Resistance Training and Corticospinal Excitability in Multiple Sclerosis
NCT ID: NCT06374108
Last Updated: 2024-12-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
54 participants
INTERVENTIONAL
2024-05-01
2026-05-31
Brief Summary
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Detailed Description
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The functional CNS changes have been evidenced by using the non invasive brain stimulation technique Transcranial Magnetic Stimulation, showing decreased corticospinal excitability alongside increased central motor conduction time. Moreover, functional peripheral nervous system (PNS) changes have been evidenced by nerve conduction methods, revealing decreased amplitude of compound muscle action potential and increased latency of nerve signaling. In an ongoing exploratory study (unpublished), the investigators have observed that functional CNS and PNS outcomes deteriorate with disability progression from healthy to mildly to moderately disabled people with MS (PwMS).
Exercise is beneficial from both an individual and a societal perspective, and has proven to be both safe and without any noticeable side effects in PwMS. Resistance training (RT) appears particularly effective in improving neuromuscular function (mainly muscle strength) and physical function (especially walking capacity). Whilst RT and other exercise modalities may elicit positive effects on CNS structure in PwMS, it seems to require a long-term (≥ 6 months) exposure. In contrast, CNS (and potentially PNS) function may adapt much more rapidly, despite a scarcity of studies (and with heterogeneous findings) involving PwMS. Interestingly, an exploratory exercise study (non-controlled, low sample size, 10 weeks treadmill walking intervention) assessed corticospinal excitability in PwMS, and observed substantial improvements after the intervention. Apart from this study, a major knowledge gap exists in terms of elucidating the potential beneficial effects of exercise (RT in particular) on CNS (and PNS) function. Based on evidence from healthy young individuals, substantial improvements in corticospinal excitability have been shown following 2-12 weeks of RT, supporting that RT-induced improvements in corticospinal excitability can also be seen in PwMS. Lastly, as existing exercise guidelines for PwMS fails to refer to evidence on dose-response to exercise, and a recent systematic review on exercise studies found no dose-response studies in PwMS (n=202), this aspect is also of great clinical relevance.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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High dose resistance training
10 weeks intervention with 2.5 weekly supervised resistance training sessions (2 or 3 sessions/week for high dose resistance training; 25 sessions in total).
Progressive resistance training
The RT exercise regime will focus on lower extremity exercises (60-90% of 1 repetition maximum) as well as incorporating functional exercises.
Low dose resistance training
10 weeks intervention with 1 weekly supervised resistance training session (low dose resistance training; 10 sessions in total).
Progressive resistance training
The RT exercise regime will focus on lower extremity exercises (60-90% of 1 repetition maximum) as well as incorporating functional exercises.
Waitlist control.
The waitlist control group will initially be instructed to maintain their normal daily activity during the 10 week intervention period. Hereafter, they will be offered a 10 week high dose resistance training intervention that combines supervised and home based exercise sessions .
No interventions assigned to this group
Interventions
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Progressive resistance training
The RT exercise regime will focus on lower extremity exercises (60-90% of 1 repetition maximum) as well as incorporating functional exercises.
Eligibility Criteria
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Inclusion Criteria
* MS diagnosis according to the McDonald diagnostic criteria
* Shows impairments in walking capacity
* Ability to self transport to test and exercise
Exclusion Criteria
* Neurological or other comorbidities that affects the nervous system
* Relapse within the past 2 months
* Pacemaker or metallic implants
* Hypertension (medically unregulated)
* Participation in structured RT over the past 3 months (≥ 2 sessions/week).
18 Years
ALL
No
Sponsors
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Aarhus University Hospital
OTHER
University of Copenhagen
OTHER
University of Aarhus
OTHER
Responsible Party
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Locations
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Department of Public Health
Aarhus, Central Jutland, Denmark
Department of Nutrition, Exercise and Sports, University of Copenhagen
Copenhagen, Copenhagen N, Denmark
Countries
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Central Contacts
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Facility Contacts
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Annette Bachmann
Role: primary
Kristian Levring Madsen
Role: primary
Other Identifiers
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Neuro_Exercise
Identifier Type: -
Identifier Source: org_study_id