Effect of Micronutrient Supplementation on Nerve Conduction Velocity in T1D- RCT

NCT ID: NCT06443593

Last Updated: 2024-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-02-08

Study Completion Date

2025-02-08

Brief Summary

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Type 1 diabetes can complicate to peripheral neuropathy due to preferential involvement of small unmyelinated nerve fibers (pain and temperature sensation) followed by myelinated nerve fibers (vibration and proprioception). The SEARCH for diabetes in youth study found diabetic neuropathy in 7% of T1D youth. The clinical form of peripheral neuropathy is rare in childhood and pathophysiological changes begin during childhood and accelerate in puberty. Adolescents with these changes can be picked up more reliably by electrophysiological studies than by clinical examination. Nerve conduction studies are the gold standard diagnostic tests for detection of peripheral neuropathy. Role of vitamin B12 in nerve regeneration is well known while causal association of vitamin D deficiency in type 1 diabetes and its role in axonal degeneration is also reported. The previous ongoing studies from authors' group have shown relationship between poor oral iron intake and subclinical neuropathy in children with type 1 diabetes (manuscript in submission). The present randomised clinical trial is aimed at assessing vitamin B12, vitamin D and iron supplementation for improvement of nerve conduction velocities in children and youth with type 1 diabetes.

Detailed Description

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Conditions

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Type 1 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Arm 1: Only vitamin B12 supplements

Only vitamin B12 supplements 2.2 mcg OD for 24 weeks

Group Type ACTIVE_COMPARATOR

Tablet VitaBliss vitamin B12 (2.2 mcg)

Intervention Type DIETARY_SUPPLEMENT

Oral vitamin B12 supplement 2.2 mcg from BLISS WELNESS, Bliss Lifesciences, LLP to be administered once daily for 24 weeks

Arm 2: Vitamin B12 and oral iron supplements

Vitamin B12 2.2 mcg OD daily and oral iron 25 mg OD daily for 24 weeks

Group Type ACTIVE_COMPARATOR

Tablet VitaBliss vitamin B12 (2.2 mcg) and Syrup Orofer (5 ml = 50 mg)

Intervention Type DIETARY_SUPPLEMENT

Oral vitamin B12 supplement 2.2 mcg from BLISS WELNESS, Bliss Lifesciences, LLP to be administered once daily for 24 weeks and oral iron 25 mg from Emcure Pharmaceuticals Ltd. to be administered once daily for 24 weeks

Arm 3: Vitamin B12 and vitamin D3

Vitamin B12 2.2 mcg OD daily and vit D3 60,000 IU once in three months for 24 weeks

Group Type ACTIVE_COMPARATOR

Tablet VitaBliss vitamin B12 (2.2 mcg) and Tablet Tayo (60000 IU)

Intervention Type DIETARY_SUPPLEMENT

Oral vitamin B12 supplement 2.2 mcg from BLISS WELNESS, Bliss Lifesciences, LLP to be administered once daily for 24 weeks and oral vitamin D3 (60000 IU) from Eris Lifesciences Ltd to be administered once in 3 months for 24 weeks

Interventions

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Tablet VitaBliss vitamin B12 (2.2 mcg)

Oral vitamin B12 supplement 2.2 mcg from BLISS WELNESS, Bliss Lifesciences, LLP to be administered once daily for 24 weeks

Intervention Type DIETARY_SUPPLEMENT

Tablet VitaBliss vitamin B12 (2.2 mcg) and Syrup Orofer (5 ml = 50 mg)

Oral vitamin B12 supplement 2.2 mcg from BLISS WELNESS, Bliss Lifesciences, LLP to be administered once daily for 24 weeks and oral iron 25 mg from Emcure Pharmaceuticals Ltd. to be administered once daily for 24 weeks

Intervention Type DIETARY_SUPPLEMENT

Tablet VitaBliss vitamin B12 (2.2 mcg) and Tablet Tayo (60000 IU)

Oral vitamin B12 supplement 2.2 mcg from BLISS WELNESS, Bliss Lifesciences, LLP to be administered once daily for 24 weeks and oral vitamin D3 (60000 IU) from Eris Lifesciences Ltd to be administered once in 3 months for 24 weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

1. Children/ parents/ youth willing to participate in the study with an informed consent/ assent.
2. Children/ youth Age \> 10 years
3. Diabetes duration \> 2 years
4. Diagnosed with type 1 diabetes

Exclusion Criteria

1. Age \< 10 years
2. Diabetes duration \< 2 years
3. Children/ youth receiving vitamin B12, vitamin D and/or oral iron supplements
4. Children/ youth with any other disease condition involving nerve or muscle function
5. Children/ parents/ youth not willing to consent to participate in the study.
Minimum Eligible Age

10 Years

Maximum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hirabai Cowasji Jehangir Medical Research Institute

OTHER

Sponsor Role lead

Responsible Party

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Dr. Anuradha Khadilkar

Consultant Pediatrician and Deputy Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Hirabai Cowasji Jehangir Medical Research Institute

Pune, Maharashtra, India

Site Status RECRUITING

Countries

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India

Central Contacts

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Anuradha Khadilkar, MBBS MD DCH

Role: CONTACT

+910206057004

Facility Contacts

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Anuradha V. Khadilkar, MBBS,MD,DCH

Role: primary

+910206057004

Other Identifiers

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JCDC/BHR/24/014

Identifier Type: -

Identifier Source: org_study_id

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