Efficacy and Safety of AJU-S56 in Dry Eye Syndrome Patients

NCT ID: NCT06337981

Last Updated: 2024-04-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

99 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-11-22

Study Completion Date

2022-11-28

Brief Summary

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This study is planned to Evaluate the Efficacy and Safety of test drug (AJU-S56) compared to control drug(vehicle) in Patients with Dry Eye Disease.

Detailed Description

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Conditions

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Dry Eye Syndromes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Test group 1

(AJU-S56 5%) and placebo(Vehicle), 1drop/1times, 3times in a day

Group Type EXPERIMENTAL

(AJU-S56 5% and placebo)

Intervention Type DRUG

(AJU-S56 5%) and placebo(Vehicle), 1drop/1times, 3times in a day

Test group 2

(AJU-S56 5%), 1drop/1times, 6times in a day

Group Type EXPERIMENTAL

AJU-S56 5%

Intervention Type DRUG

(AJU-S56 5%), 1drop/1times, 6times in a day

Comparator group

Placebo(Vehicle), 1drop/1times, 6times in a day

Group Type PLACEBO_COMPARATOR

Placebo(Vehicle)

Intervention Type DRUG

Placebo(Vehicle), 1drop/1times, 6times in a day

Interventions

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(AJU-S56 5% and placebo)

(AJU-S56 5%) and placebo(Vehicle), 1drop/1times, 3times in a day

Intervention Type DRUG

AJU-S56 5%

(AJU-S56 5%), 1drop/1times, 6times in a day

Intervention Type DRUG

Placebo(Vehicle)

Placebo(Vehicle), 1drop/1times, 6times in a day

Intervention Type DRUG

Other Intervention Names

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Test 1 group(AJU-S56 5% and placebo, each 1 drop/1time, 3times in a day) Test 2 group(AJU-S56 5%, 1 drop/1time, 6times in a day) Placebo group(Vehicle, 1 drop/1time, 6times in a day)

Eligibility Criteria

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Inclusion Criteria

* Male and Female who over 19 years old
* Moderate to Severe Dry Eye Disease Patients
* Must meet all criteria listed below at least in one eye or both eyes. TCSS (National eye institute (NEI) scale)≥ 4 Schirmer test(without anesthesia) ≤ 10mm in 5 mins Tear break-up time ≤ 6 secs
* Written informed consent to participate in the trial

Exclusion Criteria

* Those who have clinically significant eye disease not related to dry eye syndrome
* Those who have medical history with intraocular surgery 12months before screening visit
* Use of corticosteroid, beta blocker and anticholinergic agent within 4 weeks
* Participation in other studies within 4weeks of screening visit
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GL Pharm Tech Corporation

INDUSTRY

Sponsor Role collaborator

AJU Pharm Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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AJU Pharm Co., Ltd.

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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21DE20901

Identifier Type: -

Identifier Source: org_study_id

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