Identification of Biomarkers Associated With the Presence of Malignant Pancreatic Lesions Compared to Benign Lesions.

NCT ID: NCT06397846

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-12-11

Study Completion Date

2027-06-30

Brief Summary

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The challenge for medical oncology is to develop plasma biomarkers that can detect the influence of the stroma on diagnosis, prognosis and response to chemotherapy.

Today, there is no validated blood test to help diagnose pancreatic cancer (PDAC). The search for blood biomarkers of the tumor stroma and immunological markers is therefore a major challenge in orienting the diagnosis towards PDAC and optimizing the therapeutic management of pancreatic cancers.

The aim of the study is to identify biomarkers associated with the presence of malignant pancreatic lesions (patients from the Pancreas-CGE cohort, a cohort already set up by our team) compared with benign lesions (patients followed up for benign pancreatic lesions). Candidate biomarkers from our preliminary work will be considered initially. Other biomarkers may be explored secondarily.

The ultimate goal is to develop a clinico-biological signature that is as efficient as possible in predicting the presence of malignant pancreatic lesions compared with benign ones.

Detailed Description

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Conditions

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Benign Pancreatic Lesion

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Biological sample

Blood sample

Group Type EXPERIMENTAL

Biological sample

Intervention Type OTHER

blood sample will be collected at baseline

Interventions

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Biological sample

blood sample will be collected at baseline

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men and women ≥18 years
* Patient followed for benign pancreatic lesions:

chronic pancreatitis acute pancreatitis at a distance from the acute episode (\> 4 weeks) with indication for echo-endoscopy for suspected precancerous pancreatic lesions (PanIN, TIPMP, mucinous cystadenomas) or other cystic lesions (serous cystadenomas)

Exclusion Criteria

* Malignant pancreatic tumor
* Legal incapacity or limited legal capacity
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Besancon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University Hospital of Besancon

Besançon, , France

Site Status RECRUITING

Hôpital Nord Franche-Comté

Montbéliard, , France

Site Status NOT_YET_RECRUITING

Countries

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France

Central Contacts

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Angélique VIENOT, Dr

Role: CONTACT

Phone: +3381479999

Email: [email protected]

Marion JACQUIN

Role: CONTACT

Email: [email protected]

Facility Contacts

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Angélique VIENOT, Dr

Role: primary

Other Identifiers

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2023/842

Identifier Type: -

Identifier Source: org_study_id