A Study of GH21 Combined With Previous Target Therapy or Immunotherapy in Patients With Advanced Solid Tumors

NCT ID: NCT06322095

Last Updated: 2024-10-01

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE2
• Total Enrollment: 72 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-03-22
• Study Completion Date: 2025-12-31

Brief Summary

This study is aim to evaluate the preliminary efficacy of GH21 combined with previous target therapy or immunotherapy in patients with advanced solid tumors.

Detailed Description

This study preset two dose groups, dose group 1 is GH21 15 mg (BIW, D1D2) combined with ALK inhibitor, or MET inhibitor, or BRAF inhibitor +MEK inhibitor, or PD-1 inhibitor, or EGFR monoantibody, or other drugs such as FGFR inhibitor, and it is planned to enroll up to 36 subjects. Dose group 2 was GH21 6 mg (QD) combined with ALK inhibitor, or MET inhibitor, or BRAF inhibitor +MEK inhibitor, or PD-1 inhibitor, or EGFR monoclonal antibody, or other drugs such as FGFR inhibitor, and was planned to enroll up to 36 subjects.

Conditions

Patients With Advanced Solid Tumor; Advanced Solid Tumor With Oncogenic Driver Mutations

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

'GH21+PD-1'Group

GH21 combined with previous PD-1.

Group Type: EXPERIMENTAL

PD-1

Intervention Type: DRUG

Previous PD-1

GH21

Intervention Type: DRUG

Oral, 15mg BIW or 6mg QD

'GH21+ALK Inhibitor'Group

GH21 combined with previous ALK inhibitor.

Group Type: EXPERIMENTAL

ALK inhibitor

Intervention Type: DRUG

Previous ALK inhibitor

GH21

Intervention Type: DRUG

Oral, 15mg BIW or 6mg QD

'GH21+MET Inhibitor'Group

GH21 combined with previous MET inhibitor.

Group Type: EXPERIMENTAL

MET inhibitor

Intervention Type: DRUG

Previous MET inhibitor

GH21

Intervention Type: DRUG

Oral, 15mg BIW or 6mg QD

'GH21+BRAF Inhibitor+MEK Inhibitor'Group

GH21 combined with previous BRAF inhibitor and MEK inhibitor.

Group Type: EXPERIMENTAL

BRAF Inhibito

Intervention Type: DRUG

Previous BRAF inhibitor

GH21

Intervention Type: DRUG

Oral, 15mg BIW or 6mg QD

MEK Inhibitor

Intervention Type: DRUG

Previous MEK Inhibitor

'GH21+EGFR Monoclonal Antibody'Group

GH21 combined with previous EGFR Monoclonal Antibody.

Group Type: EXPERIMENTAL

EGFR Monoclonal antibody

Intervention Type: DRUG

Previous EGFR Monoclonal antibody

GH21

Intervention Type: DRUG

Oral, 15mg BIW or 6mg QD

Interventions

PD-1

Previous PD-1

Intervention Type: DRUG

MET inhibitor

Previous MET inhibitor

Intervention Type: DRUG

ALK inhibitor

Previous ALK inhibitor

Intervention Type: DRUG

BRAF Inhibito

Previous BRAF inhibitor

Intervention Type: DRUG

EGFR Monoclonal antibody

Previous EGFR Monoclonal antibody

Intervention Type: DRUG

GH21

Oral, 15mg BIW or 6mg QD

Intervention Type: DRUG

MEK Inhibitor

Previous MEK Inhibitor

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Subjects or their legal representatives can understand and voluntarily sign the written ICF (before the start of screening and any study procedures);

2. Male or female subjects aged ≥18 years;

3. Patients with advanced solid tumors confirmed by cytological or histological assessments;

4. Patients have at least one measurable lesion as defined by RECIST v1.1 (a tumor lesion in the area that has undergone radiotherapy or other loco-regional therapies, is generally not considered as measurable unless there is a disease progression in the lesion);

5. Life expectancy of ≥ 3 months;

6. ECOG PS score of 0-1;

7. The subjects must have adequate organ functions;

8. Male and female of reproductive potential must agree to take reliable contraceptive measures (hormone or barrier methods or abstinence) from signing the ICF until 6 months after the last dose. Pregnancy test results must be negative for female of reproductive potential within 7 days prior to the first dose of the investigational product.

Exclusion Criteria

1. Subjects who receive any chemotherapy or antitumor biologics within 3 weeks, or antitumor therapies such as radiotherapy and endocrine therapy within 4 weeks prior to the first dose of the investigational product, except for the following:

• Use of nitrosoureas or mitomycin C within 6 weeks prior to the first dose of the investigational product;
• Oral administration of fluorouracils, small molecule targeted drugs, and Chinese herbal medicines or Chinese patent medicines with antitumor indications within 5 half-lives or 2 weeks before the first dose of the investigational product (whichever is shorter);
• Small molecule TKI inhibitors within 5 half-lives or 2 weeks prior to the first dose of the investigational product (whichever is shorter);
• Local palliative radiotherapy within 2 weeks prior to the first dose of the investigational product; Note: If the latest anti-tumor therapy before enrollment is only the intended combination therapy, follow-up therapy can be carried out according to the original treatment cycle according to clinical needs, without waiting for elution.

