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Tailored Versus Traditional Resistance Exercise

NCT ID: NCT06449716

Last Updated: 2025-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-05-20

Study Completion Date

2025-12-04

Brief Summary

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Preserving functional ability is crucial for healthy aging. Unfortunately, age-related decreases in muscle power often lead to declines in functional ability. As power is the product of force and velocity, decreases in power can originate from changes in muscle force, contraction velocity, or both, varying between individuals. The primary method to prevent functional disability is power-based resistance training. Although training interventions are effective for most older adults, they do not induce substantial improvements in a subset of the population. These inconsistent outcomes may arise from neglecting the observed differences in the force-velocity (F-v) profiles between individuals. Therefore, this study provides a novel approach to resistance exercise, in which exercise dose is tailored according to the individual's F-v profile. The effectiveness of the tailored method will be assessed in a randomized control trial, comparing the effects of an individualized and a non-individualized 12-week training intervention on muscle power parameters and functional ability.

Detailed Description

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Conditions

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Exercise Training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Individualized resistance exercise program

Individualized exercise dose. Individuals with a velocity deficit only perform low-load exercises. Individuals with a force deficit only perform high-load exercises.

Group Type EXPERIMENTAL

12-week progressive power-oriented resistance exercise program

Intervention Type OTHER

2x/week, 35-45 min sessions, on leg press machine

Non-individualized resistance exercise program

Non-individualized exercise dose. All individuals perform a combination of low-load and high-load resistance exercises, regardless of their deficit.

Group Type ACTIVE_COMPARATOR

12-week progressive power-oriented resistance exercise program

Intervention Type OTHER

2x/week, 35-45 min sessions, on leg press machine

Interventions

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12-week progressive power-oriented resistance exercise program

2x/week, 35-45 min sessions, on leg press machine

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Community-dwelling adults
* 65-80 years old

Exclusion Criteria

* Systematic engagement in resistance exercise during the past year
* Unstable cardiovascular disease, neuromuscular disease, acute infection or fever
* Recent surgery
* Lower-extremity injuries
* Low levels of functional ability (i.e., SPPB score ≤ 9)
* Cognitive malfunctioning (i.e., Mini-Mental State Examination \< 24)
Minimum Eligible Age

65 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Universitaire Ziekenhuizen KU Leuven

OTHER

Sponsor Role lead

Responsible Party

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Christophe Delecluse

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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KU Leuven - Department of Movement Sciences

Leuven, Vlaams-Brabant, Belgium

Site Status

Countries

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Belgium

Other Identifiers

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S68434

Identifier Type: -

Identifier Source: org_study_id