The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease
NCT ID: NCT06304233
Last Updated: 2025-06-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
120 participants
OBSERVATIONAL
2023-12-13
2038-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Diagnosed with Schizophrenia
Patients with a ICD-10 diagnosis of Schizophrenia will undergo investigations to assess cardiac function, cardiovascular disease risk factors and DISC1 mRNA expression. Participants eligible for MRI will be invited to undergo cardiac MRI in addition to echocardiography.
Echocardiography
ultrasound assessment of heart structure, volume and function
Cardiac Magnetic Resonance Imaging
MRI assessment of heart structure, volume, function and tissue characteristics
Electrocardiography
Assessment of cardiac rhythm and electrical activity
Blood sampling
To measure DISC1 mRNA expression and other potential biomarkers
No mental health diagnosis
Participants without a mental health diagnosis will be randomly selected from an existing population registered in the HUNT data and biobank for whom, echocardiographic data and biological samples are available.Those enrolled as controls will be invited to participate in the cardiac MRI portion of the study.
Echocardiography
ultrasound assessment of heart structure, volume and function
Cardiac Magnetic Resonance Imaging
MRI assessment of heart structure, volume, function and tissue characteristics
Electrocardiography
Assessment of cardiac rhythm and electrical activity
Blood sampling
To measure DISC1 mRNA expression and other potential biomarkers
Interventions
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Echocardiography
ultrasound assessment of heart structure, volume and function
Cardiac Magnetic Resonance Imaging
MRI assessment of heart structure, volume, function and tissue characteristics
Electrocardiography
Assessment of cardiac rhythm and electrical activity
Blood sampling
To measure DISC1 mRNA expression and other potential biomarkers
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Both inpatient and outpatient
* Capable of giving informed consent
Exclusion Criteria
* Current or previous treatment with chemotherapy
* Current pregnancy
* Mothers less than 6 months post-partum
18 Years
65 Years
ALL
No
Sponsors
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St. Olavs Hospital
OTHER
Norwegian University of Science and Technology
OTHER
Responsible Party
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Principal Investigators
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Morten A Høydal, PhD
Role: STUDY_DIRECTOR
Norwegian University of Science and Technology
Locations
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Norwegian University of Science and Technology
Trondheim, , Norway
St Olavs Hospital, Trondheim University Hospital
Trondheim, , Norway
Countries
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Other Identifiers
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606103
Identifier Type: -
Identifier Source: org_study_id
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