Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated Radiation ThErapy and TEmozolomide in Newly Diagnosed GLioblastoma (GBM) Patients

NCT ID: NCT06477939

Last Updated: 2024-06-27

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 554 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-01
• Study Completion Date: 2032-12-31

Brief Summary

This is phase III randomized, multicenter study adding or not intra-venous Liposomal Trasncrocetin (L-TC) to hypofractionated radiotherapy and concomitant Temozolomide followed by adjuvant Temozolomide in patients with histologically confirmed diagnosis of glioblastoma (GBM).

Detailed Description

During this trial the L-TC will be administered with the hypofractionated chemoradiation treatment to two cohorts:

• Cohort 1 - Non-operable population defined as patients with age less than 70-year-old and with biopsy alone, Karnofski index we propose to use the L-TC with the hypofractionated chemoradiation treatment to two cohorts:
• Cohort 2 - Elderly population defined as patients aged of more than 70-year-old and with Balducci score 1 or with low Balducci score 2 with Karnofski index ≥ 70% but whatever the quality of the surgery. For patients classified with a score of Balducci II, the geriatric assessment is essential. Although we are aware of the heterogeneity of patients in this group, we hope that the geriatric assessment will make it possible to reduce this heterogeneity by including only patients with a Charlson score <4 and a score of autonomy IADL = 4

The eligible population will be randomized this combination with the treatment reference according to Perry et al publication

Conditions

Glioblastoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Radiotherapy plus Temozolomide

Group Type: ACTIVE_COMPARATOR

Administration of L-TC

Intervention Type: DRUG

Administration of L-TC (300 mg) as an IV perfusion, before each radiotion session

Radiotherapy : delivered at 40.5 Gy in 15 fractions of 2.7 Gy - One fraction a day 5 fractions per week

+ Temozolomide delivered at a dose of 75 mg per square meter per day, given 7 days per week from the first day of radiotherapy until the last day of radiotherapy, but for no longer than 25 days.

Administration of L-TC on top of Radiotherapy plus Temozolomide

Group Type: EXPERIMENTAL

Radiotherapy plus Temozolomide

Intervention Type: OTHER

Radiotherapy : delivered at 40.5 Gy in 15 fractions of 2.7 Gy - One fraction a day 5 fractions per week

+ Temozolomide delivered at a dose of 75 mg per square meter per day, given 7 days per week from the first day of radiotherapy until the last day of radiotherapy, but for no longer than 25 days.

Interventions

Administration of L-TC

Administration of L-TC (300 mg) as an IV perfusion, before each radiotion session

Radiotherapy : delivered at 40.5 Gy in 15 fractions of 2.7 Gy - One fraction a day 5 fractions per week

+ Temozolomide delivered at a dose of 75 mg per square meter per day, given 7 days per week from the first day of radiotherapy until the last day of radiotherapy, but for no longer than 25 days.

Intervention Type: DRUG

Radiotherapy plus Temozolomide

Radiotherapy : delivered at 40.5 Gy in 15 fractions of 2.7 Gy - One fraction a day 5 fractions per week

+ Temozolomide delivered at a dose of 75 mg per square meter per day, given 7 days per week from the first day of radiotherapy until the last day of radiotherapy, but for no longer than 25 days.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Cohort 1 - Non-operable patients

• Patients aged at least 18 years old and ≤ 70 years old; male or female.
• AND available biopsy
• AND Karnofsky index ≥ 50% at Screening
• Cohort 2 - Elderly patients

• Patients aged > 70 years old; male or female
• AND Balducci score I or II. For patients classified in Balducci II, only light Balducci II will be included, as defined by a Charlson score <4 and a score of autonomy IADL = 4. In the oncogeriatric evaluation, symptoms related to brain cancer disease have not to be considered for this criterion.
• Karnofsky score (KPS) of ≥ 70% at Screening
• Regardless resection
• MRI at maximum 48h00 after surgery if partial, subtotal or macroscopically complete or supra-total resection
• For both cohorts

• Histologically confirmed diagnosis of glioblastoma (GBM) (2016 OMS classification) (Louis et al., 2016).
• Contrast enhancing disease on MRI within 14 days prior to screening.
• Within 2 weeks of baseline visit, hematologic and renal functions as specified: Absolute neutrophil count ≥ 1500/mm3, platelets ≥ 100,000/mm3, Hgb ≥ 9.0g/dL, creatinine ≤ 1.7mg/dl, total bilirubin ≤ 1.5mg/dL, blood urea nitrogen (BUN) within 2 times the upper limit of normal, transaminases ≤ 4 times above the upper limits of the institutional norm.
• Sexually active patients must use an acceptable method of contraception while receiving doses of study medication.
• Females of childbearing potential must have a negative serum or urine pregnancy test at screening and have additional pregnancy tests during study.

Exclusion Criteria

• For both cohorts

• Any previous radiotherapy (RT) of the brain whatever the interval between previous brain RT and diagnoses of GBM)
• Any previous treatment of the GBM (except surgery) such as chemotherapy (including Gliadel wafer or gliasite application), immunotherapy, therapy with a biologic agent, hormonal therapy or Carmustine implant for brain tumors or immunotherapy, including vaccination (whatever the interval between previous treatment and diagnoses of GBM). Glucocorticoid therapy is allowed.
• Previous digestive disease with mis-absorption such as Crohn disease or chronic colitis
• Ongoing diarrhea grade ≥ 2 in the NCI CTCAE V5.0 (whatever the cause)
• Inclusion in another trial in the 30 previous days
• Patient who cannot undergo MRI
• Pregnant or lactating woman.
• Serious concurrent infection or medical illness that would jeopardize the ability of the patient to receive study treatment with reasonable safety.
• Patients with previous cancer (< 5 years) except basocellular skin tumors and in situ cervix tumor
• Patient has a known hypersensitivity to crocetins, L-TC or any of its excipients.
• Contraindication of temozolomide as described in the Summary of product characteristics.
• Patient who cannot understand French language.
• Patient without French National Health insurance
• Patient who cannot be reliable for follow-up
• Patient under law protection

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

LEAF4Life, Inc.

INDUSTRY

Sponsor Role: collaborator

Institut de cancérologie Strasbourg Europe

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Georges NOEL, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Institut de cancérologie Strasbourg Europe

Locations

Institut de cancérologie Strasbourg Europe

Strasbourg, , France

Countries

France

Central Contacts

Manon VOEGELIN

Role: CONTACT

promotion-rc@icans.eu

368767360 ext. +33

Facility Contacts

Manon VOEGELIN

Role: primary

promotion-rc@icans.eu

368339523 ext. +33

Other Identifiers

2024-515666-13-00

Identifier Type: CTIS

Identifier Source: secondary_id

2020-008

Identifier Type: -

Identifier Source: org_study_id