Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
NCT ID: NCT06359496
Last Updated: 2024-04-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
1 participants
OBSERVATIONAL
2024-02-23
2024-04-02
Brief Summary
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Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial.
This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.
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Detailed Description
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Liver transplantation (LT) is an effective treatment for end-stage liver disease. As a traditional marginal donor liver, the application of SLT in pediatric patients is successful.However, its application in adult liver transplantation, especially in HCC patients, remains controversial.
This retrospective study analyze outcomes among adults who underwent SLT and whole liver transplantation (WLT) at two centers from January 2018 to August 2022. A 1:1 propensity score matching (PSM) analysis was performed based on important donor and recipient variables. Baseline characteristics and postoperative outcomes of the above recipients were analyzed and compared. Statistical significance was determined using a two-sided p-value threshold of less than 0.05.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Interventions
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No intervention factor
No intervention factor
Eligibility Criteria
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Inclusion Criteria
2. Received a liver transplantation between 2018 and 2022 (3) Liver transplantation was performed by SLT or WLT
Exclusion Criteria
2. Multiorgan transplantation
3. Survival≤one week after LT
4. Incomplete data
ALL
Yes
Sponsors
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Zhejiang University
OTHER
Responsible Party
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Xiao Xu
Principal Investigator, Clinical Professor，PHD，MD
Locations
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Xiao Xu
Hangzhou, , China
Countries
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Other Identifiers
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CT2024-ZJU-OBS8
Identifier Type: -
Identifier Source: org_study_id
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