Point-of-Care Ultrasound (POCUS) Findings and Impact on Vaping
NCT ID: NCT06335329
Last Updated: 2025-11-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
200 participants
INTERVENTIONAL
2024-07-17
2026-02-28
Brief Summary
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To our knowledge, there are no studies evaluating the lung ultrasound findings of asymptomatic vapers. However, there is data to suggest that vaping can lead to pulmonary toxicity in in-vitro and animal models, including increased inflammatory cytokines, hyperreactivity, and oxidative stress. In addition, studies found the risk of bronchitic symptoms is twice as likely in current adolescent vapers, compared to those who have never vaped before. Given the potential pulmonary toxicity of vaping, as well as the increased percentage of adolescent vaping activity in recent years, investigators aim to evaluate baseline lung ultrasound findings in adolescents who vape. Concurrently, investigators will assess if observing their lung ultrasound findings can alter their attitudes and behaviors towards vaping. Prior adult studies have found that showing patients' their atherosclerosis plaque increased the motivation to quit and cessation rates. Additionally, data in pregnant patients found real-time ultrasound feedback of smoking effects on the fetus lead to near abstinence in light smokers. Given the frequent use of point-of-care ultrasound in the emergency department, investigators hope to assess an innovative intervention for cessation.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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standard vaping cessation counseling (SOC) + ultrasound (US)
Participants will receive SOC via a publicly available infographic from the Food and Drug Administration). They will also be provided with a discussion of lung US findings
Discussion of point-of-care ultrasound lung findings
The investigator will obtain point-of-care ultrasound images to assess the lung findings in 12 lung fields. These 12 lung fields will include the standard protocol of the upper and lower halves of the anterior, lateral, and posterior chest bilaterally. Subjects' ultrasound images will be scored using a modified lung ultrasound score (LUS). Each of the 12 lung fields will be scored from 0-5, with a total score of 0-60 (noted below). The participants will watch their ultrasound being performed, looking at their lungs in real time. Then, the ultrasound findings will be discussed with the participant.
Modified LUS 0: No B-lines present
1. 1 well-defined B-line
2. 2-3 well-defined B-lines
3. \>3 B-lines
4. Confluent B-lines
5. Lobar consolidation
* C: Noted if subpleural consolidation present
* E: Noted if pleural effusion present
Standard vaping cessation counseling (SOC) alone
Participants will receive a SOC alone. They will be kept blinded to their lung point-of-care ultrasound findings and will not be able to visualize the images as the ultrasound is performed.
No interventions assigned to this group
Interventions
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Discussion of point-of-care ultrasound lung findings
The investigator will obtain point-of-care ultrasound images to assess the lung findings in 12 lung fields. These 12 lung fields will include the standard protocol of the upper and lower halves of the anterior, lateral, and posterior chest bilaterally. Subjects' ultrasound images will be scored using a modified lung ultrasound score (LUS). Each of the 12 lung fields will be scored from 0-5, with a total score of 0-60 (noted below). The participants will watch their ultrasound being performed, looking at their lungs in real time. Then, the ultrasound findings will be discussed with the participant.
Modified LUS 0: No B-lines present
1. 1 well-defined B-line
2. 2-3 well-defined B-lines
3. \>3 B-lines
4. Confluent B-lines
5. Lobar consolidation
* C: Noted if subpleural consolidation present
* E: Noted if pleural effusion present
Eligibility Criteria
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Inclusion Criteria
* Has own individual cell phone or email for communication
* Member of a vaping history group that is not yet full for enrollment (ex: up to 100 vapers, up to 100 non-vapers)
* Able to speak and understand English
Exclusion Criteria
* History of pneumothorax
* Prior thoracic surgery including VATS (Video-assisted thoracoscopic surgery)
* Sickle cell disease
* Current or prior cancer
* Significant congenital heart disease
* Acute upper respiratory infection (cough or congestion in the last 3 days)
* Acute chest trauma
* Acute pulmonary embolism
* Sedation medication administered prior to study image acquisition
* Known allergy or sensitivity to ultrasound gel
* Significant acute psychosis, mania, or suicidal ideation
* Any other medical or psychiatric condition or other significant concern that in the investigator's opinion would impact participant safety or compliance with study instructions, or potentially confound the interpretation of findings
* Inability or unwillingness of subject or legal guardian/representative to give informed consent/assent.
12 Years
18 Years
ALL
Yes
Sponsors
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Medical University of South Carolina
OTHER
Responsible Party
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Locations
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Medical University of South Carolina
Charleston, South Carolina, United States
Countries
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Facility Contacts
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Kaitlyn M Boggs, MD
Role: primary
References
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Gorukanti A, Delucchi K, Ling P, Fisher-Travis R, Halpern-Felsher B. Adolescents' attitudes towards e-cigarette ingredients, safety, addictive properties, social norms, and regulation. Prev Med. 2017 Jan;94:65-71. doi: 10.1016/j.ypmed.2016.10.019. Epub 2016 Oct 20.
Overbeek DL, Kass AP, Chiel LE, Boyer EW, Casey AMH. A review of toxic effects of electronic cigarettes/vaping in adolescents and young adults. Crit Rev Toxicol. 2020 Jul;50(6):531-538. doi: 10.1080/10408444.2020.1794443. Epub 2020 Jul 27.
Fadus MC, Smith TT, Squeglia LM. The rise of e-cigarettes, pod mod devices, and JUUL among youth: Factors influencing use, health implications, and downstream effects. Drug Alcohol Depend. 2019 Aug 1;201:85-93. doi: 10.1016/j.drugalcdep.2019.04.011. Epub 2019 May 23.
Other Identifiers
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Pro00133616
Identifier Type: -
Identifier Source: org_study_id