To Assess With Ezefeno Tab. in Patients With Dyslipidemia and T2DM

NCT ID: NCT06293417

Last Updated: 2024-08-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

3958 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-01

Study Completion Date

2027-02-01

Brief Summary

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The goal of this Randomized controlled trials is to assess in the long term efficacy and safety of ezefeno. The primary endpoint are:

* major adverse cardiovascular events within 48 months of the trial duration
* microvascular events within 48 months of the trial duration

Detailed Description

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A prospective, randomized, open-label, parallel, multicenter, active-drug-controlled clinical trial to assess the long-term efficacy and safety of Combined Therapy with Ezefeno Tab. in patients with dyslipidemia who do not achieve adequate control of Non-HDL-C levels even with Moderate-intensity monotherapy.

Conditions

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T2DM (Type 2 Diabetes Mellitus) Dyslipidemias

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment group

Ezetimibe/fenofibrate (Ezefeno) and moderate-intensity statin

Group Type EXPERIMENTAL

Ezetimibe/fenofibrate (Ezefeno) and moderate-intensity statin

Intervention Type DRUG

Treatment group

Control group

Dose escalation of moderate-intensity statin

Group Type ACTIVE_COMPARATOR

Dose escalation of moderate-intensity statin

Intervention Type DRUG

Control group

Interventions

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Ezetimibe/fenofibrate (Ezefeno) and moderate-intensity statin

Treatment group

Intervention Type DRUG

Dose escalation of moderate-intensity statin

Control group

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with type 2 diabetes diagnosed by American Diabetes Association criteria
* Age ≥ 19 years
* Non-HDL-C ≥100 mg/dL, TG ≥200, \<500 mg/dL on moderate-intensity statins
* with cardiovascular risk factor

Exclusion Criteria

* Pregnant or breastfeeding women
* Uncontrolled hyperglycemia(more than 12.0% for Subject treated with anti-diabetic treatment.)
* Patient with myopathy and rhabdomyolysis
* AST/ALT more than 3 ULN
* Clinical evidence of genetic disorders such as galactose intolerance, Lapp lactose deficiency, and/or glucose-galactose malabsorption
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Korea University Anam Hospital

OTHER

Sponsor Role lead

Responsible Party

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Sin Gon Kim

professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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SIN-GON KIM

Role: PRINCIPAL_INVESTIGATOR

Korea University Anam Hospital

Locations

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Korea University Anam Hospital

Seoul, , South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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SIN-GON KIM

Role: CONTACT

8229205890

Facility Contacts

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Sin Gon Kim, MD

Role: primary

Other Identifiers

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HT-EF-01

Identifier Type: -

Identifier Source: org_study_id

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