RCT GBR One Stages Comparing A-Oss and Autogenous Bone Versus A-Oss and LCR-A

NCT ID: NCT06286605

Last Updated: 2024-02-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-01

Study Completion Date

2028-12-30

Brief Summary

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The aim of this randomized controlled trial is to evaluate the tridimensional bone stability after horizontal one-stage GBR using collagene membrane (OssMem) with a mix of Bovine Bone Substitute (A-Oss) and autogenous bone (test group) versus A-Oss and LCR-A, a synthetic bone (control group).

Detailed Description

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Conditions

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Guided Bone Regeneration Dental Implant

Keywords

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Dental Implant GBR

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Multicenter, randomized controlled trial of parallel-group design.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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A-oss and autogenous bone

In these group a GBR will be performed using only A-oss and autologous bone will be added and then will be covered with a membrane.

Group Type EXPERIMENTAL

A-oss and autogenous bone

Intervention Type PROCEDURE

Horizontal ridge augmentation in one stages approach will be performed using a mix of A-Oss and autologenous bone.

A-oss and LCR-A

In these subjects a GBR will be performed using only A-oss and LCR-A and then will be covered with a membrane.

Group Type ACTIVE_COMPARATOR

A-oss an LCR-A

Intervention Type PROCEDURE

Horizontal ridge augmentation in one stages approach will be performed using OssMem with A-Oss and LCR-A

Interventions

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A-oss and autogenous bone

Horizontal ridge augmentation in one stages approach will be performed using a mix of A-Oss and autologenous bone.

Intervention Type PROCEDURE

A-oss an LCR-A

Horizontal ridge augmentation in one stages approach will be performed using OssMem with A-Oss and LCR-A

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients that required an implant supported restoration and staged horizontal guided bone regeneration (defect of class IV according to Cawed and Howell) in both mandible or maxilla.
* Patents able to understand and sign an informed consent.
* Patients were to be 18 years or older with a residual horizontal ridge thickness of 4 mm or less (Cawood-Howell Class III- IV) in the intended implant site.
* Smokers will be categorized into: 1) non smokers; 2) moderate smokers (smoking up to 10 cigarettes/day); 3) heavy smokers (smoking more than 11 cigarettes/day). Only categories 1 and 2 will be included.

Exclusion Criteria

* General contraindications to implant surgery.
* Patients irradiated in the head and neck area.
* Immunosuppressed or immunocompromised patients.
* Patients treated or under treatment with intravenous amino-bisphosphonates.
* Patients with untreated periodontitis.
* Patients with poor oral hygiene and motivation.
* Uncontrolled diabetes.
* Pregnancy or nursing.
* Substance abuser.
* Heavy smokers (smoking more than 11 cigarettes/day).
* Psychiatric problems or unrealistic expectations.
* Lack of opposite occluding dentition in the area intended for implant placement.
* Immediate implants (extractive sites will have to be healed from 6-8 weeks).
* Patients participating in other studies, if the present protocol cannot be properly adhered to.
* Patients referred only for implant placement and cannot be followed ant the treating centre.
* Patients unable to be followed for 5 years
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Melodia, Dario, M.D.

INDIV

Sponsor Role collaborator

Pisano, Milena, M.D.

INDIV

Sponsor Role collaborator

Dr. Aurea Lumbau

UNKNOWN

Sponsor Role collaborator

Prof. Silvio Mario Meloni

UNKNOWN

Sponsor Role collaborator

Prof. Edoardo Baldoni

UNKNOWN

Sponsor Role collaborator

Università degli Studi di Sassari

OTHER

Sponsor Role lead

Responsible Party

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Marco Tallarico

Aisstent Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Marco Tallarico

Sassari, , Italy

Site Status

Countries

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Italy

Facility Contacts

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Dario Melodia, Dr

Role: primary

Marco Tallarico, Prof

Role: backup

Other Identifiers

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UNISS_PHD_Osstem_4

Identifier Type: -

Identifier Source: org_study_id