Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)

NCT ID: NCT06274801

Last Updated: 2026-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

316 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-09-03

Study Completion Date

2026-12-31

Brief Summary

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This open-label extension study will evaluate the long-term safety, tolerability and efficacy of orally inhaled seralutinib in subjects who have completed a previous seralutinib study

Detailed Description

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The treatment period is planned to run until the market approval of seralutinib or until the study is terminated.

Conditions

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Pulmonary Arterial Hypertension

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Seralutinib 90 mg

Seralutinib inhaled orally twice per day (BID)

Group Type EXPERIMENTAL

Seralutinib

Intervention Type DRUG

Capsule containing seralutinib

Gereic Dry Powder Inhaler

Intervention Type DEVICE

Generic dry powder inhaler for seralutinib delivery

Interventions

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Seralutinib

Capsule containing seralutinib

Intervention Type DRUG

Gereic Dry Powder Inhaler

Generic dry powder inhaler for seralutinib delivery

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Subjects must have completed a qualifying last visit in a prior seralutinib PAH study on investigational product (IP) and in accordance with the protocol.
2. Evidence of an informed consent document, signed and dated by the subject, indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any subject-mandated procedures.
3. Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures
4. Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test at enrollment visit before first administration of Investigational Product (IP) in this study.
5. WOCBP who are not abstinent and intend to be sexually active with a non-sterilized male partner must be willing to use a highly effective method of contraception from consent through 30 days following the last administration of IP.
6. Male subjects: Non-sterilized male subjects who are not abstinent and intend to be sexually active with a female partner of childbearing potential must use a male condom from consent through 90 days after the last dose of IP.

Exclusion Criteria

1. Severe acute or chronic medical or laboratory abnormality that may increase the risk associated with study participation or seralutinib administration, unless associated with an ongoing AE and discussed with the Sponsor's medical monitor (MM) (or designee).
2. Have any other condition or reason that, in the opinion of the Investigator, would prohibit the subject from participating in the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GB002, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Richard Aranda, MD

Role: STUDY_DIRECTOR

Gossamer Bio Inc.

Locations

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Valley Advanced Lung Diseases Institute

Fresno, California, United States

Site Status

Department of Veterans Affairs Greater Los Angeles Healthcare System

Los Angeles, California, United States

Site Status

UC Davis Health Medical Center

Sacramento, California, United States

Site Status

Stanford Healthcare

Stanford, California, United States

Site Status

University of Florida Health

Gainesville, Florida, United States

Site Status

Mayo Clinic Jacksonville

Jacksonville, Florida, United States

Site Status

Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead

Atlanta, Georgia, United States

Site Status

The Emory Clinic

Atlanta, Georgia, United States

Site Status

Northside Hospital - Atlanta

Atlanta, Georgia, United States

Site Status

UI Health Hospital

Chicago, Illinois, United States

Site Status

University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Norton Pulmonary Specialists

Louisville, Kentucky, United States

Site Status

University of Michigan

Ann Arbor, Michigan, United States

Site Status

Washington University School of Medicine

St Louis, Missouri, United States

Site Status

University of Nebraska Medical Center

Omaha, Nebraska, United States

Site Status

University of New Mexico Health Sciences Center

Albuquerque, New Mexico, United States

Site Status

NYU Langone Health

New York, New York, United States

Site Status

University of Rochester Medical Center

Rochester, New York, United States

Site Status

UNC Hospitals

Chapel Hill, North Carolina, United States

Site Status

University of Cincinnati Medical Center

Cincinnati, Ohio, United States

Site Status

INTEGRIS Cardiovascular Physicians

Oklahoma City, Oklahoma, United States

Site Status

The Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Temple Heart and Vascular Institute (Outpatient Clinic)

Philadelphia, Pennsylvania, United States

Site Status

UPMC Presbyterian Hospital

Pittsburgh, Pennsylvania, United States

Site Status

Medical University of South Carolina - Nexus Research Center

Charleston, South Carolina, United States

Site Status

UT Southwestern Medical Center

Dallas, Texas, United States

Site Status

CHI St. Luke's Health Baylor College of Medicine Medical Center

Houston, Texas, United States

Site Status

Houston Methodist Outpatient Center

Houston, Texas, United States

Site Status

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Site Status

Intermountain Medical Center

Murray, Utah, United States

Site Status

University of Utah Hospital

Salt Lake City, Utah, United States

Site Status

Inova Fairfax Medical Campus

Falls Church, Virginia, United States

Site Status

Pulmonary Associates of Richmond, Inc.

