Neonatologist-performed Lung Ultrasound in the Delivery Room

NCT ID: NCT06408480

Last Updated: 2024-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-01

Study Completion Date

2025-05-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The objective of this study is to evaluate the role of the neonatologist-performed lung ultrasound (NPLUS) during immediate transition after birth of late preterm and full-term neonates using the lung ultrasound score to predict the need of respiratory support persisting more than 1 hour after birth.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Lung ultrasound is an emerging clinical tool to assess the lung in a dynamic way. Recently, the focus has been on establishing lung ultrasound in the neonatal intensive care unit (NICU) as a point-of care application.

Neonates born by a Caesarean section are particularly prone to have an altered adaption to extrauterine life. Especially in the first hours after birth, respiratory distress syndromes (RDS) may occur due to delayed lung fluid clearance after birth.

While acute RDS in the first hours after birth may be a self-limiting disorder and therefore a benign condition, it remains difficult to identify neonates in need for further respiratory support at the NICU. Admission to the NICU not only causes parental stress but also contributes to additional healthcare costs.

There is emerging evidence that NPLUS is a reliable tool to differentiate between the causes leading to RDS in neonates. Using a neonatologist performed lung ultrasound score for the early identification of neonates in need of respiratory support persisting more than 1 hour would be therefore highly advantageous.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neonatal Disease

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

need of respiratory support > 60 min after birth

Group comprises neonates in need of further respiratory support more than 60 minutes after birth.

Neonatologist-performed lung ultrasound

Intervention Type DIAGNOSTIC_TEST

lung ultrasound conducted in min 5, 15, 30, 60 min after birth in late preterm and term infants

need of respiratory support < 60 min after birth

Group comprises neonates that show any signs of respiratory distress in the first 60 minutes, but do not need respiratory support more than 60 minutes after birth.

Neonatologist-performed lung ultrasound

Intervention Type DIAGNOSTIC_TEST

lung ultrasound conducted in min 5, 15, 30, 60 min after birth in late preterm and term infants

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Neonatologist-performed lung ultrasound

lung ultrasound conducted in min 5, 15, 30, 60 min after birth in late preterm and term infants

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Late preterm neonates (born between 34 0/7 and 36 6/7 weeks of gestation) and full-term neonates (born later than 36 6/7 weeks of gestation) delivered by Caesarean section
* Presence of any sign of respiratory distress (defined as tachypnoea/ dyspnoea, grunting, flaring of the nostrils or chest retractions)
* Written informed consent obtained from the parents prior to birth.

Exclusion Criteria

* Presence of cardiopulmonary malformations
* Patients with pneumothorax diagnosed by neonatologist-performed lung ultrasound
Maximum Eligible Age

60 Minutes

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Medical University of Graz

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Bernhard Schwaberger, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Division of Neonatology, Medical University of Graz, Austria

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Division Neonatology, Dp. Pediatrics

Graz, Styria, Austria

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Austria

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Bernhard Schwaberger, MD PhD

Role: CONTACT

+4331638530018

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Melina Winkler, MD

Role: primary

+4331638530271

Bernhard Schwabeger, MD, PhD

Role: backup

+4331638530018

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

36-150 ex 23/24

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

LUS AT BIRTH IN INFANTS BORN BEFORE 26 WEEKS
NCT06394583 NOT_YET_RECRUITING
Lung Sonar in Neonatal Respiratory Disorders
NCT06292338 NOT_YET_RECRUITING
Ultrasound Assessment of BC in the NICU
NCT03241082 ACTIVE_NOT_RECRUITING