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Enhancing Prospective Thinking in Early Recovery (BEAM)

NCT ID: NCT06283472

Last Updated: 2025-12-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-17

Study Completion Date

2027-12-20

Brief Summary

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The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms. The main question\[s\] this trial aims to answer are:

* Will high-intensity EFT cues will produce greater delayed reward preference than low-intensity cues?
* Will high-intensity EFT cues effect greater treatment-seeking interest?
* Will high-intensity EFT cues elicit greater response in regions for prospective thinking during delay discounting (vs. low-intensity)
* Will nucleus accumbens-precuneus resting connectivity correlate with behavioral SS?
* Will the novel behavioral SS decision-making task activate the nucleus accumbens?

Researchers will compare the experimental (high-intensity group) and control (low-intensity) groups to see if there are differences in the results for the questions outlined above.

Detailed Description

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Conditions

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Alcohol Use Disorder

Keywords

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Alcohol Use Disorder Alcohol Abuse Heavy Drinking Alcohol

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Participants
Eligible participants will be randomly assigned to either the high-intensity (experimental) or low-intensity (control) groups.

Study Groups

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High-Intensity

Participants will receive high-intensity episodic future-thinking cue images, and high-intensity episodic recent-thinking cue images during an MRI decision-making task.

Group Type EXPERIMENTAL

High-Intensity Cue

Intervention Type BEHAVIORAL

Participants in the high-intensity group will receive high-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.

Low-Intensity (Control)

Participants will receive low-intensity episodic future-thinking cue images, and low-intensity episodic recent-thinking cue images during an MRI decision-making task.

Group Type ACTIVE_COMPARATOR

Low-Intensity Cue

Intervention Type BEHAVIORAL

Participants in the low-intensity group will receive low-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.

Interventions

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High-Intensity Cue

Participants in the high-intensity group will receive high-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.

Intervention Type BEHAVIORAL

Low-Intensity Cue

Participants in the low-intensity group will receive low-intensity image cues that represent self-reported events they did on the previous day and self-reported events they look forward to in the future.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Individuals who meet current heavy drinking (≥2 heavy drinking days/month OR ≥7 drinks/week for biological females, and ≥14 drinks/week if biological male \[NIAAA definition\] and/or AUDIT scores ≥8)
* English comprehension

Exclusion Criteria

* Unstable medical disorders
* Outside the age range of 18-60
* Smell/taste disorders
* Unstable psychiatric conditions
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Indiana University

OTHER

Sponsor Role lead

Responsible Party

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Brandon G. Oberlin, PhD

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Indiana University School of Medicine - Goodman Hall

Indianapolis, Indiana, United States

Site Status RECRUITING

Countries

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United States

Facility Contacts

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Sarah Turo, BA

Role: primary

Other Identifiers

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1805574553; Aims 14-16

Identifier Type: -

Identifier Source: org_study_id

2P60AA007611-403343

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2P60AA007611

Identifier Type: NIH

Identifier Source: secondary_id

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