Effects of Smoking on Placenta and Lactation

NCT ID: NCT06456645

Last Updated: 2024-06-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-01

Study Completion Date

2019-11-05

Brief Summary

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Maternal smoking during pregnancy although it is known to be associated with fetal growth restriction, it's effect on postpartum breastfeeding is not yet clear. The aim of the present study was to examine the impacts of smoking in pregnancy on breastfeeding as well as its impacts on placental immunoreactivity.

Detailed Description

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The study was conducted on 70 women who gave birth via spontaneous vaginal delivery. Groups were classified as Smokers (n=35) and Non-smokers (n=35). The breastfeeding conditions of both groups were evaluated prior to discharge and after postpartum 10th day.

Cross-sections were taken from the placenta tissues after which their IGF-1 (insulin like growth factor-1), Leptin, HPL (human placental lactogen) immunoreactivities were examined.

Conditions

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Smoking, Tobacco Placenta Diseases Breastfeeding Fetal Conditions

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Group 1:

Smokers (study group)

No interventions assigned to this group

Group 2:

Non-Smokers (control group)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Pregnant women who have started smoking at least 100 cigarettes in her lifetime and who now smokes every day,
* Pregnant women who have never smoked throughout their life, including pregnancy(16),
* Pregnant women who gave birth at term,
* Multiple pregnancy, preeclampsia, gestational diabetes, thyroid dysfunction, those who do not have a systemic disease and due to systemic disease during pregnancy those who do not use
* Pregnant women who had spontaneous vaginal delivery,
* In order not to encounter communication barriers and because cultural differences may vary, the pregnant woman is not a foreign national,
* Pregnant women who do not have any barriers to communication by phone,
* Those who do not have any health problems that prevent breastfeeding

Exclusion Criteria

* multiple pregnancy
* insulin dependent diabetes
* pregnant women who have had a cesarean section
* preeclampsia
* thyroid disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Celal Bayar University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Manisa Celal Bayar Universitesi

Manisa, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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MCBU_Smoking

Identifier Type: -

Identifier Source: org_study_id

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