Clinical Deterioration in Cerebral Venous Thrombosis: A Predictive Study

NCT ID: NCT06266585

Last Updated: 2024-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

273 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-01-01

Study Completion Date

2024-01-01

Brief Summary

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The objective of this retrospective, prospective, multicenter cohort study is to determine the risk factors for deterioration of CVT patients after admission and establish a scoring model for risk stratification of patients. This study included two stages, the first stage was to enroll CVT patients from a single center from 2017 to 2022 for modeling, and the second stage was to enroll CVT patients from three centers in 2023 for external validation

Detailed Description

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Conditions

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Cerebral Venous Thrombosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Age≄ 18 years old
* Patients were diagnosed with cerebral venous thrombosis (CVT) through imaging techniques such as Computed Tomography Venography (CTV), Magnetic Resonance Venography (MRV), or Digital Subtraction Angiography (DSA)
* The diagnostic algorithm for CVT conformed to the current guideline criteria

Exclusion Criteria

* Patients who had performed endovascular treatment (EVT) or decompressive craniectomy (DC) before admission and those whose primary treatment was EVT or DC rather than conservative treatment after admission
* Patients with severe hepatic or renal insufficiency
* Patients with intracranial tumors
* Patients with other cerebrovascular diseases
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Beijing Chao Yang Hospital

OTHER

Sponsor Role collaborator

Beijing Friendship Hospital

OTHER

Sponsor Role collaborator

Beijing Tiantan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wang Shuo

Director of Department of cerebrovascular Neurosurgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Capital Medical University Affiliated Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

Site Status

Countries

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China

References

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Feng Y, Mo S, Li X, Jiang P, Wu J, Li J, Liu P, Wang S, Liu Q, Tong X. Development and validation of a score for clinical deterioration in patients with cerebral venous thrombosis. Neurosurg Rev. 2025 Jan 16;48(1):56. doi: 10.1007/s10143-025-03224-7.

Reference Type DERIVED
PMID: 39815140 (View on PubMed)

Other Identifiers

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HX-B-2023090

Identifier Type: -

Identifier Source: org_study_id

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