Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

800 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-01-01

Study Completion Date

2030-12-31

Brief Summary

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The goal of this observational study is to understand immune responses to viral airway infection in adults, including the elderly. The main question(s) to answer is/are:

Why do some individuals acquire only asymptomatic or mild Influenza A virus (IAV) infection while others become severely ill and even succumb to the same disease?

Participants will be asked to donate samples when seeking health care for influenza-like symptoms or if hospitalized for IAV or SARS-CoV-2. Samples asked for are:

* Blood sample by venepuncture
* Blood sample by capillary sampling
* Nasopharyngeal aspirate
* Nasopharyngeal swab
* Endotracheal tube aspirate
* Nasal swab
* Nasal curette
* Breath Explor (sampling of expired air)

Researchers will compare obtained results with the same type of samples from healthy controls.

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Detailed Description

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This observational study will specifically investigate different immunological parameters in blood and at the site of infection in patients with IAV symptoms or confirmed infection to understand parameters related to disease course. Blood and airway samples will be analyzed for immune cell subsets and their functionality, antibodies and other soluble mediators and linked to clinical data. Immune cells will be analyzed using multi-color flow cytometry, RNA sequencing, and in vitro functionality assays. Fluids (plasma, serum, supernatants from airway samples and cell culture supernatants) will be analyzed using ELISA (and or similar methods), proximity extension assay (Olink), etc.

Conditions

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Influenza A Infection Influenza B Virus Infection SARS CoV 2 Infection RSV Infection

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients

Patients with airway infection. Enrolled while seeking health care or when hospitalized.

No interventions assigned to this group

Controls

Subjects without airway infection.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Influenza A like symptoms and/or
* Confirmed airway infection

Exclusion Criteria

* Current malignancies
* Immunosuppressive treatment, not including/except hydrocortisone

* Airway infection within the past four weeks
* Ongoing antibiotic treatment
* Immunosuppressive treatment

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes