Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
225 participants
OBSERVATIONAL
2024-06-30
2026-07-31
Brief Summary
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\- Does oscillometry with reversibility testing increase diagnostic accuracy in detection of asthma in adults when added to spirometry with reversibility and FeNO?
Researchers will evaluate the diagnostic accuracy of this approach with the reference standard, which is a clinically adjudicated diagnosis of asthma by two respiratory clinicians based on history and investigation results.
Participants will
* Undergo oscillometry testing alongside their routine asthma investigations within their scheduled clinic visit
* Optionally participate in our sub-studies on new breath and nasal swab tests for asthma
* Optionally participate in our qualitative substudy on patients views and attitudes to asthma testing and oscillometry
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Interventions
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Oscillometry with reversibility testing
Oscillometry is a test that uses sound waves to measure the mechanical properties in the lungs during tidal breathing
Breath volatile testing
We will be optimising and evaluating the sensitivity and specificity of a novel breath volatile organic compound test of a combination of reactive aldehydes using a gas chromatography-ion mobility spectrometry device
Nasal eosinophil peroxidase
We will be evaluating the sensitivity and specificity of a novel nasal swab test for eosinophil peroxidase
Handheld capnometry
We will be evaluating handheld capnometry (carbon dioxide breath testing) to diagnose adult asthma
Eligibility Criteria
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Inclusion Criteria
* Ageā„18 years
* Willing to allow his or her General Practitioner and consultant, if appropriate, to be notified of participation in the study
* Able to give informed consent
Exclusion Criteria
* A chest infection or exacerbation requiring antibiotics or steroids within 4 weeks of testing
* Contraindications to spirometry testing
* Established or coded diagnosis of COPD
* Pregnancy or lactating
* Other medical condition that in the opinion of the investigator would preclude compliance with the study protocoll
* Inability to understand English
* Involvement in Clinical Trial of an Investigational Medicinal Product
18 Years
ALL
No
Sponsors
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Asthma UK
OTHER
General Practitioners Research Institute
NETWORK
Imperial College London
OTHER
Responsible Party
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Locations
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Imperial College Healthcare NHS Trust
London, , United Kingdom
Imperial College Healthcare NHS Trust
London, , United Kingdom
Nottingham University Hospitals NHS Trust
Nottingham, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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24SM8792
Identifier Type: -
Identifier Source: org_study_id
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