Richmond, Virginia, United States

Site Status

Cardiologia Palermo

Buenos Aires, , Argentina

Site Status

Instituto de Cardiologia de Corrientes Juana Francisca Cabral

Corrientes, , Argentina

Site Status

Instuto de Investigacion Clinicas Quilmes

Quilmes, , Argentina

Site Status

Instituto Medico Rio Cuarto

Río Cuarto, , Argentina

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Hospital Provincial Dr. Jose Maria Cullen

Santa Fe, , Argentina

Site Status

Wesley Research Institute

Auchenflower, , Australia

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St Vincent's Hospital (Melbourne)

Fitzroy, , Australia

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Royal Hobart Hospital

Hobart, , Australia

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University Hospitals of Leuven (Campus Gasthuisberg)

Leuven, , Belgium

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Instituto das Pequenas Missionarias de Maria Imaculada - Hospital Madre Teresa

Belo Horizonte, , Brazil

Site Status

Complexo de Prevencao, Diagnostico, Terapia e Reabilitacao Respiratoria - Hospital Dia di Pulmao

Blumenau, , Brazil

Site Status

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, , Brazil

Site Status

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS

Porto Alegre, , Brazil

Site Status

Instituto do Coracao do Hospital das Clinicas da Faculdade de medicina da Universidade de Sao Paulo

São Paulo, , Brazil

Site Status

Nucleo de Gestao de Pesquisa/Hospital Sao Paulo - SPDM/UNIFESP

São Paulo, , Brazil

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Peter Lougheed Center

Calgary, , Canada

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London Health Sciences Centre - Victoria Hospital

London, , Canada

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University of Ottawa Heart Institute

Ottawa, , Canada

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University Health Network, Toronto General Hospital

Toronto, , Canada

Site Status

Centro de Investigacion Clinica UC-CICUC

Santiago, , Chile

Site Status

Enroll SpA

Santiago, , Chile

Site Status

Fundacion Abood Shaio

Bogotá, , Colombia

Site Status

Fundacion Neumologica Colombiana

Bogotá, , Colombia

Site Status

Institut klinicke a experimentalni mediciny Klinika kardiologie Ambulance plicni hypertenze

Prague, , Czechia

Site Status

Všeobecná fakultní nemocnice v Praze ll. interní klinika kardiologie a angiologie VFN a 1.LF UK Centrum pro plicní hvpertenzi

Prague, , Czechia

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Aarhus Universiteshospital

Aarhus, , Denmark

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CHU Bicetre, Service de Pneumologie et Reanimation Respiratorie

Le Kremlin-Bicêtre, , France

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Centre Hospitalier REgional Universitaire de Lille Hopital Cardiologique - Institut Coeur Poumon Service de Cardiologie

Lille, , France

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CHU de Nice - Hopital Pasteur

Nice, , France

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CHU de Poitiers

Poitiers, , France

Site Status

Zentrum fur Pulmonale Hypertonie, Klinik Ill fur lnnere Medizin (Kardiologie, Pneumologie, lnternistische lntensivmedizin), Herzzentrum der Universitat zu Koln

Cologne, , Germany

Site Status

Universitatsklinikum Giessen und Marburg GmbH Zentrum fur lnnere Medizin, Med. Klinik und Poliklinik II Studienambulanz fur Pulmonale Hypertonie

Giessen, , Germany

Site Status

Thoraxklinik Heidelberg gGmbH am Universitätsklinikum Heidelberg Zentrum für pulmonale Hypertonie

Heidelberg, , Germany

Site Status

Klinikum der LMU Medizinische Klinik und Poliklinik V

Munich, , Germany

Site Status

Krankenhaus Neuwittelsbach

München, , Germany

Site Status

Klinikum Würzburg Mitte gGmbH Medizinische Klinik mit Schwerpunkt Pneumologie und Beatmungsmedizin

Würzburg, , Germany

Site Status

"Evangelismos" General Hospital of Athens, 1st Department of Clinical Care and Pulmonary Hypertension Clinic

