HS-20089 Combination Treatment in Subjects With Advanced Solid Tumors

NCT ID: NCT06336707

Last Updated: 2024-07-18

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 1048 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-04-11
• Study Completion Date: 2028-04-08

Brief Summary

HS-20089 is an investigational antibody-drug conjugate (ADC) composed of a humanized IgG1 anti-B7-H4 monoclonal antibody conjugated to the topoisomerase I inhibitor payload via a protease-cleavable linker, with an average drug-to-antibody ratio of about 6.

This is a phase Ⅰ, open-label, multi-center study to evaluate the safety, tolerability, pharmacokinetics (PK) and efficacy of HS-20089 in combination with other antitumor agents (Adebrelimab with or without platinum; Bevacizumab with or without platinum) in subjects with advanced solid tumors.

Detailed Description

This study contains four combination therapy cohorts, each consisting of a dose exploration part and a dose expansion part.

The dose exploration part will explore the corresponding optimal dose level of HS-20089 in each combination therapy. The dose expansion part will be conducted at 1 or 2 safe and potentially effective dose levels in subjects with selected tumors in each cohort.

The cohorts may be adjusted based on the observed clinical results, translational medicine data and research progress in the field.

Conditions

Advanced Solid Tumors

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

HS-20089 and Adebrelimab

Group Type: EXPERIMENTAL

HS-20089

Intervention Type: DRUG

Intravenous infusion

Adebrelimab

Intervention Type: DRUG

Intravenous infusion

HS-20089, Adebrelimab and cisplatin / carboplatin

Group Type: EXPERIMENTAL

HS-20089

Intervention Type: DRUG

Intravenous infusion

Adebrelimab

Intervention Type: DRUG

Intravenous infusion

Cisplatin / carboplatin

Intervention Type: DRUG

Intravenous infusion

HS-20089 and Bevacizumab

Group Type: EXPERIMENTAL

HS-20089

Intervention Type: DRUG

Intravenous infusion

Bevacizumab

Intervention Type: DRUG

Intravenous infusion

HS-20089, Bevacizumab and cisplatin / carboplatin

Group Type: EXPERIMENTAL

HS-20089

Intervention Type: DRUG

Intravenous infusion

Bevacizumab

Intervention Type: DRUG

Intravenous infusion

Cisplatin / carboplatin

Intervention Type: DRUG

Intravenous infusion

Interventions

HS-20089

Intravenous infusion

Intervention Type: DRUG

Adebrelimab

Intravenous infusion

Intervention Type: DRUG

Bevacizumab

Intravenous infusion

Intervention Type: DRUG

Cisplatin / carboplatin

Intravenous infusion

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Males or females aged 18 years or older (≥18 years).

2. Patients diagnosed with pathologically confirmed advanced solid tumors.

3. Subjects have at least one target lesion as assessed per the RECIST 1.1. Patients with only brain and/or bone lesions as target lesions are ineligible.

4. Agree to provide fresh or archival tumor tissue

5. Eastern Cooperative Oncology Group Performance Status (ECOG PS) score of 0 to 1 and no deterioration within 2 weeks before the first dose.

6. Have a life expectancy of at least 12 weeks.

7. Female subjects of childbearing potential are willing to take appropriate contraceptive measures and should not breastfeed from signing the informed consent until 6 months after the last dose; male subjects must agree to use barrier contraception (i.e. condoms) from signing the informed consent to 6 months after the last dose.

8. Female subjects must have a negative pregnancy test within 7 days prior to the first dose (for subjects with tumor related abnormal elevation of human chorionic gonadotropin [HCG], an ultrasound of uterus and appendages should be performed within 7 days prior to the first dose to rule out pregnancy), or demonstrate no risk for pregnancy.

9. Subject must be voluntarily enrolled in this clinical trial, be able to understand the study procedures and to sign written informed consent.

Exclusion Criteria

1. Have received or is currently receiving the following treatment: B7-H4-targeted therapies; Have received any of cytotoxic chemotherapy drugs, investigational drugs, anti-tumor traditional Chinese medicines or other anti-tumor drugs within 14 days prior to the first dose of study drug; or need to continue these drugs during the study.

2. Presence of Grade ≥ 2 toxicities as per Common Terminology Criteria for Adverse Events due to prior anti-tumor therapy.

3. Presence of pleural/abdominal effusion requiring clinical intervention.

4. Known history of other primary malignancy.

5. Evidence of brain metastasis and/or cancerous meningitis

6. Inadequate bone marrow reserve or hepatic/renal functions.

7. Cardiological examination abnormality.

8. Severe, uncontrolled or active cardiovascular disorders.

9. Serious or poorly controlled diabetes.

10. Serious or poorly controlled hypertension.

11. Clinically significant bleeding symptoms or significant bleeding tendency within 1 month prior to the first dose of study treatment.

12. Serious infections within 4 weeks prior to the first dose.

13. Have received systemic glucocorticoid therapy for more than 7 days within 28 days prior to the first dose study treatment, or require chronic (≥ 7 days) use of systemic glucocorticoids during the study, or have other acquired, congenital immunodeficiency disorders, or a history of organ transplantation.

14. Presence of active infectious diseases such as hepatitis B, hepatitis C, tuberculosis, syphilis, or human immunodeficiency virus infection, etc.

15. Current hepatic encephalopathy, hepatorenal syndrome, or Child-Pugh Class B or more severe cirrhosis.

16. Any moderate or severe lung diseases that may interfere with the detection and treatment of drug-related pulmonary toxicity or may seriously affect respiratory function.

17. History of severe neurological or psychiatric disorder.

18. Pregnant or breast-feeding women or women who intend to become pregnant during the study.

19. Attenuated live vaccination within 4 weeks prior to the first dose.

20. Subjects with autoimmune disease that is active or is likely to recur.

21. Subjects with gastrointestinal fistula, visceral fistula, gastrointestinal perforation, or abdominal abscess, or with symptoms/signs of intestinal obstruction within 6 months prior to the first dose of study drug.

22. Subjects unlikely to comply with study procedures, restrictions and requirement as determined by the investigator.

23. Subjects with any condition that jeopardizes the safety of the patient or interferes with the assessment of the study, as judged by the investigator.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hansoh BioMedical R&D Company

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology

Shanghai, Shanghai Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Ding Ma, PhD

Role: CONTACT

dma@tjh.tjmu.edu.cn

(0086)13886090620

Facility Contacts

Ding Ma, PhD

Role: primary

dma@tjh.tjmu.edu.cn

(0086)13886090620

Other Identifiers

HS-20089-103

Identifier Type: -

Identifier Source: org_study_id