Influenza a (H7N9) Vaccine Delivered Intradermally by High-density Microarray Patch (HD-MAP)
NCT ID: NCT06417853
Last Updated: 2025-03-20
Study Results
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Basic Information
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ACTIVE_NOT_RECRUITING
PHASE1
267 participants
INTERVENTIONAL
2024-07-31
2026-05-31
Brief Summary
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Detailed Description
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The primary objective of the study is to evaluate the safety and tolerability of two doses of H7N9 Influenza A vaccine (12 to 25 mcg HA) with and without QS21 adjuvant (3.3 to 8 mcg), administered by the microarray patch delivery system, compared to IM H7N9 vaccine (7.5 mcg HA) with and without MF59® and uncoated, vaccine-free microarray patch delivery system, administered 21 days apart.
The secondary objectives of the study are to evaluate the immune response to two doses H7N9 Influenza A vaccine (12 to 25 mcg HA) with and without QS21 adjuvant (3.3 to 8 mcg), administered by the microarray patch delivery system, compared to IM H7N9 vaccine (7.5 mcg HA) with and without MF59® and uncoated, vaccine-free microarray patch delivery system, administered 21 days apart.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
DOUBLE
Study Groups
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Arm 1: Influenza A (H7N9) Vaccine Intramuscular Injection
7.5 mcg HA unadjuvanted IM injection (n=30)
No interventions assigned to this group
Arm 2: Unadjuvanted Influenza A (H7N9) Vaccine Microarray Patch
VXS-1219 12 mcg HA (n=30) and VXS-1219U (n =3)
Unadjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA)
12 mcg Influenza A (H7N9) Microarray Patch Delivery System (VXS-1219)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Arm 3: Adjuvanted Influenza A (H7N9) Vaccine Microarray Patch
VXS-1219 25 mcg HA (n=30) and VXS-1219U (n =3)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA)
25 mcg Influenza A (H7N9) Microarray Patch Delivery System (VXS-1219)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Arm 4: Adjuvanted Influenza A (H7N9) Vaccine Intramuscular Injection
7.5 mcg HA with MF59® adjuvant 7.5 IM injection (n=30)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Injection
7.5 mcg Influenza A (H7N9) with MF59® Injection
Arm 5: Adjuvanted Influenza A (H7N9) Vaccine Microarray Patch
VXS-1219A 12 mcg HA + QS21 4 mcg (n=30) and VXS-1219U (n =3)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA, low dose adjuvant)
12 mcg Influenza A (H7N9) with 4 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Arm 6: Adjuvanted Influenza A (H7N9) Vaccine Microarray Patch
VXS-1219A 12 mcg HA + QS21 8 mcg (n=30) and VXS-1219 (n = 3)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA, high dose adjuvant)
12 mcg Influenza A (H7N9) with 8 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Arm 7: Adjuvanted Influenza A (H7N9) Vaccine Microarray Patch
VXS-1219A 20 mcg HA + QS21 3.3 mcg (n=30) and VXS-1219U (n=3)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA, low dose adjuvant)
20 mcg Influenza A (H7N9) with 3.3 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Arm 8: Adjuvanted Influenza A (H7N9) Vaccine Microarray Patch
VXS-1219A 20 mcg HA + QS21 6.7 mcg (n=30) and VXS 1219U (n=3)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA, high dose adjuvant)
20 mcg Influenza A (H7N9) with 6.7 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Interventions
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Unadjuvanted Influenza A (H7N9) Monovalent Vaccine Injection
7.5 mcg Influenza A (H7N9) Injection
Unadjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA)
12 mcg Influenza A (H7N9) Microarray Patch Delivery System (VXS-1219)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA)
25 mcg Influenza A (H7N9) Microarray Patch Delivery System (VXS-1219)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Injection
7.5 mcg Influenza A (H7N9) with MF59® Injection
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA, low dose adjuvant)
12 mcg Influenza A (H7N9) with 4 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (low dose HA, high dose adjuvant)
12 mcg Influenza A (H7N9) with 8 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA, low dose adjuvant)
20 mcg Influenza A (H7N9) with 3.3 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Adjuvanted Influenza A (H7N9) Monovalent Vaccine Microarray Patch Delivery System (high dose HA, high dose adjuvant)
20 mcg Influenza A (H7N9) with 6.7 mcg QS21 Microarray Patch Delivery System (VXS-1219A)
Microarray Patch Delivery System
Vaccine free Microarray Patch Delivery System (VXS-1219U)
Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) within the range 18.0 to 32.0 kg/m² (inclusive) at Screening;
* Being in good health, as determined by satisfactory physical examination, vital signs, 12-lead ECG, laboratory evaluation, stable medical history and clinical judgment of the Investigator. Participants with stable, chronic underlying illnesses such as psychiatric/psychological disorders, hypertension, diabetes, ischemic heart disease or hypothyroidism (or other conditions as per investigator's discretion) may be enrolled at the discretion of the PI and provided their signs and symptoms are controlled. If on regular prescription medication, the medication dose must have been stable for at least three months prior to Screening;
* Adequate venous access in left or right arm to allow collection of small-volume blood samples at different visits;
* Participants of childbearing potential must return a negative pregnancy test at Screening (serum) and pre-dose on Day 1 (urine), and must agree to remain sexually abstinent, use medically effective contraception or have a partner who is sterile or same-sex, from Screening through to Day 78. The use of medically effective contraception or IUD must be stable for at least three months prior to Screening. Surgical sterilisation, e.g., tubal ligation, hysterectomy and bilateral oophorectomy in women, or vasectomy in men, is required at least six months prior to Screening. Post menopausal participants can be included, and are defined as those with at least 12 months since their last menstrual period;
