Time-restricted Eating for Postpartum Weight Loss

NCT ID: NCT06491537

Last Updated: 2025-06-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-22

Study Completion Date

2029-02-01

Brief Summary

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This study is being done to assess the feasibility and acceptability of a time-restricted eating intervention among postpartum women with overweight/obesity.

Detailed Description

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Existing postpartum weight retention (PPWR) interventions have had limited success. Timing-based interventions, such as early time-restricted eating (eTRE), show significant improvements in cardiometabolic endpoints in non-postpartum cohorts. The purpose of the Time4Mom study is to conduct a pilot randomized trial of a postpartum-adapted eTRE intervention to test feasibility and acceptability of the eTRE intervention and trial protocol. We will also compare changes in clinical outcomes of interest and patient-reported outcomes between eTRE (intervention) and control groups.

This 2-arm trial will randomize 60 postpartum women to either Control or eTRE for 12 weeks (n=30/group).

Conditions

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Postpartum Weight Retention Overweight and Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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eTRE Intervention

A 9-hour eating/15-hour fasting time-restricted eating (eTRE) intervention with tapered remote behavioral support sessions delivered by a trained interventionist.

Group Type EXPERIMENTAL

Early Time-Restricted Eating (eTRE)

Intervention Type BEHAVIORAL

12 weeks of eTRE intervention. Study staff will provide 7 support sessions with brief behavioral support, including evidence based strategies of problem-solving, action planning, and motivational interviewing.

Control

Control condition in which participants are instructed to maintain their baseline eating window with tapered remote behavioral support check-ins delivered by a trained interventionist to encourage maintenance of the baseline eating window.

Group Type ACTIVE_COMPARATOR

Control

Intervention Type BEHAVIORAL

The control group will be instructed to maintain their average eating window for the 12-week period. Study staff will contact participants 7 times to encourage maintenance.

Interventions

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Early Time-Restricted Eating (eTRE)

12 weeks of eTRE intervention. Study staff will provide 7 support sessions with brief behavioral support, including evidence based strategies of problem-solving, action planning, and motivational interviewing.

Intervention Type BEHAVIORAL

Control

The control group will be instructed to maintain their average eating window for the 12-week period. Study staff will contact participants 7 times to encourage maintenance.

Intervention Type BEHAVIORAL

Other Intervention Names

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Intermittent Fasting Timed Eating

Eligibility Criteria

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Inclusion Criteria

* 18 years of age or older
* Experienced a healthy singleton pregnancy
* 6-16 weeks postpartum at enrollment
* Body mass index ≥25 at enrollment
* Willing to consent

Exclusion Criteria

* Self-reported major health condition (such as renal disease, cancer, or Type 1 or Type 2 diabetes)
* Current treatment for severe psychiatric disorder (such as schizophrenia)
* Self-reported diagnosis of anorexia or bulimia
* Current use of medication expected to significantly impact body weight
* Current substance abuse
* Participation in another dietary and/or weight management intervention postpartum
* Performing overnight shiftwork \>1x/week
* Regularly fasting ≥14 hr/day or completing twelve or more 24-hr fasts within the past year
* Unable to understand and communicate in English
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

Sponsor Role collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Camille S Worthington, PhD

Primary Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Camille Worthington, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Camille S Worthington, PhD

Role: CONTACT

205.975.7274

Facility Contacts

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Camille S Worthington, PhD

Role: primary

205-975-7274

Other Identifiers

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K23HD108345

Identifier Type: NIH

Identifier Source: secondary_id

View Link

IRB-300012535

Identifier Type: -

Identifier Source: org_study_id

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