Cerebral Blood Flow: Helmet vs Oronasal Mask During Continuous Positive Airway Pressure Ventilation
NCT ID: NCT06480253
Last Updated: 2024-06-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
19 participants
INTERVENTIONAL
2024-07-01
2024-07-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Helmet
Partecipants will be started on Continuous Positive Airway Pressure using the Helmet interface
Helmet Continuous Positive Airway Pressure
Partecipants will be started on Continuous Positive Airway Pressure at 10 cmH2O on inspired fraction of oxygen (FiO2)= 21% with the Helmet interface for a duration of 5 minutes while laying down on a stretcher with head elevated at 60°
Oronasal Mask
Partecipants will be started on Continuous Positive Airway Pressure using the oronasal mask interface
Oronasal Mask Continuous Positive Airway Pressure
Partecipants will be started on Continuous Positive Airway Pressure at 10 cmH2O on Inspired fraction of oxygen (FiO2)= 21% with the oronasal mask interface for a duration of 5 minutes while laying down on a stretcher with head elevated at 60°
Interventions
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Helmet Continuous Positive Airway Pressure
Partecipants will be started on Continuous Positive Airway Pressure at 10 cmH2O on inspired fraction of oxygen (FiO2)= 21% with the Helmet interface for a duration of 5 minutes while laying down on a stretcher with head elevated at 60°
Oronasal Mask Continuous Positive Airway Pressure
Partecipants will be started on Continuous Positive Airway Pressure at 10 cmH2O on Inspired fraction of oxygen (FiO2)= 21% with the oronasal mask interface for a duration of 5 minutes while laying down on a stretcher with head elevated at 60°
Eligibility Criteria
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Inclusion Criteria
* Ability to give informed consent
Exclusion Criteria
* known pulmonary pathologies
* known vascular pathologies
* history of concussion
* history of headache
18 Years
ALL
Yes
Sponsors
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Papa Giovanni XXIII Hospital
OTHER
Responsible Party
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Roberto Cosentini
Director of Emergency Department
Principal Investigators
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Roberto Cosentini, MD
Role: STUDY_DIRECTOR
Ospedale Papa Giovanni XXIII
Locations
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Ospedale Papa Giovanni XXIII
Bergamo, , Italy
Countries
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Central Contacts
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Facility Contacts
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Roberto Cosentini, MD
Role: primary
References
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Haring HP, Hormann C, Schalow S, Benzer A. Continuous positive airway pressure breathing increases cerebral blood flow velocity in humans. Anesth Analg. 1994 Nov;79(5):883-5. doi: 10.1213/00000539-199411000-00011.
Scala R, Turkington PM, Wanklyn P, Bamford J, Elliott MW. Effects of incremental levels of continuous positive airway pressure on cerebral blood flow velocity in healthy adult humans. Clin Sci (Lond). 2003 Jun;104(6):633-9. doi: 10.1042/CS20020305.
Kolbitsch C, Lorenz IH, Hormann C, Schocke M, Kremser C, Zschiegner F, Felber S, Benzer A. The impact of increased mean airway pressure on contrast-enhanced MRI measurement of regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV), regional mean transit time (rMTT), and regional cerebrovascular resistance (rCVR) in human volunteers. Hum Brain Mapp. 2000 Nov;11(3):214-22. doi: 10.1002/1097-0193(200011)11:3<214::AID-HBM70>3.0.CO;2-I.
Yiallourou TI, Odier C, Heinzer R, Hirt L, Martin BA, Stergiopulos N, Haba-Rubio J. The effect of continuous positive airway pressure on total cerebral blood flow in healthy awake volunteers. Sleep Breath. 2013 Mar;17(1):289-96. doi: 10.1007/s11325-012-0688-0. Epub 2012 Mar 22.
Other Identifiers
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CBF - Helmet vs Mask
Identifier Type: -
Identifier Source: org_study_id