Athens, , Greece

Site Status

ATTIKON University Hospital, 2nd Critical Care Department

Athens, , Greece

Site Status

Onassis Cardiac Surgery Center, Non-Invasive Cardiology Department

Kallithea, , Greece

Site Status

AHEPA University General Hospital of Thessaloniki, 1st Cardiology Clinic

Thessaloniki, , Greece

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Mater Misericordiae University Hospital

Dublin, , Ireland

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Lady Davis Carmel Medical Center

Haifa, , Israel

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IRCCS Azienda Ospedaliero Universitaria Di Bologna - Policlinico S. Orsola-Malpighi - UOC Cardiologia

Bologna, , Italy

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Azienda Ospedaliera Dei Colli - Ospedale Monaldi

Napoli, , Italy

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Fondazione IRCCS Policlinico San Matteo

Pavia, , Italy

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A.O.U. Policlinico Umberto I

Roma, , Italy

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University of Tokyo Hospital

Bunkyō City, , Japan

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Kyushu University Hospital

Fukuoka, , Japan

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Kyorin University Hospital

Mitaka, , Japan

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Nagoya University Hospital

Nagoya, , Japan

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NHO Okayama Medical Center

Okayama, , Japan

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Keio University Hospital

Shinjuku-Ku, , Japan

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National Cerebral and Cardiovascular Center

Suita, , Japan

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Pauls Stradins Clinical University Hospital

Riga, , Latvia

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Hospital of Lithuanian University of Health Sciences Kauno klinikos

Kaunas, , Lithuania

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Instituto Nacional de Cardiologia Ignacio Chavez

Mexico City, , Mexico

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Unidad de Investigacion Clinica en Medicina, S.C.

Monterrey, , Mexico

Site Status

Amsterdam UMC, location VU mc

Amsterdam, , Netherlands

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Krakowski Szpital Specjalistyczny Im. Sw. Jana Pawla II, Oddzial Kliniczny Chorob Serca i Naczyn z Pododdzialem Intensywnego Nadzoru Kardiologicznego

Krakow, , Poland

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Europejskie Centrum Zdrowia Otwock Sp.zo.o. Szpital im. Fryderyka Chopina Oddzial Kardiologiczny

Otwock, , Poland

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Unidade Local de Saude de Santa Maria, E.P.E. Hospital Pulido Valente

Lisbon, , Portugal

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Unidade Local de Saude de Santo Antonio, E.P.E. Hospital de Santo Antonio

Porto, , Portugal

Site Status

Institutul De Urgenta Pentru Boli Cardiovasculare Prof. Dr. C. C. Iliescu Cardiology 2

Bucharest, , Romania

Site Status

"Niculae Stancioiu" Emergency Heart Institute for Cardiovascular Diseases, Cardiology 1 Department

Cluj-Napoca, , Romania

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King Fahad Medical City

Riyadh, , Saudi Arabia

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King Faisal Specialist Hospital and Research Center

Riyadh, , Saudi Arabia

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University Clinical Centre of Serbia, Cardiology Clinic

Belgrade, , Serbia

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National Heart Centre Singapore

Singapore, , Singapore

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Asan Medical Center

Seoul, , South Korea

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Samsung Medical Center

Seoul, , South Korea

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Seoul National University Hospital

Seoul, , South Korea

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Hospital Clinic I Provincial

Barcelona, , Spain

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Hospital Universitario 12 De Octubre

Madrid, , Spain

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Hospital Universitario Marques de Valdecilla

Santander, , Spain

Site Status

Hospital Universitario Virgen del Rocio

Seville, , Spain

Site Status

Hospital Universitario de Toledo

Toledo, , Spain

Site Status

Royal Papworth Hospital NHS Foundation Trust

Cambridge, , United Kingdom

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Golden Jubilee National Hospital

Clydebank, , United Kingdom

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Hammersmith Hospital

London, , United Kingdom

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Royal Free Hospital, Clinical Research Facility

London, , United Kingdom

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Freeman Hospital

Newcastle, , United Kingdom

Site Status

Royal Hallamshire Hospital

Sheffield, , United Kingdom

Site Status

Countries

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United States Argentina Australia Belgium Brazil Canada Chile Colombia Czechia Denmark France Germany Greece Ireland Israel Italy Japan Latvia Lithuania Mexico Netherlands Poland Portugal Romania Saudi Arabia Serbia Singapore South Korea Spain United Kingdom

Other Identifiers

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2023-506334-75

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

GB002-3102

Identifier Type: -

Identifier Source: org_study_id

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