Remimazolam for Emergence Delirium Prevention in Patients Undergoing Rhinoseptoplasty, FESS or Septoplasty

NCT ID: NCT06398275

Last Updated: 2024-05-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-06

Study Completion Date

2024-12-31

Brief Summary

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The aim of this research is to confirm the effectiveness of remimazolam in preventing delirium during recovery from anesthesia in adult patients who have undergone one of the rhinological surgeries (septoplasty, rhinoseptoplasty or functional endoscopic sinus surgery).

Patients aged 18-65, ASA classification I-II will be anesthetized with balanced anesthesia maintained with sevoflurane and will be randomized into two groups. The first group will receive remimazolam before anesthesia, while the second will receive normal saline solution.

The main outcome of the study will be the presence/absence of delirium during anesthesia recovery, while the secondary outcome will be the postoperative pain level, the length of stay in the recovery room, the presence of unwanted events in the recovery room, and the presence of postoperative mood changes.

Detailed Description

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Conditions

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Remimazolam Emergence Delirium Rhinoplasty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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1

Group Type EXPERIMENTAL

Remimazolam 20 MG Injection [Byfavo]

Intervention Type DRUG

Remimazolam 0.1 mg/kg intravenous injection

2

Group Type PLACEBO_COMPARATOR

NaCl 0.9%

Intervention Type DRUG

NaCl 0.9% 0.04 mL/kg

Interventions

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Remimazolam 20 MG Injection [Byfavo]

Remimazolam 0.1 mg/kg intravenous injection

Intervention Type DRUG

NaCl 0.9%

NaCl 0.9% 0.04 mL/kg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients scheduled for rhinoplasty, rhinoseptoplasty or FESS
* ASA I or II

Exclusion Criteria

* pregnancy
* patients treated with psychiatric medication (in the time of operation or 6 months prior to operation)
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital of Split

OTHER

Sponsor Role lead

Responsible Party

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Grgur Prižmić

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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UH Split

Split, , Croatia

Site Status RECRUITING

Countries

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Croatia

Central Contacts

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Grgur Prižmić

Role: CONTACT

+385994213808

Facility Contacts

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Grgur Prižmić

Role: primary

+385994213808

Other Identifiers

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520-03/24-01/14

Identifier Type: -

Identifier Source: org_study_id

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