* Non-surgically sterilised, sexually active male participants with a female partner of child-bearing potential must agree to use condoms, together with medically effective contraception for their female partner through to Day 78;
* Participant is able to communicate effectively with study personnel and is considered likely to be reliable, willing and cooperative in terms of compliance with the protocol requirements;
* Participant is able and willing to provide written, personally signed, informed consent to participate in the study
Exclusion Criteria
* Planned administration of any registered vaccine prior to the immunogenicity blood draw on Day 43;
* Previous administration of any H7 vaccine, previous physician-confirmed H7 disease, previous known or potential exposure to avian influenza virus H7N9 HA antigen or any other avian influenza including H5N1, at any time in the past;
* Participant with known chronic spontaneous urticaria or dermographism;
* Known predisposition to keloid-scar formation (participants who have developed a scar caused by BCG vaccine can be included in the study);
* Known anaphylactic hypersensitivity to haemagglutinin or to any of the vaccine or adjuvant excipients (squalene, polysorbate 80, sorbitan trioleate, sodium citrate dihydrate, citric acid monohydrate, protein other than H7N9 including Madin Darby Canine Kidney (MDCK) cell protein, (residual), MDCK cell DNA, (residual), cetyltrimethylammonium bromide (residual), beta-propiolactone (residual), QS21 extract, or any other excipient contained in the study products;
* Allergy to a previous vaccination at any time in the past;
* Known history of demyelinating disease or Guillain-Barré syndrome;
* History of granulomatous diseases, including sarcoidosis and granuloma annulare;
* History of convulsions, epilepsy, other physician diagnosed central nervous system diseases, excluding febrile convulsions experienced as a child that are considered resolved;
* History of clinically significant haematological, gastrointestinal, hepatic, renal, cardiovascular, dermatological, immunological, respiratory, endocrine, oncological, neurological, metabolic, psychiatric disease, that, at the discretion of the Investigator, precludes the participant from the study;
* Presence of active viral or bacterial infection, with or without fever (tympanic temperature ≥38.0 °C), at Day 1 or within 72 hours prior to study vaccination, if determined by the Investigator to be of clinical significance. Participants with a minor illness such as mild diarrhoea or mild upper respiratory infection without fever may be enrolled at the discretion of the Investigator. Enrolment may be deferred for up to one week provided participant remains otherwise eligible and the total Screening period does not exceed 14 days;
* History of any haematological malignancy or active neoplastic disease (Non-melanoma skin cancer that was successfully treated within the 5 year period can be included in the study). Active is defined as having received treatment within the five years prior to Screening;
* Presence of an active medical condition, defined as a condition under current evaluation or treatment, that is considered clinically significant by the Investigator, or a recent illness that is considered clinically significant by the Investigator;
* Any condition that, in the opinion of the Investigator, is considered clinically significant or might interfere with the evaluation of the study objectives;
* Planned surgery requiring a general anaesthetic, or surgery requiring inpatient hospitalisation for at least 24 hours from Screening through to Day 78;
* History of illness and/or infection with Hepatitis B, or Hepatitis C or Human Immunodeficiency Virus (HIV), or a positive test for Hepatitis B surface antigen, Hepatitis C or antibodies against HIV at Screening;
* History of abnormal bleeding, and/or thrombophlebitis unrelated to venepuncture or intravenous cannulation;
* History of autoimmune or autoinflammatory immune-mediated medical conditions;
* Receiving chronic treatment with immunosuppressive therapy, including chronic use (more than 14 continuous days) of corticosteroids within 30 days prior to Day 1.
* Participant who has received immunoglobulins and/or any blood or blood products within three months prior to Day 1 or plans to receive any blood or blood products at any time during the study;
* Participant who has donated blood or plasma, or has had clinically significant blood loss, within 14 days prior to Day 1. Participants who plan to donate blood or plasma within 12 weeks of dose 2 should also be excluded;
* Female participant who is pregnant or breast-feeding, or intends to become pregnant, from Screening through EoS;
* A history of alcohol or drug abuse in the past 12 months, or current declared alcohol consumption \>4 standard drinks per day for 7 days per week (one standard drink is equivalent to 285 mL of full-strength beer, 100 mL of wine or 30 mL of spirits);
* Use of any prescription medication (with the exception of contraceptives, hormone replacement therapy, or stable doses of medication required for the management of stable, chronic underlying illnesses) within seven days prior to Day 1;
* Use of any investigational drug or device within 30 days, or five half-lives of the drug (whichever is longer) before Day 1, or planned use of another investigational drug or device at any time during the study;
* An employee, or a first-degree family member of an employee, of the Sponsor, Contract Research Organization conducting this study, or study site involved in this study
18 Years
50 Years
ALL
Yes
Sponsors
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Biomedical Advanced Research and Development Authority
FED
Vaxxas Pty Ltd
INDUSTRY
Responsible Party
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Locations
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University of Sunshine Coast Clinical Trials
Morayfield, Queensland, Australia
University of Sunshine Coast Clinical Trials
Sippy Downs, Queensland, Australia
University of Sunshine Coast Clinical Trials
South Brisbane, Queensland, Australia
Doherty Clinical Trials Ltd
East Melbourne, Victoria, Australia
Countries
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Other Identifiers
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SP-1219-007
Identifier Type: -
Identifier Source: org_study_id
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