2. Subjects who have had another investigational new drug or therapy within 4 weeks prior to the first dose of the investigational product;

3. Subjects who have had a major organ surgery (excluding needle biopsy) or significant trauma within 4 weeks prior to the first dose of the investigational product, or require an elective surgery during the study;

4. Subjects who have received strong P-gp inhibitors or inducers within 2 weeks or within 5 half-lives prior to the first dose of the investigational product;

5. Subjects with evidence of the following heart conditions:

• Acute myocardial infarction, unstable angina pectoris, coronary artery bypass grafting, cerebrovascular accident, or transient ischemic attack within 6 months prior to the first dose of the investigational product;
• Grade III-IV heart failure diagnosed according to the cardiac function classification of the New York Heart Association at screening;
• Echocardiography (ECHO) shows the left ventricular ejection fraction (LVEF) ≤ 50% at screening;
• QT interval corrected by Fridericia method (QTcF) is ≥ 450 ms (male) or ≥ 470 ms (female) at screening;
• Uncontrolled hypertension (systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg) despite of medication treatment at screening;

6. Subjects with dysphagia, gastrointestinal disorders that affect drug absorption, or other malabsorption conditions, such as intestinal obstruction, Crohn's disease, ulcerative colitis, short bowel syndrome, delayed gastric emptying, or severe gastrointestinal toxicities that have not resolved to Grade 2 or lower prior to the first dose of the investigational product; or subjects are diagnosed with a clinically significant or acute gastrointestinal disease;

7. Subjects with Uncontrolled pleural effusion, pericardial effusion, or pleural effusion requiring repeated drainage (once a month or more frequently);

8. Subjects with active central nervous system metastasis and/or carcinomatous meningitis (e.g., brain metastases accompanied by central nervous system symptoms, including headache, vomiting and dizziness, etc.);

9. Subjects with interstitial pneumonia, or any evidence of clinically active interstitial lung disease within 6 months before the first dose of the investigational product;

10. Sujects with arteriovenous thrombosis events, such as cerebrovascular accidents (including transient ischemic attacks), venous thrombosis, and pulmonary embolism, occurred within 6 months before the first dose of the investigational product;

11. Subjects with a history of other malignancies (excluding those deemed eligible by the investigator, such as skin squamous cell carcinoma in situ, basal cell carcinoma, and cervical cancer in situ that have been cured and have not relapsed for 5 years);

12. Subjects with a history of severe allergies, a history of allergies to the investigational drug/any excipient/combination drug, or to multiple drugs;

13. Subjects with hepatitis B virus infection (HBsAg positivity and DNA copies < 100 IU/mL); or hepatitis C virus infection (HCV antibody positivity, and HCV RNA > ULN); or human immunodeficiency virus infection (HIV antibody positivity); or infected with treponema pallidum (defined as TP-Ab positive);

14. Subjects with active infections requiring anti-infective treatment (Grade ≥ 2) or fever > 38°C of unknown etiology within 28 days prior to the first dose of the investigational product;

15. Subjects with autoimmune diseases in the active phase within 28 days prior to the first dose of the investigational product;

16. Subjects with any toxicity caused by a previous antitumor therapy that has not resolved to Grade ≤ 1 according to CTCAE 5.0 (except for alopecia, Grade 2 peripheral neuropathy, and/or other Grade ≤ 2 AEs of insignificant safety risks) before the first dose of the investigational product;

17. Female subjects who are pregnant or breastfeeding;

18. Subjects who are not suitable for this study due to any clinical or laboratory abnormalities or other reasons as assessed by the investigator.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Suzhou Genhouse Bio Co., Ltd.

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ning Li, Doctorate

Role: PRINCIPAL_INVESTIGATOR

+86-10-87788495

Haidan Wang, Doctorate

Role: STUDY_DIRECTOR

+86-512-86861608

Locations

Cancer Hospital Chinese Academy of Medical Science

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China

Site Status: NOT_YET_RECRUITING

Countries

China

Central Contacts

Yiming Zhou, Bachelor

Role: CONTACT

zhouyiming@genhousebio.com

+86-512-86861608

Facility Contacts

Ning Li, Doctorate

Role: primary

lining@cicams.ac.cn

（86）010-87788495

Yongsheng Wang, Doctorate

Role: primary

dolphin8012@yahoo.com

（86）025-83304616

Other Identifiers

GH21C202

Identifier Type: -

Identifier Source: org_study_id