Dynamic Data-Driven Management of Atrial Fibrillation Using Implantable Cardiac Monitors: The MONITOR-AF Study

NCT ID: NCT06352060

Last Updated: 2025-04-18

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

598 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2021-12-31

Brief Summary

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Observational, multi-center, retrospective study to evaluate the use of ICM (implantable cardiac monitor) versus traditional, non-ICM (non-implantable cardiac monitor) methods such as ECGs (electrocardiogram), Holter, and mobile cardiac outpatient telemetry (MCOT) units.

Detailed Description

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Even with its increasing popularity and use, the impact of ICMs on AF (atrial fibrillation) management is still being determined and can even be conflicting. Furthermore, the use of ICM is dependent on physician preference. It is hypothesized that dynamic monitoring with ICMs is superior to conventional methods and should be used for all patients with AF. Thus, it aimed to measure the outcomes of using ICM versus more traditional approaches in patients with AF.

Conditions

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Atrial Fibrillation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Participants with ICM

Patients who underwent ICM insertion

No intervention or administration will be performed due to the observational nature of the study

Intervention Type OTHER

Charts of patients enrolled in the study will be reviewed for an initial monitoring method and any changes in management.

Non-ICM Participants

Patients with traditional monitoring methods

No intervention or administration will be performed due to the observational nature of the study

Intervention Type OTHER

Charts of patients enrolled in the study will be reviewed for an initial monitoring method and any changes in management.

Interventions

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No intervention or administration will be performed due to the observational nature of the study

Charts of patients enrolled in the study will be reviewed for an initial monitoring method and any changes in management.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients \> 18 years of age
* Present for management of AF
* ICM is inserted at the discretion of the treating physician

Exclusion Criteria

* Patients \< 18 years of age
* Presence of a permanent pacemaker, implantable cardiac defibrillator, or cardiac resynchronization therapy
* Unable to tolerate ICM or traditional monitoring with ECG, Holter, or MCOT monitoring
* Unable to tolerate AAD, OAC, and CA as part of AF standard of care
* ICM inserted for cryptogenic stroke or syncope
* Was not followed \> 12 months
* CA performed for AF before ICM implant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kansas City Heart Rhythm Research Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dhanunjaya Lakkireddy

Role: PRINCIPAL_INVESTIGATOR

Kansas City Heart Rhythm Institute

Locations

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Menorah Medical Center

Overland Park, Kansas, United States

Site Status

Kansas City Heart Rhythm Institute - Roe Clinic

Overland Park, Kansas, United States

Site Status

Overland Park Regional Medical Center

Overland Park, Kansas, United States

Site Status

Centerpoint Medical Center Clinic

Independence, Missouri, United States

Site Status

Centerpoint Medical Center

Independence, Missouri, United States

Site Status

Research Medical Center Clinic

Kansas City, Missouri, United States

Site Status

Research Medical Center

Kansas City, Missouri, United States

Site Status

Countries

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United States

References

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Israel CW, Gronefeld G, Ehrlich JR, Li YG, Hohnloser SH. Long-term risk of recurrent atrial fibrillation as documented by an implantable monitoring device: implications for optimal patient care. J Am Coll Cardiol. 2004 Jan 7;43(1):47-52. doi: 10.1016/j.jacc.2003.08.027.

Reference Type BACKGROUND
PMID: 14715182 (View on PubMed)

Reiffel JA, Verma A, Kowey PR, Halperin JL, Gersh BJ, Elkind MSV, Ziegler PD, Kaplon RE, Sherfesee L, Wachter R; REVEAL AF Investigators. Rhythm monitoring strategies in patients at high risk for atrial fibrillation and stroke: A comparative analysis from the REVEAL AF study. Am Heart J. 2020 Jan;219:128-136. doi: 10.1016/j.ahj.2019.07.016.

Reference Type BACKGROUND
PMID: 31862084 (View on PubMed)

Svendsen JH, Diederichsen SZ, Hojberg S, Krieger DW, Graff C, Kronborg C, Olesen MS, Nielsen JB, Holst AG, Brandes A, Haugan KJ, Kober L. Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial. Lancet. 2021 Oct 23;398(10310):1507-1516. doi: 10.1016/S0140-6736(21)01698-6. Epub 2021 Aug 29.

Reference Type BACKGROUND
PMID: 34469766 (View on PubMed)

Reiffel JA, Verma A, Kowey PR, Halperin JL, Gersh BJ, Wachter R, Pouliot E, Ziegler PD; REVEAL AF Investigators. Incidence of Previously Undiagnosed Atrial Fibrillation Using Insertable Cardiac Monitors in a High-Risk Population: The REVEAL AF Study. JAMA Cardiol. 2017 Oct 1;2(10):1120-1127. doi: 10.1001/jamacardio.2017.3180.

Reference Type BACKGROUND
PMID: 28842973 (View on PubMed)

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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KCHRRF_MONITOR AF_030

Identifier Type: -

Identifier Source: org_study_id

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