Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
2000 participants
OBSERVATIONAL
2023-03-15
2026-06-18
Brief Summary
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Detailed Description
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To address this problem, the researchers have developed a new method to analyze circulating vesicles (called exosomes), which contain specific genetic material called microRNAs (miRNAs). In a previous study, by analyzing both the miRNAs that circulate freely in serum and the miRNAs that are inside the exosomes, the researchers have already identified a combination of 13 miRNAs that could accurately detect early-stage PDAC.
In this study, the researchers will test this method in a larger international cohort study. This study aims to confirm the effectiveness of this approach in identifying PDAC at its earliest stages.
Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Patients with Pancreatic Cancer Ductal Adenocarcinoma (Training)
Individuals diagnosed with pancreatic ductal adenocarcinoma
PANcreatic cancer Exosome Early detectiON (PANXEON)
This test will utilize quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to quantify the expression levels of 5 cell-free and 8 exosome-miRNAs in plasma samples obtained from patients with pancreatic ductal adenocarcinoma and from individuals without it
Individuals without Pancreatic Cancer Ductal Adenocarcinoma (Training)
Individuals without pancreatic ductal adenocarcinoma
PANcreatic cancer Exosome Early detectiON (PANXEON)
This test will utilize quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to quantify the expression levels of 5 cell-free and 8 exosome-miRNAs in plasma samples obtained from patients with pancreatic ductal adenocarcinoma and from individuals without it
Patients with Pancreatic Cancer Ductal Adenocarcinoma (Validation)
Individuals diagnosed with pancreatic ductal adenocarcinoma
PANcreatic cancer Exosome Early detectiON (PANXEON)
This test will utilize quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to quantify the expression levels of 5 cell-free and 8 exosome-miRNAs in plasma samples obtained from patients with pancreatic ductal adenocarcinoma and from individuals without it
Individuals without Pancreatic Cancer Ductal Adenocarcinoma (Validation)
Individuals without pancreatic ductal adenocarcinoma
PANcreatic cancer Exosome Early detectiON (PANXEON)
This test will utilize quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to quantify the expression levels of 5 cell-free and 8 exosome-miRNAs in plasma samples obtained from patients with pancreatic ductal adenocarcinoma and from individuals without it
Interventions
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PANcreatic cancer Exosome Early detectiON (PANXEON)
This test will utilize quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) to quantify the expression levels of 5 cell-free and 8 exosome-miRNAs in plasma samples obtained from patients with pancreatic ductal adenocarcinoma and from individuals without it
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment.
* Imaging- or endoscopy-based proof of lack of pancreatic ductal adenocarcinoma at the time of sampling (Non-disease controls)
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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City of Hope Medical Center
OTHER
Responsible Party
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Principal Investigators
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Ajay Goel, PhD
Role: PRINCIPAL_INVESTIGATOR
City of Hope Medical Center
Locations
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Translational Genomics Research Institute
Phoenix, Arizona, United States
Honorhealth
Scottsdale, Arizona, United States
City of Hope Medical Center
Monrovia, California, United States
Hoag Center
Newport Beach, California, United States
OSF HealthCare
Peoria, Illinois, United States
Ochsner Medical Center
Jefferson, Louisiana, United States
Atlantic Health System
Morristown, New Jersey, United States
Piedmont Medical Center
Rock Hill, South Carolina, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Nagoya University
Nagoya, , Japan
Asan Medical Center
Seoul, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Daniel Von Hoff
Role: primary
Erkut Borazanci
Role: primary
Ajay Goel, PhD
Role: primary
Michael Demeure
Role: primary
Chandler Wilfong
Role: primary
John Bolton
Role: primary
Angela Alistar
Role: primary
Andrew Page
Role: primary
Douglas Evans
Role: primary
Yasuhiro Kodera
Role: primary
Song Cheol Kim
Role: primary
References
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Other Identifiers
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19288/PCDC
Identifier Type: -
Identifier Source: org_study_id