Safety and Tolerability of Intravitreal Administration of VG901 in Patients With Retinitis Pigmentosa Due to Mutations in the CNGA1 Gene

NCT ID: NCT06291935

Last Updated: 2025-03-28

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: PHASE1
• Total Enrollment: 6 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-09-01
• Study Completion Date: 2026-04-30

Brief Summary

The goal of this phase 1 clinical trial is to learn about the safety and efficacy of a gene therapy, VG901, in patients with a rare disorder of the eye called Retinitis Pigmentosa. The main questions the study aims to answer are:

• What is the best tolerated dose and are there any side effects, in particular any inflammatory reactions post drug administration?
• Are there any early signs of efficacy on visual function?

Participants will be administered a single intravitreal dose of VG901 into the most affected eye through a syringe and followed up for a year to monitor safety and efficacy. There will be two cohorts of participants in this study. Study Cohort 1 will receive the low dose and Study Cohort 2 will receive the high dose as specified in the Protocol.

Conditions

Retinitis Pigmentosa

Study Design

• Allocation Method: NA
• Intervention Model: SEQUENTIAL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

VG901

Participants will receive a single dose of intravitreal injection of VG901 in most affected eye at Day 0.

Group Type: EXPERIMENTAL

VG901

Intervention Type: DRUG

Administered as specified in the treatment arm. Study Cohort 1 - Low dose; Study Cohort 2 - High dose

Other Names:

Gene Therapy (AAV2.NN-CNGA1)

Interventions

VG901

Administered as specified in the treatment arm. Study Cohort 1 - Low dose; Study Cohort 2 - High dose

Other Names:

Gene Therapy (AAV2.NN-CNGA1)

Intervention Type: DRUG

Other Intervention Names

AAV2.NN-CNGA1

Eligibility Criteria

Inclusion Criteria

To be eligible for study entry, subjects must satisfy all the following criteria:

1. Able to understand and willing to consent to study participation by a written informed consent

2. Male or female ≥ 18 years of age

3. Clinical diagnosis of RP

4. Confirmed pathogenic, biallelic variants in the CNGA1 gene

5. Ellipsoid zone (EZ) length of the fovea of ≥ 3000 μm in the study eye

Exclusion Criteria

Subjects will be excluded from the study if one or more of the following statements are applicable to either eye:

1. Additional interfering ocular conditions which would impact study results (e.g., ocular opacity and advanced cataract, uveitis, amblyopia)

2. History or presence of glaucoma

3. Ocular surgery, intravitreal or subretinal implantation of a medical device (within 6 months of screening)

4. Mutations known to cause inherited retinal disease other than biallelic variants in the CNGA1 gene

5. History of ocular infection with herpes simplex virus

6. History of ocular malignancies

7. History of disorders of the internal retina (e.g., retinal detachment)

8. Patients with uncontrolled diabetes (HbA1c > 7%)

9. Any other retinopathy due to other diseases - including, but not limited to arterial hypertension, previous vascular retinal occlusion, trauma or acquired inflammatory diseases, contraindication to pharmacological mydriasis (e.g., history of angle block glaucoma), diabetes (diabetic retinopathy including macular oedema)

10. Absence of visual function on the contralateral eye

11. Any damage to the optic nerve

12. Individuals performing any other therapy for RP within 3 months before the study, such as - but not limited to - transcorneal electrostimulation

13. Systemic conditions (e.g., autoimmune disorders) which may affect study participation or outcome measures

14. History of immunodeficiency or other medical conditions which may increase the risk of VG901 administration

15. Systemic illness (e.g., hepatitis or human immunodeficiency virus [HIV] infection) or medically relevant abnormal laboratory values (3 x upper limit of normal [ULN]) in blood analysis including renal and hepatic function

16. Current, or recent, participation in other study/ or administration of investigational biologic agent within 3 months of Screening; Use of any investigational agent, or systemic corticosteroids, or other immunosuppressive drug(s) within 3 months before Screening

17. History of allergy or sensitivity to any compound used in the study

18. Contraindications to systemic immunosuppression

19. Subjects with increased risk of bleeding (i.e., use of anticoagulants or anti-platelet agents within 7 days before VG901 administration and subjects with international normalized ratio > 2 or Quick < 50% or partial thromboplastin time > 50 seconds, thrombocytopenia, as well as any other known coagulopathy)

20. Subject/partner of childbearing potential unwilling to use adequate contraception for the period between Screening and 30 days after treatment, defined as the period from Screening until 30 days after treatment (defined as administration of therapeutic to the eye)

21. For females of childbearing potential, a positive pregnancy test at Screening or Baseline

22. Females who are breastfeeding

23. Previous receipt of any AAV gene therapy product

24. Any condition which leads the investigator to believe that subject cannot comply with the protocol requirements or that may place the subject at an unacceptable risk from participating

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

VeonGen Therapeutics GmbH

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Katarina Stingl

Role: PRINCIPAL_INVESTIGATOR

Center for Ophthalmology, University of Tuebingen

Locations

Center for Ophthalmology, University of Tuebingen

Tübingen, , Germany

Site Status: RECRUITING

Countries

Germany

Central Contacts

Andrea Rindtorff

Role: CONTACT

andrea.rindtorff@med.uni-tuebingen.de

+49 7071 29 87747

Facility Contacts

Andrea Rindtorff

Role: primary

andrea.rindtorff@med.uni-tuebingen.de

+49 7071 29 87747

Other Identifiers

EU CT: 2023-504383-42-00

Identifier Type: OTHER

Identifier Source: secondary_id

VG901-2021 A

Identifier Type: -

Identifier Source: org_study_id