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Effects of Probiotic and HIIT in Obese Women

NCT ID: NCT06285578

Last Updated: 2024-02-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

47 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-01

Study Completion Date

2019-03-01

Brief Summary

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The aim of this study is to investigate whether there are the additive effects when implementing both high-intensity interval training (HIIT) and probiotics simultaneously on improving cardiorespiratory endurance and metabolism in middle-aged women.

Detailed Description

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High-intensity interval training (HIIT) is a time-efficiency exercise mode that has been shown to reduce body fat, fasting blood insulin levels, arterial stiffness, and aerobic capacity, helping to prevent and improve chronic diseases. Probiotics, on the other hand, have been found to have similar effects, including improving insulin sensitivity and endurance exercise performance, as well as reducing body fat. However, the additive effects of HIIT combined with probiotic supplements are unclear. In addition, on average, the life expectancy of women is longer than that of men. Middle-aged women are at high-risk for obesity and metabolic-related problems that threaten their long-term health. Therefore, whether the combination of HIIT and probiotics can be utilized to enhance the wellness of middle-aged women is the objective of this study.

Conditions

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Cardiorespiratory Fitness Metabolism Anthropometry

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Placebo control (C)

The subjects do not perform HIIT training, but consume one placebo packet every day on a fasting status for 8 weeks.

Group Type PLACEBO_COMPARATOR

Placebo supplementation

Intervention Type DIETARY_SUPPLEMENT

Yeast powder replaces probiotics in each packet. Each participant consume one packet every day on a fasting status for 8 weeks.

Probiotics supplementation (P)

Each participant consume one probiotic packet every day on a fasting status for 8 weeks.

Group Type EXPERIMENTAL

Probiotics supplementation

Intervention Type DIETARY_SUPPLEMENT

Probiotics, Lactiplantibacillus plantarum TWK10, are packaged in powder form. Each participant consume one packet every day on a fasting status for 8 weeks.

HIIT intervention (H)

HIIT training for 3 sessions per week and consume one placebo packet every day on a fasting status for 8 weeks.

Group Type EXPERIMENTAL

HIIT training

Intervention Type BEHAVIORAL

HIIT training is conduct at the intensity of 85-90% VO2max for 2 minutes with 1-minute inactive resting interval, repeating for 7 times. 3 sessions per week for 8 weeks.

Placebo supplementation

Intervention Type DIETARY_SUPPLEMENT

Yeast powder replaces probiotics in each packet. Each participant consume one packet every day on a fasting status for 8 weeks.

HIIT with probiotics intervention (HP)

Conduct HIIT training 3 sessions per week for 8 weeks and consume one probiotic packet every day on a fasting status for 8 weeks.

Group Type EXPERIMENTAL

Probiotics supplementation

Intervention Type DIETARY_SUPPLEMENT

Probiotics, Lactiplantibacillus plantarum TWK10, are packaged in powder form. Each participant consume one packet every day on a fasting status for 8 weeks.

HIIT training

Intervention Type BEHAVIORAL

HIIT training is conduct at the intensity of 85-90% VO2max for 2 minutes with 1-minute inactive resting interval, repeating for 7 times. 3 sessions per week for 8 weeks.

Interventions

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Probiotics supplementation

Probiotics, Lactiplantibacillus plantarum TWK10, are packaged in powder form. Each participant consume one packet every day on a fasting status for 8 weeks.

Intervention Type DIETARY_SUPPLEMENT

HIIT training

HIIT training is conduct at the intensity of 85-90% VO2max for 2 minutes with 1-minute inactive resting interval, repeating for 7 times. 3 sessions per week for 8 weeks.

Intervention Type BEHAVIORAL

Placebo supplementation

Yeast powder replaces probiotics in each packet. Each participant consume one packet every day on a fasting status for 8 weeks.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Female
* Age between 35-55 years old
* Total body fat percentage greater than 30%

Exclusion Criteria

* Male
* Participants who were taking probiotics supplementation or antibiotics
* Percentage of total body fat less than 30%
Minimum Eligible Age

35 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Taipei

OTHER

Sponsor Role lead

Responsible Party

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Chien-Wen Hou

Principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Chien-Wen Hou, Ph.D.

Role: STUDY_DIRECTOR

University of Taipei

Locations

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University of Taipei

Taipei, , Taiwan

Site Status

Countries

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Taiwan

References

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Chen YC, Wang HY, Ogita F, Hung CH, Kuo CH, Wang JP, Wang CM, Hou CW, Wang TY. Effects of probiotic supplementation with high-intensity interval training on cardiorespiratory endurance and metabolism in Middle-Aged Obese Women. J Int Soc Sports Nutr. 2024 Dec;21(1):2425609. doi: 10.1080/15502783.2024.2425609. Epub 2024 Dec 1.

Reference Type DERIVED
PMID: 39618097 (View on PubMed)

Other Identifiers

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MOST 107-2410-H-277-003

Identifier Type: -

Identifier Source: org_study_id