Tenofovir Disoproxil Fumarate in the Treatment of Parkinson's Disease

NCT ID: NCT06356662

Last Updated: 2025-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE1

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-23

Study Completion Date

2025-12-31

Brief Summary

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To evaluate the efficacy and safety of tenofovir disoproxil fumarate in the treatment of Parkinson's disease. The changes of motor symptoms and the occurrence of adverse reactions in early Parkinson's disease patients who took tenofovir disoproxil fumarate and did not take Tenofovir disoproxil fumarate at different time points were compared.

Detailed Description

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Conditions

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Parkinson Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Tenofovir

patients with parkinson's disease

Group Type EXPERIMENTAL

Tenofovir Disoproxil Fumarate

Intervention Type DRUG

take tenofovir disoproxil fumarate 300mg/d

Placebo

patients with parkinson's disease

Group Type PLACEBO_COMPARATOR

Tenofovir Disoproxil Fumarate

Intervention Type DRUG

take tenofovir disoproxil fumarate 300mg/d

Interventions

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Tenofovir Disoproxil Fumarate

take tenofovir disoproxil fumarate 300mg/d

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 1: Parkinson's disease: Hoehn Yahr= 1 to 2.5 2: MMSE score≄24

Exclusion Criteria

* 1: essential tremor, stroke, epilepsy and other well-defined neurological disorders

2: Or have received deep brain stimulation and other brain surgery

3: Abnormal liver and kidney function

4: Infected with chronic hepatitis B or AIDS (HIV-1 infection)

5: Severe depression, schizophrenia, other psychiatric disorders or drug dependence

6: Other serious physical diseases such as heart, lung, liver, kidney disease, blood disease and malignant tumor

7: Pregnant or lactating women and seniors over 65 years of age

8: Allergy or other contraindications to the investigational drug
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Fourth Affiliated Hospital of Zhejiang University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Guohua Zhao

Hangzhou, Zhejiang, China

Site Status RECRUITING

Countries

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China

Facility Contacts

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Zhao Guohua, Doctor

Role: primary

+86 13777812308

Other Identifiers

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KY-2023-198

Identifier Type: -

Identifier Source: org_study_id

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