
100 participants
OBSERVATIONAL
2024-07-01
2025-08-31
Brief Summary
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Detailed Description
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The pathophysiology of acute heart failure (AHF) is complex and not fully understood. It has been hypothesized that an episode of acute decompensation affects not only the cardiovascular system itself, but may also deteriorate the function of other organs, c ausing serious clinical consequences. Liver involvement has been mostly described and investigated in patients with chronic HF.
Liver enzyme alterations are usually classified as relating predominantly to liver cell necrosis (signified by transaminase elevations) or predominantly to cholestasis (signified by elevated alkaline phosphatase (AP) level).
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Acute decompensated heart failure (de novo or as decompensation of chronic heart failure)
This umbrella term includes patients presenting forthe first time with typical symptoms and signs of heart failure(de novo AHF) and also those with worsening of their pre-existing cardiomyopathy (acute decompensated heart failure).
Avoiding the risk factors
Exercise, Salt and lipid reduction in diet, smoking cessation
Pulmonary edema
It's the real clinical presentation of AHF, typically, signs and symptoms develope rapidly and patients demonstrate severe respiratory distress with tachypnea, orthopnea and pulmonary congestion
Avoiding the risk factors
Exercise, Salt and lipid reduction in diet, smoking cessation
Hypertensive acute heart failure
the condition is associated with elevated blood pressure with accompanying dyspnea. orthopnea and pulmonary congestion, often in patients with relatively preserved left ventricle ejection fraction
Avoiding the risk factors
Exercise, Salt and lipid reduction in diet, smoking cessation
cardiogenic shock
severe peripheral hypoperfusion wih subsequent end organs damage,typically it's associated with low blood pressure and low urine output
Avoiding the risk factors
Exercise, Salt and lipid reduction in diet, smoking cessation
Acute coronary syndrome complicated by heart failure
characterized by complex structural, hemodynamic and neurohormonal interaction need urgent referral for coronary intervention poor outcome
Avoiding the risk factors
Exercise, Salt and lipid reduction in diet, smoking cessation
Interventions
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Avoiding the risk factors
Exercise, Salt and lipid reduction in diet, smoking cessation
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* acute and chronic liver diseases
18 Years
90 Years
ALL
No
Sponsors
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Sohag University
OTHER
Responsible Party
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Sara Mohamed Saber
Liver function abnormalities in patients with acute heart failure in Sohag University Hospitals
Principal Investigators
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Hamdy Saad
Role: STUDY_CHAIR
Sohag University
Haitham Mohammad
Role: STUDY_CHAIR
Sohag University
Locations
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Sohag university
Sohag, , Egypt
Countries
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Central Contacts
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Hassan Ahmed
Role: CONTACT
Other Identifiers
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LFTs abnormalities in AHF
Identifier Type: -
Identifier Source: org_study_id
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