Antiplatelet Therapy in Chronic Urticaria

NCT ID: NCT06268470

Last Updated: 2024-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-01

Study Completion Date

2024-05-01

Brief Summary

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This study compares the combination of antiplatelets and antihistamine versus antihistamine alone for the treatment of chronic spontaneous urticaria

Detailed Description

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This study is a randomized control trial comparing the effectiveness of the combination of antiplatelets and antihistamine and antihistamine alone for the treatment of chronic spontaneous urticaria

Conditions

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Chronic Urticaria

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Patients diagnosed with chronic urticaria will be assigned to 2 treatment arms. 1. high dose antihistamine with antiplatelets; and 2. high dose antihistamine alone.
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators
Identical capsules

Study Groups

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Desloratadine

Oral desloratadine 20 mg/day (antihistamine) for 4 weeks

Group Type ACTIVE_COMPARATOR

Desloratadine

Intervention Type DRUG

Desloratadine 20 mg/day

Desloratadine plus cilostazol and dipyridamole

Oral desloratadine 20 mg/day (antihistamine) in conjunction with cilostazol 150 mg/day and dipyridamole 50 mg/day (antiplatelets) for 4 weeks

Group Type EXPERIMENTAL

Desloratadine plus cilostazol and dipyridamole

Intervention Type DRUG

Desloratadine 20 mg/day plus cilostazol 150 mg/day and dipyridamole 50 mg/day

Desloratadine

Intervention Type DRUG

Desloratadine 20 mg/day

Interventions

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Desloratadine plus cilostazol and dipyridamole

Desloratadine 20 mg/day plus cilostazol 150 mg/day and dipyridamole 50 mg/day

Intervention Type DRUG

Desloratadine

Desloratadine 20 mg/day

Intervention Type DRUG

Other Intervention Names

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Antihistamine plus antiplatelets Antihistamine alone

Eligibility Criteria

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Inclusion Criteria

Chronic spontaneous urticaria

D-dimer levels over 500 ng/ml

Not respond to a conventional dose of antihistamine

Exclusion Criteria

Are taking aspirin

Have bleeding tendency

Have concurrent severe medical illnesses

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chulalongkorn University

OTHER

Sponsor Role lead

Responsible Party

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Assoc. Prof. Jettanong Klaewsongkram, MD.

Assoc. Prof. Jettanong Klaewsongkram, MD.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jettanong Klaewsongkram, MD

Role: PRINCIPAL_INVESTIGATOR

Chulalongkorn University

Locations

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Faculty of Medicine, Chulalongkorn University

Bangkok, , Thailand

Site Status

Countries

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Thailand

Other Identifiers

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Chula-ARC 001/18

Identifier Type: -

Identifier Source: org_study_id

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