An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors

NCT ID: NCT06487624

Last Updated: 2025-04-08

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-04-02
• Study Completion Date: 2026-08-31

Brief Summary

The purpose of this study is to find out whether IV injection of HCB301 is an effective treatment for different types of advanced solid tumors and relapsed and refractory classical Hodgkin lymphomas and what side effects (unwanted effects) may occur in subjects aged 18 years old and above.

Detailed Description

This is a phase 1, open-label, multicenter, dose-escalation study. This study is to evaluate the safety, tolerability, pharmacokinetics (PK), preliminary efficacy, and identification of maximum tolerated dose (MTD) of HCB301 intravenous injection in adults with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Eligible subjects must have failed standard therapies, been intolerable, or been considered medically inappropriate by the investigator. Subjects will be treated until unacceptable AEs, radiographic or clinical documented disease progression, withdrawal of consent, loss to follow-up, death, or termination of the study, whichever occurs first.

Conditions

Advanced Solid Tumor; Refractory Hodgkin Lymphoma

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Experimental: 0.3 mg/kg HCB301

0.3 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Experimental: 0.6 mg/kg HCB301

0.6 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Experimental: 1.2 mg/kg HCB301

1.2 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Experimental: 2.4 mg/kg HCB301

2.4 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Experimental: 4.8 mg/kg HCB301

4.8 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Experimental: 9.6 mg/kg HCB301

9.6 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Experimental: 15.0 mg/kg HCB301

15.0 mg/kg HCB301 in subjects with advanced solid tumors or relapsed and refractory classical Hodgkin lymphomas.

Group Type: EXPERIMENTAL

HCB301

Intervention Type: DRUG

HCB301 administered via. intravenous (IV) infusion.

Interventions

HCB301

HCB301 administered via. intravenous (IV) infusion.

Intervention Type: DRUG

Other Intervention Names

2023-3979 Solid Tumors

Eligibility Criteria

Inclusion Criteria

1. Able to understand and be willing to sign the ICF.

2. Male and female subjects of ≥18 years of age.

3. Histologically/cytologically confirmed, locally advanced solid tumor:

subjects confirmed advanced solid tumors who have relapsed or refractory and should have no options for standard or approved therapies known to potentially confer clinical benefit or classical Hodgkin lymphoma, relapsed or refractory to at least 2 prior lines of systemic therapy.

4. For subjects with advanced solid tumors - must have at least 1 measurable lesion as defined by Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 at baseline.

5. For subjects with classical Hodgkin lymphoma - must have classical Hodgkin lymphoma that is measurable or assessable for response.

6. Must have ECOG performance status of 0 to 1 at Screening.

7. Able to provide tumor tissue samples.

8. Have a life expectancy of ≥12 weeks.

Exclusion Criteria

1. With known history of hypersensitivity to any components of HCB301.

2. Known active or untreated CNS metastases and/or carcinomatous meningitis.

3. Have undergone a major surgery or radical radiotherapy within 28 days or palliative radiotherapy within 14 days or have used a radioactive drug within 56 days prior to the first dose of HCB301.

4. Clinically significant cardiovascular condition.

5. Any previous treatment-related toxicities which have not recovered to ≤ Grade 1 as evaluated by National Cancer Institute, Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0 or baseline, except alopecia and anemia.

6. With known inherited or acquired bleeding disorder or bleeding diathesis. .

7. Have RBC transfusion within 4 weeks prior to Screening.

8. With a previously documented diagnosis of hemolytic anemia or Evans Syndrome in the last 3 months.

9. Any investigational or approved systemic cancer therapy administered within 21 days or 5 half-lives, whichever is shorter, before the first dose of the study drug.

10. Active use of vitamin K antagonist anticoagulant like warfarin. Use of low molecular weight heparin and factor Xa inhibitors will be permitted on case by case basis. There will be no restriction for daily aspirin ≤ 100 mg/QD.

11. Have used herbal medication within 14 days prior to the first dose of HCB301.

12. Have received any treatment targeting the SIRPα-CD47, PD-L1, or TGF-β pathway.

13. Have other malignancies requiring treatment within 2 years prior to the first dose of HCB301.

14. An investigational device used within 28 days prior to the first dose of HCB301.

15. Positive for hepatitis B, active hepatitis C infections, positive for HIV, or known active or latent tuberculosis.

16. Known to have a history of alcoholism or drug abuse.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

FBD Biologics Limited

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Prisma Health-Upstate

Greenville, South Carolina, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

FBD Clinical

Role: CONTACT

HCB301-101@hanchorbio.com

+886-2-27921366

Other Identifiers

HCB301-101

Identifier Type: -

Identifier Source: org_study_id